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Article: A model of cell motility leading to biphasic dependence of transport speed on adhesive strength

TitleA model of cell motility leading to biphasic dependence of transport speed on adhesive strength
Authors
KeywordsAdhesion and adhesives
Cell motility
Chemo-mechanical processes
Issue Date2010
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jmps
Citation
Journal Of The Mechanics And Physics Of Solids, 2010, v. 58 n. 4, p. 502-514 How to Cite?
AbstractA rolling model for cell motility is proposed here where the movement of cell is treated as a result of the continuous release and growth of adhesions at the trailing and leading edge of the cell, respectively. The appearance of actin polymerization is key in this model as it breaks the symmetry of adhesion characteristics. The cell speed predicted here is in the correct range and exhibits a biphasic relationship with the cell-substrate adhesive strength which is consistent with experimental observations. We will show that this biphasic dependence of cell speed on adhesivity is due to the interplay between the energy dissipation associated with cell movement and the thermal fluctuations of actin filaments necessary for polymerization. Our results also suggest that the mobility of adhesion molecules is not only unnecessary but may actually limit cell motility. © 2010 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/129267
ISSN
2015 Impact Factor: 3.875
2015 SCImago Journal Rankings: 2.529
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200809159003
Funding Information:

This investigation was supported by the Seed Funding Programme for Basic Research from The University of Hong Kong (Project No. 200809159003).

References

 

DC FieldValueLanguage
dc.contributor.authorLin, Yen_HK
dc.date.accessioned2010-12-23T08:34:25Z-
dc.date.available2010-12-23T08:34:25Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of The Mechanics And Physics Of Solids, 2010, v. 58 n. 4, p. 502-514en_HK
dc.identifier.issn0022-5096en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129267-
dc.description.abstractA rolling model for cell motility is proposed here where the movement of cell is treated as a result of the continuous release and growth of adhesions at the trailing and leading edge of the cell, respectively. The appearance of actin polymerization is key in this model as it breaks the symmetry of adhesion characteristics. The cell speed predicted here is in the correct range and exhibits a biphasic relationship with the cell-substrate adhesive strength which is consistent with experimental observations. We will show that this biphasic dependence of cell speed on adhesivity is due to the interplay between the energy dissipation associated with cell movement and the thermal fluctuations of actin filaments necessary for polymerization. Our results also suggest that the mobility of adhesion molecules is not only unnecessary but may actually limit cell motility. © 2010 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jmpsen_HK
dc.relation.ispartofJournal of the Mechanics and Physics of Solidsen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Journal of the Mechanics and Physics of Solids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of the Mechanics and Physics of Solids, 2010, v. 58 n. 4, p. 502-514. DOI: 10.1016/j.jmps.2010.01.010-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAdhesion and adhesivesen_HK
dc.subjectCell motilityen_HK
dc.subjectChemo-mechanical processesen_HK
dc.titleA model of cell motility leading to biphasic dependence of transport speed on adhesive strengthen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-5096&volume=58&issue=4&spage=502&epage=514&date=2010&atitle=A+model+of+cell+motility+leading+to+biphasic+dependence+of+transport+speed+on+adhesive+strength-
dc.identifier.emailLin, Y:ylin@hku.hken_HK
dc.identifier.authorityLin, Y=rp00080en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.jmps.2010.01.010en_HK
dc.identifier.scopuseid_2-s2.0-77349120010en_HK
dc.identifier.hkuros178055en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77349120010&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume58en_HK
dc.identifier.issue4en_HK
dc.identifier.spage502en_HK
dc.identifier.epage514en_HK
dc.identifier.eissn1873-4782-
dc.identifier.isiWOS:000276171400004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLin, Y=7406585339en_HK
dc.identifier.citeulike6864561-

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