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Article: Controlled release of dexamethasone from porous PLGA scaffolds under cyclic loading

TitleControlled release of dexamethasone from porous PLGA scaffolds under cyclic loading
Authors
KeywordsCyclic loading
Dexamethasone
Microsphere
PLGA
Scaffold
Issue Date2010
PublisherScience China Press, co-published with Springer. The Journal's web site is located at http://chem.scichina.com:8081/sciBe/EN/volumn/current.shtml
Citation
Science China Chemistry, 2010, v. 53 n. 3, p. 594-598 How to Cite?
AbstractPoly(L-lactide)-b-poly(ethylene glycol) (PLLA-PEG) microspheres containing dexamethasone (Dex) have been fabricated using a spray-drying technique. Porous poly(lactic-co-glycolic acid) (PLGA) scaffolds were prepared using a method combining thermally induced phase separation and porogen leaching. A post-seeding technique was used to immobilize Dex-containing PLLA-PEG microspheres on porous PLGA scaffolds, and drug-containing microspheres- scaffolds (MS-S) were obtained. Simple Dex-containing scaffolds (D-S) were also made as the control by directly dissolving Dex in the PLGA solution during scaffold fabrication. The morphologies of microspheres and scaffolds were studied by scanning electron microscopy. Drug release profiles of both MS-S and D-S were determined under cyclic loading and shaking water bath, respectively. The cumulative release of Dex was measured using an ultraviolet visible spectrophotometer. The results show that the incorporation of Dex and microspheres had little effect on the overall morphology of the porous PLGA scaffolds. Cyclic loading significantly accelerated the release of Dex from the drug-containing scaffolds. Compared with D-S, MS-S reduced the drug release rate. The controlled drug delivery of tissue engineering scaffolds under cyclic loading is a key factor to mimic the in vivo mechanical environments and achieve optical clinical efficacy. © Science China Press and Springer-Verlag Berlin Heidelberg 2010.
Persistent Identifierhttp://hdl.handle.net/10722/129264
ISSN
2015 Impact Factor: 2.429
2015 SCImago Journal Rankings: 0.567
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China10672015
30828008
Funding Information:

The authors express their great thanks for the support from the National Natural Science Foundation of China (Grant Nos. 10672015 & 30828008)

References

 

DC FieldValueLanguage
dc.contributor.authorTang, GWen_HK
dc.contributor.authorYang, YFen_HK
dc.contributor.authorSun, APen_HK
dc.contributor.authorSong, TTen_HK
dc.contributor.authorZhao, YHen_HK
dc.contributor.authorYuan, XBen_HK
dc.contributor.authorYuan, XYen_HK
dc.contributor.authorFan, YBen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2010-12-23T08:34:24Z-
dc.date.available2010-12-23T08:34:24Z-
dc.date.issued2010en_HK
dc.identifier.citationScience China Chemistry, 2010, v. 53 n. 3, p. 594-598en_HK
dc.identifier.issn1674-7291en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129264-
dc.description.abstractPoly(L-lactide)-b-poly(ethylene glycol) (PLLA-PEG) microspheres containing dexamethasone (Dex) have been fabricated using a spray-drying technique. Porous poly(lactic-co-glycolic acid) (PLGA) scaffolds were prepared using a method combining thermally induced phase separation and porogen leaching. A post-seeding technique was used to immobilize Dex-containing PLLA-PEG microspheres on porous PLGA scaffolds, and drug-containing microspheres- scaffolds (MS-S) were obtained. Simple Dex-containing scaffolds (D-S) were also made as the control by directly dissolving Dex in the PLGA solution during scaffold fabrication. The morphologies of microspheres and scaffolds were studied by scanning electron microscopy. Drug release profiles of both MS-S and D-S were determined under cyclic loading and shaking water bath, respectively. The cumulative release of Dex was measured using an ultraviolet visible spectrophotometer. The results show that the incorporation of Dex and microspheres had little effect on the overall morphology of the porous PLGA scaffolds. Cyclic loading significantly accelerated the release of Dex from the drug-containing scaffolds. Compared with D-S, MS-S reduced the drug release rate. The controlled drug delivery of tissue engineering scaffolds under cyclic loading is a key factor to mimic the in vivo mechanical environments and achieve optical clinical efficacy. © Science China Press and Springer-Verlag Berlin Heidelberg 2010.en_HK
dc.languageengen_US
dc.publisherScience China Press, co-published with Springer. The Journal's web site is located at http://chem.scichina.com:8081/sciBe/EN/volumn/current.shtmlen_HK
dc.relation.ispartofScience China Chemistryen_HK
dc.subjectCyclic loadingen_HK
dc.subjectDexamethasoneen_HK
dc.subjectMicrosphereen_HK
dc.subjectPLGAen_HK
dc.subjectScaffolden_HK
dc.titleControlled release of dexamethasone from porous PLGA scaffolds under cyclic loadingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1674-7291&volume=53&issue=3&spage=594&epage=598&date=2010&atitle=Controlled+release+of+dexamethasone+from+porous+PLGA+scaffolds+under+cyclic+loading-
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11426-010-0074-3en_HK
dc.identifier.scopuseid_2-s2.0-77950927552en_HK
dc.identifier.hkuros177523en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950927552&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume53en_HK
dc.identifier.issue3en_HK
dc.identifier.spage594en_HK
dc.identifier.epage598en_HK
dc.identifier.isiWOS:000276582800021-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridTang, GW=23494188700en_HK
dc.identifier.scopusauthoridYang, YF=7409383687en_HK
dc.identifier.scopusauthoridSun, AP=35335440500en_HK
dc.identifier.scopusauthoridSong, TT=35335218100en_HK
dc.identifier.scopusauthoridZhao, YH=7406633316en_HK
dc.identifier.scopusauthoridYuan, XB=7402202601en_HK
dc.identifier.scopusauthoridYuan, XY=7402202655en_HK
dc.identifier.scopusauthoridFan, YB=23134679300en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK

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