File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A free-breathing non-contrast-enhanced pulmonary magnetic resonance angiography at 3 Tesla

TitleA free-breathing non-contrast-enhanced pulmonary magnetic resonance angiography at 3 Tesla
Authors
Issue Date2009
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2009, v. 122 n. 18, p. 2111-2116 How to Cite?
AbstractBackground: The breathhold contrast-enhanced three-dimensional magnetic resonance angiography (MRA) using T1-weighted gradient-echo imaging sequence is the standard technique for MRA of the thorax. However, this technique is not desirable for certain patients with respiratory insufficiency, serious renal impairment, or allergy to contrast agents. The objective of this study was to optimize and evaluate a non-contrast-enhanced free-breathing pulmonary MRA protocol at 3 Tesla. Methods: The time-of-flight protocol was based on a two-dimensional T1-weighted turbo field echo sequence with slice-selective inversion recovery and magnetization transfer preparation together with respiratory navigator gating, cardiac gating, and parallel imaging. Optimal values for time of inversion delay, flip angle and slice thickness were experimentally determined and used for all subjects. Results: Excellent pulmonary MRA images, in which the 7th order branches of pulmonary arteries could be reliably identified, were obtained in the 12 free-breathing healthy volunteers. TI of ∼300 ms provides the best suppression of background thoracic and cardiac muscles and effective inflow enhancement. With increasing flip angle, the pulmonary vessels gradually brightened and exhibited optimal contrast at 20°-30°. The 2 mm slice thickness and 0.5 mm slice overlap is suitable for visualization of the peripheral pulmonary vessel. Conclusions: The MRA protocol at 3 Tesla may have clinical significance for pulmonary vascular imaging in patients who are not available for contrast-enhanced 3D MRA and CT angiography examination or are unable to sustain a long breath-hold.
Persistent Identifierhttp://hdl.handle.net/10722/129235
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China30200066
Programs Foundation of the Ministry of Education of China2004069805
Hong Kong Research Grant CouncilGRF7794/07M
Funding Information:

This work was supported in part by grants from the National Natural Science Foundation of China (No.30200066), Ph.D. Programs Foundation of the Ministry of Education of China (No. 2004069805) and Hong Kong Research Grant Council (No. GRF7794/07M).

References

 

DC FieldValueLanguage
dc.contributor.authorYang, Jen_HK
dc.contributor.authorWang, Wen_HK
dc.contributor.authorWang, YRen_HK
dc.contributor.authorNiu, Gen_HK
dc.contributor.authorJin, CWen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-12-23T08:33:48Z-
dc.date.available2010-12-23T08:33:48Z-
dc.date.issued2009en_HK
dc.identifier.citationChinese Medical Journal, 2009, v. 122 n. 18, p. 2111-2116en_HK
dc.identifier.issn0366-6999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129235-
dc.description.abstractBackground: The breathhold contrast-enhanced three-dimensional magnetic resonance angiography (MRA) using T1-weighted gradient-echo imaging sequence is the standard technique for MRA of the thorax. However, this technique is not desirable for certain patients with respiratory insufficiency, serious renal impairment, or allergy to contrast agents. The objective of this study was to optimize and evaluate a non-contrast-enhanced free-breathing pulmonary MRA protocol at 3 Tesla. Methods: The time-of-flight protocol was based on a two-dimensional T1-weighted turbo field echo sequence with slice-selective inversion recovery and magnetization transfer preparation together with respiratory navigator gating, cardiac gating, and parallel imaging. Optimal values for time of inversion delay, flip angle and slice thickness were experimentally determined and used for all subjects. Results: Excellent pulmonary MRA images, in which the 7th order branches of pulmonary arteries could be reliably identified, were obtained in the 12 free-breathing healthy volunteers. TI of ∼300 ms provides the best suppression of background thoracic and cardiac muscles and effective inflow enhancement. With increasing flip angle, the pulmonary vessels gradually brightened and exhibited optimal contrast at 20°-30°. The 2 mm slice thickness and 0.5 mm slice overlap is suitable for visualization of the peripheral pulmonary vessel. Conclusions: The MRA protocol at 3 Tesla may have clinical significance for pulmonary vascular imaging in patients who are not available for contrast-enhanced 3D MRA and CT angiography examination or are unable to sustain a long breath-hold.en_HK
dc.languageengen_US
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_HK
dc.relation.ispartofChinese Medical Journalen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshContrast Mediaen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMagnetic Resonance Angiography - methodsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPulmonary Artery - anatomy & histologyen_HK
dc.subject.meshPulmonary Circulation - physiologyen_HK
dc.subject.meshPulmonary Veins - anatomy & histologyen_HK
dc.subject.meshYoung Adulten_HK
dc.titleA free-breathing non-contrast-enhanced pulmonary magnetic resonance angiography at 3 Teslaen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.3760/cma.j.issn.0366-6999.2009.18.007en_HK
dc.identifier.pmid19781294-
dc.identifier.scopuseid_2-s2.0-70350602355en_HK
dc.identifier.hkuros177129en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350602355&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume122en_HK
dc.identifier.issue18en_HK
dc.identifier.spage2111en_HK
dc.identifier.epage2116en_HK
dc.identifier.isiWOS:000270344800007-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridYang, J=23391308100en_HK
dc.identifier.scopusauthoridWang, W=8712528900en_HK
dc.identifier.scopusauthoridWang, YR=35489368600en_HK
dc.identifier.scopusauthoridNiu, G=35273273000en_HK
dc.identifier.scopusauthoridJin, CW=35200640500en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats