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Article: Separate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage iron

TitleSeparate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage iron
Authors
KeywordsFerritin
Hemosiderin
Iron overload
Liver
MRI
Quantification
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2010, v. 63 n. 5, p. 1201-1209 How to Cite?
AbstractA new MRI method is proposed for separately quantifying the two principal forms of tissue storage (nonheme) iron: ferritin iron, a dispersed, soluble fraction that can be rapidly mobilized, and hemosiderin iron, an aggregated, insoluble fraction that serves as a long-term reserve. The method utilizes multiple spin echo sequences, exploiting the fact that aggregated iron can induce nonmonoexponential signal decay for multiple spin echo sequences. The method is validated in vitro for agarose phantoms, simulating dispersed iron with manganese chloride, and aggregated iron with iron oxide microspheres. To demonstrate feasibility for human studies, preliminary in vivo data from two healthy controls and six patients with transfusional iron overload are presented. For both phantoms and human subjects, conventional R 2 and R 2*relaxation rates are also measured in order to contrast the proposed method with established MRI iron quantification techniques. Quantification of dispersed (ferritin-like) iron may provide a new means of monitoring the risk of iron-induced toxicity in patients with iron overload and, together with quantification of aggregated (hemosiderin-like) iron, improve the accuracy of estimates for total storage iron. © 2010 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/129234
ISSN
2015 Impact Factor: 3.782
2015 SCImago Journal Rankings: 2.197
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of HealthR01-DK069373
R01-DK066251
R01-DK049108
American Heart Association0730143N
Hong Kong Research Grant CouncilGRF HKU 7794/07M
Funding Information:

National Institutes of Health; Grant numbers: R01-DK069373, R01-DK066251, R01-DK049108; Grant sponsor: American Heart Association; Grant number: 0730143N; Grant sponsor: Hong Kong Research Grant Council; Grant number: GRF HKU 7794/07M.

References

 

DC FieldValueLanguage
dc.contributor.authorJensen, JHen_HK
dc.contributor.authorTang, Hen_HK
dc.contributor.authorTosti, CLen_HK
dc.contributor.authorSwaminathan, SVen_HK
dc.contributor.authorNunez, Aen_HK
dc.contributor.authorHultman, Ken_HK
dc.contributor.authorSzulc, KUen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorKim, Den_HK
dc.contributor.authorSheth, Sen_HK
dc.contributor.authorBrown, TRen_HK
dc.contributor.authorBrittenham, GMen_HK
dc.date.accessioned2010-12-23T08:33:48Z-
dc.date.available2010-12-23T08:33:48Z-
dc.date.issued2010en_HK
dc.identifier.citationMagnetic Resonance In Medicine, 2010, v. 63 n. 5, p. 1201-1209en_HK
dc.identifier.issn0740-3194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129234-
dc.description.abstractA new MRI method is proposed for separately quantifying the two principal forms of tissue storage (nonheme) iron: ferritin iron, a dispersed, soluble fraction that can be rapidly mobilized, and hemosiderin iron, an aggregated, insoluble fraction that serves as a long-term reserve. The method utilizes multiple spin echo sequences, exploiting the fact that aggregated iron can induce nonmonoexponential signal decay for multiple spin echo sequences. The method is validated in vitro for agarose phantoms, simulating dispersed iron with manganese chloride, and aggregated iron with iron oxide microspheres. To demonstrate feasibility for human studies, preliminary in vivo data from two healthy controls and six patients with transfusional iron overload are presented. For both phantoms and human subjects, conventional R 2 and R 2*relaxation rates are also measured in order to contrast the proposed method with established MRI iron quantification techniques. Quantification of dispersed (ferritin-like) iron may provide a new means of monitoring the risk of iron-induced toxicity in patients with iron overload and, together with quantification of aggregated (hemosiderin-like) iron, improve the accuracy of estimates for total storage iron. © 2010 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_HK
dc.relation.ispartofMagnetic Resonance in Medicineen_HK
dc.rightsMagnetic Resonance in Medicine. Copyright © John Wiley & Sons, Inc.-
dc.subjectFerritinen_HK
dc.subjectHemosiderinen_HK
dc.subjectIron overloaden_HK
dc.subjectLiveren_HK
dc.subjectMRIen_HK
dc.subjectQuantificationen_HK
dc.subject.meshFerritins - metabolism-
dc.subject.meshHemosiderin - metabolism-
dc.subject.meshImage Interpretation, Computer-Assisted - methods-
dc.subject.meshLiver - anatomy and histology - metabolism-
dc.subject.meshMagnetic Resonance Imaging - methods-
dc.titleSeparate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage ironen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0740-3194&volume=63&issue=5&spage=1201&epage=1209&date=2010&atitle=Separate+MRI+quantification+of+dispersed+(ferritin-like)+and+aggregated+(hemosiderin-like)+storage+iron-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/mrm.22273en_HK
dc.identifier.pmid20432291-
dc.identifier.pmcidPMC2943155-
dc.identifier.scopuseid_2-s2.0-77955290109en_HK
dc.identifier.hkuros177194en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955290109&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue5en_HK
dc.identifier.spage1201en_HK
dc.identifier.epage1209en_HK
dc.identifier.isiWOS:000277098100008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJensen, JH=7404521984en_HK
dc.identifier.scopusauthoridTang, H=36827331000en_HK
dc.identifier.scopusauthoridTosti, CL=10641524200en_HK
dc.identifier.scopusauthoridSwaminathan, SV=8911039200en_HK
dc.identifier.scopusauthoridNunez, A=36438665500en_HK
dc.identifier.scopusauthoridHultman, K=23988981100en_HK
dc.identifier.scopusauthoridSzulc, KU=8384322700en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridKim, D=8524290700en_HK
dc.identifier.scopusauthoridSheth, S=7102603512en_HK
dc.identifier.scopusauthoridBrown, TR=7404319370en_HK
dc.identifier.scopusauthoridBrittenham, GM=7005583587en_HK
dc.identifier.citeulike9237305-

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