File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: In vivo DTI assessment of hepatic ischemia reperfusion injury in an experimental rat model

TitleIn vivo DTI assessment of hepatic ischemia reperfusion injury in an experimental rat model
Authors
KeywordsDiffusion tensor imaging
Diffusion-weighted imaging
Fractional anisotropy
Ischemic reperfusion injury
IVIM
Liver
Mean diffusivity
MRI
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/
Citation
Journal Of Magnetic Resonance Imaging, 2009, v. 30 n. 4, p. 890-895 How to Cite?
AbstractPurpose: To investigate hepatic ischemia reperfusion injury (IRI) using diffusion tensor imaging (DTI). Materials and Methods: Ten Sprague-Dawley rats were scanned at 7 Tesla (T) with DTI using b-value of 1000 s/mm2 and 6 gradient directions before, 2 h, and 1 day after 30-min total hepatic IRI. Apparent diffusion coefficient or mean diffusivity (MD), directional diffusivities and fractional anisotropy (FA) were measured. Seven of the animals were also examined with spin-echo echo-planar diffusion-weighted imaging (DWI) with seven b-values up to 2000 s/mm2 to estimate the true diffusion coefficient (D), blood pseudodiffusion coefficient (D*), and perfusion fraction (f) using a bi-compartmental model. Results: MD 2 h after IRI (0.77 ± 0.07 × 10-3 mm2/s) was significantly lower (P < 0.01) than that before (1.03 ± 0.07 × 10-3 mm2/s) and 1 day after IRI (1.01 ± 0.05 × 10 -3 mm2/s). Meanwhile, FA 2 h after IRI (0.33 ± 0.03) was significantly higher (P < 0.01) than that before (0.21 ± 0.02) and 1 day after IRI (0.20 ± 0.02). The bi-compartmental model analysis revealed the transient decrease in D, D* and f 2 h after IRI. Liver histology showed the multifocal cell swelling 3 h after IRI and widespread cell necrosis/apoptosis 1 day after IRI. Sinusoidal narrowing and congestion of erythrocytes were also observed 3 h and 1 day after IRI. Conclusion: DTI can characterize hepatic IRI by detecting the transient change in both MD and FA. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/129233
ISSN
2015 Impact Factor: 3.25
2015 SCImago Journal Rankings: 1.683
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilCERG HKU 7642/06M
Funding Information:

Contract grant sponsor: Hong Kong Research Grant Council; Contract grant number: CERG HKU 7642/06M.

References
Errata

 

DC FieldValueLanguage
dc.contributor.authorCheung, JSen_HK
dc.contributor.authorShu, JFen_HK
dc.contributor.authorChow, AMen_HK
dc.contributor.authorHui, ESen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-12-23T08:33:48Z-
dc.date.available2010-12-23T08:33:48Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Magnetic Resonance Imaging, 2009, v. 30 n. 4, p. 890-895en_HK
dc.identifier.issn1053-1807en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129233-
dc.description.abstractPurpose: To investigate hepatic ischemia reperfusion injury (IRI) using diffusion tensor imaging (DTI). Materials and Methods: Ten Sprague-Dawley rats were scanned at 7 Tesla (T) with DTI using b-value of 1000 s/mm2 and 6 gradient directions before, 2 h, and 1 day after 30-min total hepatic IRI. Apparent diffusion coefficient or mean diffusivity (MD), directional diffusivities and fractional anisotropy (FA) were measured. Seven of the animals were also examined with spin-echo echo-planar diffusion-weighted imaging (DWI) with seven b-values up to 2000 s/mm2 to estimate the true diffusion coefficient (D), blood pseudodiffusion coefficient (D*), and perfusion fraction (f) using a bi-compartmental model. Results: MD 2 h after IRI (0.77 ± 0.07 × 10-3 mm2/s) was significantly lower (P < 0.01) than that before (1.03 ± 0.07 × 10-3 mm2/s) and 1 day after IRI (1.01 ± 0.05 × 10 -3 mm2/s). Meanwhile, FA 2 h after IRI (0.33 ± 0.03) was significantly higher (P < 0.01) than that before (0.21 ± 0.02) and 1 day after IRI (0.20 ± 0.02). The bi-compartmental model analysis revealed the transient decrease in D, D* and f 2 h after IRI. Liver histology showed the multifocal cell swelling 3 h after IRI and widespread cell necrosis/apoptosis 1 day after IRI. Sinusoidal narrowing and congestion of erythrocytes were also observed 3 h and 1 day after IRI. Conclusion: DTI can characterize hepatic IRI by detecting the transient change in both MD and FA. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/en_HK
dc.relation.ispartofJournal of Magnetic Resonance Imagingen_HK
dc.rightsJournal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.subjectDiffusion tensor imagingen_HK
dc.subjectDiffusion-weighted imagingen_HK
dc.subjectFractional anisotropyen_HK
dc.subjectIschemic reperfusion injuryen_HK
dc.subjectIVIMen_HK
dc.subjectLiveren_HK
dc.subjectMean diffusivityen_HK
dc.subjectMRIen_HK
dc.subject.meshAnimals-
dc.subject.meshAnisotropy-
dc.subject.meshDiffusion Magnetic Resonance Imaging - methods-
dc.subject.meshLiver - blood supply-
dc.subject.meshReperfusion Injury - diagnosis-
dc.titleIn vivo DTI assessment of hepatic ischemia reperfusion injury in an experimental rat modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-1807&volume=30&issue=4&spage=890&epage=895&date=2009&atitle=In+vivo+DTI+assessment+of+hepatic+ischemia+reperfusion+injury+in+an+experimental+rat+model-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmri.21917en_HK
dc.identifier.pmid19787745-
dc.identifier.scopuseid_2-s2.0-70349656769en_HK
dc.identifier.hkuros177176en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349656769&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue4en_HK
dc.identifier.spage890en_HK
dc.identifier.epage895en_HK
dc.identifier.isiWOS:000270522900027-
dc.publisher.placeUnited Statesen_HK
dc.relation.erratumdoi:10.1002/jmri.22041-
dc.identifier.scopusauthoridCheung, JS=16174280400en_HK
dc.identifier.scopusauthoridShu, JF=35312398100en_HK
dc.identifier.scopusauthoridChow, AM=16174234200en_HK
dc.identifier.scopusauthoridHui, ES=16175117100en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats