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Article: In vivo DTI assessment of hepatic ischemia reperfusion injury in an experimental rat model
Title | In vivo DTI assessment of hepatic ischemia reperfusion injury in an experimental rat model | ||||
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Authors | |||||
Keywords | Diffusion tensor imaging Diffusion-weighted imaging Fractional anisotropy Ischemic reperfusion injury IVIM Liver Mean diffusivity MRI | ||||
Issue Date | 2009 | ||||
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/ | ||||
Citation | Journal Of Magnetic Resonance Imaging, 2009, v. 30 n. 4, p. 890-895 How to Cite? | ||||
Abstract | Purpose: To investigate hepatic ischemia reperfusion injury (IRI) using diffusion tensor imaging (DTI). Materials and Methods: Ten Sprague-Dawley rats were scanned at 7 Tesla (T) with DTI using b-value of 1000 s/mm2 and 6 gradient directions before, 2 h, and 1 day after 30-min total hepatic IRI. Apparent diffusion coefficient or mean diffusivity (MD), directional diffusivities and fractional anisotropy (FA) were measured. Seven of the animals were also examined with spin-echo echo-planar diffusion-weighted imaging (DWI) with seven b-values up to 2000 s/mm2 to estimate the true diffusion coefficient (D), blood pseudodiffusion coefficient (D*), and perfusion fraction (f) using a bi-compartmental model. Results: MD 2 h after IRI (0.77 ± 0.07 × 10-3 mm2/s) was significantly lower (P < 0.01) than that before (1.03 ± 0.07 × 10-3 mm2/s) and 1 day after IRI (1.01 ± 0.05 × 10 -3 mm2/s). Meanwhile, FA 2 h after IRI (0.33 ± 0.03) was significantly higher (P < 0.01) than that before (0.21 ± 0.02) and 1 day after IRI (0.20 ± 0.02). The bi-compartmental model analysis revealed the transient decrease in D, D* and f 2 h after IRI. Liver histology showed the multifocal cell swelling 3 h after IRI and widespread cell necrosis/apoptosis 1 day after IRI. Sinusoidal narrowing and congestion of erythrocytes were also observed 3 h and 1 day after IRI. Conclusion: DTI can characterize hepatic IRI by detecting the transient change in both MD and FA. © 2009 Wiley-Liss, Inc. | ||||
Persistent Identifier | http://hdl.handle.net/10722/129233 | ||||
ISSN | 2023 Impact Factor: 3.3 2023 SCImago Journal Rankings: 1.339 | ||||
ISI Accession Number ID |
Funding Information: Contract grant sponsor: Hong Kong Research Grant Council; Contract grant number: CERG HKU 7642/06M. | ||||
References | |||||
Errata |
DC Field | Value | Language |
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dc.contributor.author | Cheung, JS | en_HK |
dc.contributor.author | Shu, JF | en_HK |
dc.contributor.author | Chow, AM | en_HK |
dc.contributor.author | Hui, ES | en_HK |
dc.contributor.author | Wu, EX | en_HK |
dc.date.accessioned | 2010-12-23T08:33:48Z | - |
dc.date.available | 2010-12-23T08:33:48Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Journal Of Magnetic Resonance Imaging, 2009, v. 30 n. 4, p. 890-895 | en_HK |
dc.identifier.issn | 1053-1807 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/129233 | - |
dc.description.abstract | Purpose: To investigate hepatic ischemia reperfusion injury (IRI) using diffusion tensor imaging (DTI). Materials and Methods: Ten Sprague-Dawley rats were scanned at 7 Tesla (T) with DTI using b-value of 1000 s/mm2 and 6 gradient directions before, 2 h, and 1 day after 30-min total hepatic IRI. Apparent diffusion coefficient or mean diffusivity (MD), directional diffusivities and fractional anisotropy (FA) were measured. Seven of the animals were also examined with spin-echo echo-planar diffusion-weighted imaging (DWI) with seven b-values up to 2000 s/mm2 to estimate the true diffusion coefficient (D), blood pseudodiffusion coefficient (D*), and perfusion fraction (f) using a bi-compartmental model. Results: MD 2 h after IRI (0.77 ± 0.07 × 10-3 mm2/s) was significantly lower (P < 0.01) than that before (1.03 ± 0.07 × 10-3 mm2/s) and 1 day after IRI (1.01 ± 0.05 × 10 -3 mm2/s). Meanwhile, FA 2 h after IRI (0.33 ± 0.03) was significantly higher (P < 0.01) than that before (0.21 ± 0.02) and 1 day after IRI (0.20 ± 0.02). The bi-compartmental model analysis revealed the transient decrease in D, D* and f 2 h after IRI. Liver histology showed the multifocal cell swelling 3 h after IRI and widespread cell necrosis/apoptosis 1 day after IRI. Sinusoidal narrowing and congestion of erythrocytes were also observed 3 h and 1 day after IRI. Conclusion: DTI can characterize hepatic IRI by detecting the transient change in both MD and FA. © 2009 Wiley-Liss, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/1053-1807/ | en_HK |
dc.relation.ispartof | Journal of Magnetic Resonance Imaging | en_HK |
dc.rights | Journal of Magnetic Resonance Imaging. Copyright © John Wiley & Sons, Inc. | - |
dc.rights | Special Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.) | - |
dc.subject | Diffusion tensor imaging | en_HK |
dc.subject | Diffusion-weighted imaging | en_HK |
dc.subject | Fractional anisotropy | en_HK |
dc.subject | Ischemic reperfusion injury | en_HK |
dc.subject | IVIM | en_HK |
dc.subject | Liver | en_HK |
dc.subject | Mean diffusivity | en_HK |
dc.subject | MRI | en_HK |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Anisotropy | - |
dc.subject.mesh | Diffusion Magnetic Resonance Imaging - methods | - |
dc.subject.mesh | Liver - blood supply | - |
dc.subject.mesh | Reperfusion Injury - diagnosis | - |
dc.title | In vivo DTI assessment of hepatic ischemia reperfusion injury in an experimental rat model | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1053-1807&volume=30&issue=4&spage=890&epage=895&date=2009&atitle=In+vivo+DTI+assessment+of+hepatic+ischemia+reperfusion+injury+in+an+experimental+rat+model | - |
dc.identifier.email | Wu, EX:ewu1@hkucc.hku.hk | en_HK |
dc.identifier.authority | Wu, EX=rp00193 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/jmri.21917 | en_HK |
dc.identifier.pmid | 19787745 | - |
dc.identifier.scopus | eid_2-s2.0-70349656769 | en_HK |
dc.identifier.hkuros | 177176 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-70349656769&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 30 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 890 | en_HK |
dc.identifier.epage | 895 | en_HK |
dc.identifier.isi | WOS:000270522900027 | - |
dc.publisher.place | United States | en_HK |
dc.relation.erratum | doi:10.1002/jmri.22041 | - |
dc.identifier.scopusauthorid | Cheung, JS=16174280400 | en_HK |
dc.identifier.scopusauthorid | Shu, JF=35312398100 | en_HK |
dc.identifier.scopusauthorid | Chow, AM=16174234200 | en_HK |
dc.identifier.scopusauthorid | Hui, ES=16175117100 | en_HK |
dc.identifier.scopusauthorid | Wu, EX=7202128034 | en_HK |
dc.identifier.issnl | 1053-1807 | - |