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Article: Enhancement of gas-filled microbubble R2* by iron oxide nanoparticles for MRI

TitleEnhancement of gas-filled microbubble R2* by iron oxide nanoparticles for MRI
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2010, v. 63 n. 1, p. 224-229 How to Cite?
AbstractGas-filled microbubbles have the potential to become a unique intravascular MR contrast agent due to their magnetic susceptibility effect, biocompatibility, and localized manipulation via ultrasound cavitation. However, microbubble susceptibility effect is relatively weak when compared with other intravascular MR susceptibility contrast agents. In this study, enhancement of microbubble susceptibility effect by entrapping monocrystalline iron oxide nanoparticles (MIONs) into polymeric microbubbles was investigated at 7 T in vitro. Apparent T2 enhancement (ΔR2*) induced by microbubbles was measured to be 79.2 ± 17.5 sec-1 and 301.2 ± 16.8 sec-1 for MION-free and MION-entrapped polymeric microbubbles at 5% volume fraction, respectively. ΔR2* and apparent transverse relaxivities (r2*) for MION-entrapped polymeric microbubbles and MION-entrapped solid microspheres (without gas core) were also compared, showing the synergistic effect of the gas core with MIONs. This is the first experimental demonstration of microbubble susceptibility enhancement for MRI application. This study indicates that gas-filled polymeric microbubble susceptibility effect can be substantially increased by incorporating iron oxide nanoparticles into microbubble shells. With such an approach, microbubbles can potentially be visualized with higher sensitivity and lower concentrations by MRI. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/129195
ISSN
2015 Impact Factor: 3.782
2015 SCImago Journal Rankings: 2.197
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilCERG HKU 7642/06M
Funding Information:

Grant sponsor: Hong Kong Research Grant Council; Grant number: CERG HKU 7642/06M.

References

 

DC FieldValueLanguage
dc.contributor.authorChow, AMen_HK
dc.contributor.authorChan, KWYen_HK
dc.contributor.authorCheung, JSen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-12-23T08:33:31Z-
dc.date.available2010-12-23T08:33:31Z-
dc.date.issued2010en_HK
dc.identifier.citationMagnetic Resonance In Medicine, 2010, v. 63 n. 1, p. 224-229en_HK
dc.identifier.issn0740-3194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129195-
dc.description.abstractGas-filled microbubbles have the potential to become a unique intravascular MR contrast agent due to their magnetic susceptibility effect, biocompatibility, and localized manipulation via ultrasound cavitation. However, microbubble susceptibility effect is relatively weak when compared with other intravascular MR susceptibility contrast agents. In this study, enhancement of microbubble susceptibility effect by entrapping monocrystalline iron oxide nanoparticles (MIONs) into polymeric microbubbles was investigated at 7 T in vitro. Apparent T2 enhancement (ΔR2*) induced by microbubbles was measured to be 79.2 ± 17.5 sec-1 and 301.2 ± 16.8 sec-1 for MION-free and MION-entrapped polymeric microbubbles at 5% volume fraction, respectively. ΔR2* and apparent transverse relaxivities (r2*) for MION-entrapped polymeric microbubbles and MION-entrapped solid microspheres (without gas core) were also compared, showing the synergistic effect of the gas core with MIONs. This is the first experimental demonstration of microbubble susceptibility enhancement for MRI application. This study indicates that gas-filled polymeric microbubble susceptibility effect can be substantially increased by incorporating iron oxide nanoparticles into microbubble shells. With such an approach, microbubbles can potentially be visualized with higher sensitivity and lower concentrations by MRI. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_HK
dc.relation.ispartofMagnetic Resonance in Medicineen_HK
dc.subject.meshFerumoxytol - chemistry - diagnostic useen_HK
dc.subject.meshGases - chemistryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Enhancement - methodsen_HK
dc.subject.meshMagnetic Resonance Imaging - instrumentation - methodsen_HK
dc.subject.meshMicrobubblesen_HK
dc.subject.meshNanoparticles - chemistry - diagnostic useen_HK
dc.subject.meshPhantoms, Imagingen_HK
dc.subject.meshReproducibility of Resultsen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.titleEnhancement of gas-filled microbubble R2* by iron oxide nanoparticles for MRIen_HK
dc.typeArticleen_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mrm.22184en_HK
dc.identifier.pmid19953509-
dc.identifier.scopuseid_2-s2.0-73349084252en_HK
dc.identifier.hkuros177187en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73349084252&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue1en_HK
dc.identifier.spage224en_HK
dc.identifier.epage229en_HK
dc.identifier.isiWOS:000273578600024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChow, AM=16174234200en_HK
dc.identifier.scopusauthoridChan, KWY=35763564900en_HK
dc.identifier.scopusauthoridCheung, JS=16174280400en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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