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Article: Breathhold multiecho fast spin-echo pulse sequence for accurate R2 measurement in the heart and liver

TitleBreathhold multiecho fast spin-echo pulse sequence for accurate R2 measurement in the heart and liver
Authors
KeywordsCPMG
FSE
Heart
Liver
MRI
R2
T2
Issue Date2009
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2009, v. 62 n. 2, p. 300-306 How to Cite?
AbstractMeasurement of proton transverse relaxation rates (R 2) is a generally useful means for quantitative characterization of pathological changes in tissue with a variety of clinical applications. The most widely used R 2 measurement method is the Carr-Purcell-Meiboom-Gill (CPMG) pulse sequence but its relatively long scan time requires respiratory gating for chest or body MRI, rendering this approach impractical for comprehensive assessment within a clinically-acceptable examination time. The purpose of our study was to develop a breathhold multiecho fast spin-echo (FSE) sequence for accurate measurement of R 2 in the liver and heart. Phantom experiments and studies of subjects in vivo were performed to compare the FSE data with the corresponding even-echo CPMG data. For pooled data, the R 2 measurements were strongly correlated (Pearson correlation coefficient = 0.99) and in excellent agreement (mean difference [CPMG - FSE] = 0.10 s -1; 95% limits of agreement were 1.98 and -1.78 s -1) between the two pulse sequences. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/129193
ISSN
2015 Impact Factor: 3.782
2015 SCImago Journal Rankings: 2.197
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of HealthR01-DK069373
R01-DK066251
R37-DK049108
R01-DK049108
American Heart Association0730143N
Hong Kong Research Grant CouncilGRF7794/07M
Funding Information:

Grant sponsor: National Institutes of Health; Grant numbers: R01-DK069373, R01-DK066251, R37-DK049108, R01-DK049108; Grant sponsor: American Heart Association; Grant number: 0730143N; Grant sponsor: Hong Kong Research Grant Council; Grant number: GRF7794/07M.

References

 

DC FieldValueLanguage
dc.contributor.authorKim, Den_HK
dc.contributor.authorJensen, JHen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorSheth, SSen_HK
dc.contributor.authorBrittenham, GMen_HK
dc.date.accessioned2010-12-23T08:33:30Z-
dc.date.available2010-12-23T08:33:30Z-
dc.date.issued2009en_HK
dc.identifier.citationMagnetic Resonance In Medicine, 2009, v. 62 n. 2, p. 300-306en_HK
dc.identifier.issn0740-3194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129193-
dc.description.abstractMeasurement of proton transverse relaxation rates (R 2) is a generally useful means for quantitative characterization of pathological changes in tissue with a variety of clinical applications. The most widely used R 2 measurement method is the Carr-Purcell-Meiboom-Gill (CPMG) pulse sequence but its relatively long scan time requires respiratory gating for chest or body MRI, rendering this approach impractical for comprehensive assessment within a clinically-acceptable examination time. The purpose of our study was to develop a breathhold multiecho fast spin-echo (FSE) sequence for accurate measurement of R 2 in the liver and heart. Phantom experiments and studies of subjects in vivo were performed to compare the FSE data with the corresponding even-echo CPMG data. For pooled data, the R 2 measurements were strongly correlated (Pearson correlation coefficient = 0.99) and in excellent agreement (mean difference [CPMG - FSE] = 0.10 s -1; 95% limits of agreement were 1.98 and -1.78 s -1) between the two pulse sequences. © 2009 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_HK
dc.relation.ispartofMagnetic Resonance in Medicineen_HK
dc.rightsMagnetic Resonance in Medicine. Copyright © John Wiley & Sons, Inc.-
dc.subjectCPMGen_HK
dc.subjectFSEen_HK
dc.subjectHearten_HK
dc.subjectLiveren_HK
dc.subjectMRIen_HK
dc.subjectR2en_HK
dc.subjectT2en_HK
dc.subject.meshAlgorithms-
dc.subject.meshEcho-Planar Imaging - methods-
dc.subject.meshImage Enhancement - methods-
dc.subject.meshImage Interpretation, Computer-Assisted - methods-
dc.subject.meshLiver - pathology-
dc.titleBreathhold multiecho fast spin-echo pulse sequence for accurate R2 measurement in the heart and liveren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0740-3194&volume=62&issue=2&spage=300&epage=306&date=2009&atitle=Breath-hold+multi-echo+FSE+pulse+sequence+for+accurate+R2+measurement+in+the+heart+and+liver-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/mrm.22047en_HK
dc.identifier.pmid19526516-
dc.identifier.pmcidPMC2733943-
dc.identifier.scopuseid_2-s2.0-67749099704en_HK
dc.identifier.hkuros178255en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67749099704&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume62en_HK
dc.identifier.issue2en_HK
dc.identifier.spage300en_HK
dc.identifier.epage306en_HK
dc.identifier.isiWOS:000268432400004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKim, D=8524290700en_HK
dc.identifier.scopusauthoridJensen, JH=7404521984en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridSheth, SS=7102603512en_HK
dc.identifier.scopusauthoridBrittenham, GM=36155186400en_HK

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