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Article: SNPs of Fc-gamma receptor genes and chronic periodontitis

TitleSNPs of Fc-gamma receptor genes and chronic periodontitis
Authors
KeywordsChronic periodontitis
IgG.
Polymorphisms
Receptors
Single-nucleotide
Smoking
Issue Date2010
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
Citation
Journal Of Dental Research, 2010, v. 89 n. 7, p. 705-710 How to Cite?
AbstractGenetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 (p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis (p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese.
Persistent Identifierhttp://hdl.handle.net/10722/129103
ISSN
2014 Impact Factor: 4.139
2013 SCImago Journal Rankings: 1.492
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong10206094
10207348
Funding Information:

The studies were supported by University Research Committee grants 10206094 and 10207348 of The University of Hong Kong. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance, and Bernard Liang for orthopantomography screening.

References

 

DC FieldValueLanguage
dc.contributor.authorChai, Len_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorZee, KYen_HK
dc.contributor.authorLeung, WKen_HK
dc.date.accessioned2010-12-23T08:32:32Z-
dc.date.available2010-12-23T08:32:32Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Dental Research, 2010, v. 89 n. 7, p. 705-710en_HK
dc.identifier.issn0022-0345en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129103-
dc.description.abstractGenetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 (p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis (p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese.en_HK
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925en_HK
dc.relation.ispartofJournal of Dental Researchen_HK
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc..-
dc.subjectChronic periodontitisen_HK
dc.subjectIgG.en_HK
dc.subjectPolymorphismsen_HK
dc.subjectReceptorsen_HK
dc.subjectSingle-nucleotideen_HK
dc.subjectSmokingen_HK
dc.subject.meshAdenine-
dc.subject.meshAdult-
dc.subject.meshChronic Periodontitis - genetics-
dc.subject.meshPolymorphism, Single Nucleotide - genetics-
dc.subject.meshReceptors, IgG - genetics-
dc.titleSNPs of Fc-gamma receptor genes and chronic periodontitisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-0345&volume=89&issue=7&spage=705&epage=710&date=2010&atitle=SNPs+of+Fc-gamma+receptor+genes+and+chronic+periodontitis-
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_HK
dc.identifier.emailLeung, WK:ewkleung@hkucc.hku.hken_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/0022034510365444en_HK
dc.identifier.pmid20439936en_HK
dc.identifier.scopuseid_2-s2.0-77953791580en_HK
dc.identifier.hkuros178586en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953791580&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume89en_HK
dc.identifier.issue7en_HK
dc.identifier.spage705en_HK
dc.identifier.epage710en_HK
dc.identifier.eissn1544-0591-
dc.identifier.isiWOS:000278829300009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChai, L=36196100600en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridZee, KY=6603722366en_HK
dc.identifier.scopusauthoridLeung, WK=25224691800en_HK

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