Article: SNPs of Fc-gamma receptor genes and chronic periodontitis
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- Publisher Website: 10.1177/0022034510365444
- Scopus: eid_2-s2.0-77953791580
- PMID: 20439936
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| Title | SNPs of Fc-gamma receptor genes and chronic periodontitis | ||||
|---|---|---|---|---|---|
| Authors | Chai, L2 Song, YQ1 Zee, KY2 3 Leung, WK2 | ||||
| Keywords | Chronic periodontitis IgG. Polymorphisms Receptors Single-nucleotide Smoking | ||||
| Issue Date | 2010 | ||||
| Publisher | Sage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925 | ||||
| Citation | Journal Of Dental Research, 2010, v. 89 n. 7, p. 705-710 [How to Cite?] DOI: http://dx.doi.org/10.1177/0022034510365444 | ||||
| Abstract | Genetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 (p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis (p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese. | ||||
| ISSN | 0022-0345 2011 Impact Factor: 3.486 2011 SCImago Journal Rankings: 0.220 | ||||
| DOI | http://dx.doi.org/10.1177/0022034510365444 | ||||
| ISI Accession Number ID | WOS:000278829300009
Funding Information: The studies were supported by University Research Committee grants 10206094 and 10207348 of The University of Hong Kong. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance, and Bernard Liang for orthopantomography screening. | ||||
| References | References in Scopus |
| dc.contributor.author | Chai, L | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Song, YQ | ||||
| dc.contributor.author | Zee, KY | ||||
| dc.contributor.author | Leung, WK | ||||
| dc.date.accessioned | 2010-12-23T08:32:32Z | ||||
| dc.date.available | 2010-12-23T08:32:32Z | ||||
| dc.date.issued | 2010 | ||||
| dc.description.abstract | Genetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 (p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis (p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese. | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Journal Of Dental Research, 2010, v. 89 n. 7, p. 705-710 [How to Cite?] DOI: http://dx.doi.org/10.1177/0022034510365444 | ||||
| dc.identifier.doi | http://dx.doi.org/10.1177/0022034510365444 | ||||
| dc.identifier.epage | 710 | ||||
| dc.identifier.hkuros | 178586 | ||||
| dc.identifier.isi | WOS:000278829300009
Funding Information: The studies were supported by University Research Committee grants 10206094 and 10207348 of The University of Hong Kong. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance, and Bernard Liang for orthopantomography screening. | ||||
| dc.identifier.issn | 0022-0345 2011 Impact Factor: 3.486 2011 SCImago Journal Rankings: 0.220 | ||||
| dc.identifier.issue | 7 | ||||
| dc.identifier.openurl | | ||||
| dc.identifier.pmid | 20439936 | ||||
| dc.identifier.scopus | eid_2-s2.0-77953791580 | ||||
| dc.identifier.spage | 705 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/129103 | ||||
| dc.identifier.volume | 89 | ||||
| dc.language | eng | ||||
| dc.publisher | Sage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925 | ||||
| dc.publisher.place | United States | ||||
| dc.relation.ispartof | Journal of Dental Research | ||||
| dc.relation.references | References in Scopus | ||||
| dc.rights | Journal of Dental Research. Copyright © Sage Publications, Inc.. | ||||
| dc.subject.mesh | Adenine | ||||
| dc.subject.mesh | Adult | ||||
| dc.subject.mesh | Chronic Periodontitis - genetics | ||||
| dc.subject.mesh | Polymorphism, Single Nucleotide - genetics | ||||
| dc.subject.mesh | Receptors, IgG - genetics | ||||
| dc.subject | Chronic periodontitis | ||||
| dc.subject | IgG. | ||||
| dc.subject | Polymorphisms | ||||
| dc.subject | Receptors | ||||
| dc.subject | Single-nucleotide | ||||
| dc.subject | Smoking | ||||
| dc.title | SNPs of Fc-gamma receptor genes and chronic periodontitis | ||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- Prince Philip Dental Hospital
- Westmead Hospital