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Article: SNPs of Fc-gamma receptor genes and chronic periodontitis
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TitleSNPs of Fc-gamma receptor genes and chronic periodontitis
 
AuthorsChai, L2
Song, YQ1
Zee, KY2 3
Leung, WK2
 
KeywordsChronic periodontitis
IgG.
Polymorphisms
Receptors
Single-nucleotide
Smoking
 
Issue Date2010
 
PublisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
 
CitationJournal Of Dental Research, 2010, v. 89 n. 7, p. 705-710 [How to Cite?]
DOI: http://dx.doi.org/10.1177/0022034510365444
 
AbstractGenetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 (p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis (p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese.
 
ISSN0022-0345
2013 Impact Factor: 4.144
2013 SCImago Journal Rankings: 1.492
 
DOIhttp://dx.doi.org/10.1177/0022034510365444
 
ISI Accession Number IDWOS:000278829300009
Funding AgencyGrant Number
University of Hong Kong10206094
10207348
Funding Information:

The studies were supported by University Research Committee grants 10206094 and 10207348 of The University of Hong Kong. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance, and Bernard Liang for orthopantomography screening.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChai, L
 
dc.contributor.authorSong, YQ
 
dc.contributor.authorZee, KY
 
dc.contributor.authorLeung, WK
 
dc.date.accessioned2010-12-23T08:32:32Z
 
dc.date.available2010-12-23T08:32:32Z
 
dc.date.issued2010
 
dc.description.abstractGenetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 (p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis (p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Dental Research, 2010, v. 89 n. 7, p. 705-710 [How to Cite?]
DOI: http://dx.doi.org/10.1177/0022034510365444
 
dc.identifier.doihttp://dx.doi.org/10.1177/0022034510365444
 
dc.identifier.eissn1544-0591
 
dc.identifier.epage710
 
dc.identifier.hkuros178586
 
dc.identifier.isiWOS:000278829300009
Funding AgencyGrant Number
University of Hong Kong10206094
10207348
Funding Information:

The studies were supported by University Research Committee grants 10206094 and 10207348 of The University of Hong Kong. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance, and Bernard Liang for orthopantomography screening.

 
dc.identifier.issn0022-0345
2013 Impact Factor: 4.144
2013 SCImago Journal Rankings: 1.492
 
dc.identifier.issue7
 
dc.identifier.openurl
 
dc.identifier.pmid20439936
 
dc.identifier.scopuseid_2-s2.0-77953791580
 
dc.identifier.spage705
 
dc.identifier.urihttp://hdl.handle.net/10722/129103
 
dc.identifier.volume89
 
dc.languageeng
 
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201925
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Dental Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Dental Research. Copyright © Sage Publications, Inc..
 
dc.subject.meshAdenine
 
dc.subject.meshAdult
 
dc.subject.meshChronic Periodontitis - genetics
 
dc.subject.meshPolymorphism, Single Nucleotide - genetics
 
dc.subject.meshReceptors, IgG - genetics
 
dc.subjectChronic periodontitis
 
dc.subjectIgG.
 
dc.subjectPolymorphisms
 
dc.subjectReceptors
 
dc.subjectSingle-nucleotide
 
dc.subjectSmoking
 
dc.titleSNPs of Fc-gamma receptor genes and chronic periodontitis
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Prince Philip Dental Hospital
  3. Westmead Hospital