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Article: Single nucleotide polymorphisms of complement component 5 and periodontitis

TitleSingle nucleotide polymorphisms of complement component 5 and periodontitis
Authors
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
Citation
Journal of Periodontal Research, 2010, v. 45 n. 3, p. 301-308 How to Cite?
AbstractBACKGROUND AND OBJECTIVE: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. MATERIAL AND METHODS: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system. RESULTS: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006). CONCLUSION: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/129097
ISSN
2014 Impact Factor: 2.466
ISI Accession Number ID
Funding AgencyGrant Number
University Research Committee10206094
10207348
Funding Information:

This study was supported by University Research Committee grants 10206094 and 10207348. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance during sequencing and Bernard Liang for orthopantomograph screening.

References

 

DC FieldValueLanguage
dc.contributor.authorChai, Len_US
dc.contributor.authorSong, YQen_US
dc.contributor.authorZee, KYen_US
dc.contributor.authorLeung, WKen_US
dc.date.accessioned2010-12-23T08:32:27Z-
dc.date.available2010-12-23T08:32:27Z-
dc.date.issued2010en_US
dc.identifier.citationJournal of Periodontal Research, 2010, v. 45 n. 3, p. 301-308en_US
dc.identifier.issn0022-3484-
dc.identifier.urihttp://hdl.handle.net/10722/129097-
dc.description.abstractBACKGROUND AND OBJECTIVE: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. MATERIAL AND METHODS: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system. RESULTS: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006). CONCLUSION: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.-
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1-
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdenine-
dc.subject.meshComplement C5 - genetics-
dc.subject.meshImmunologic Factors - genetics-
dc.subject.meshPeriodontitis - genetics - immunology-
dc.subject.meshPolymorphism, Single Nucleotide - genetics-
dc.titleSingle nucleotide polymorphisms of complement component 5 and periodontitisen_US
dc.typeArticleen_US
dc.identifier.emailChai, L: rleichai@gmail.comen_US
dc.identifier.emailSong, YQ: songy@hkucc.hku.hken_US
dc.identifier.emailZee, KY: kyzee@hkusub.hku.hken_US
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hken_US
dc.identifier.authoritySong, YQ=rp00488en_US
dc.identifier.authorityLeung, WK=rp00019en_US
dc.description.naturepostprint-
dc.identifier.doi10.1111/j.1600-0765.2009.01234.x-
dc.identifier.pmid19909405-
dc.identifier.scopuseid_2-s2.0-77953150872-
dc.identifier.hkuros178589en_US
dc.identifier.hkuros169721-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953150872&selection=ref&src=s&origin=recordpage-
dc.identifier.volume45en_US
dc.identifier.issue3en_US
dc.identifier.spage301en_US
dc.identifier.epage308en_US
dc.identifier.isiWOS:000276699300001-
dc.publisher.placeUnited States-
dc.identifier.scopusauthoridChai, L=36196100600-
dc.identifier.scopusauthoridSong, YQ=7404921212-
dc.identifier.scopusauthoridZee, KY=6603722366-
dc.identifier.scopusauthoridLeung, WK=25224691800-

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