Article: Single nucleotide polymorphisms of complement component 5 and periodontitis
| Title | Single nucleotide polymorphisms of complement component 5 and periodontitis | ||||
|---|---|---|---|---|---|
| Authors | Chai, L2 Song, YQ1 Zee, KY2 Leung, WK2 | ||||
| Issue Date | 2010 | ||||
| Publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1 | ||||
| Citation | Journal of Periodontal Research, 2010, v. 45 n. 3, p. 301-308 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1600-0765.2009.01234.x | ||||
| Abstract | BACKGROUND AND OBJECTIVE: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. MATERIAL AND METHODS: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system. RESULTS: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006). CONCLUSION: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population. | ||||
| ISSN | 0022-3484 2011 Impact Factor: 1.686 2011 SCImago Journal Rankings: 0.120 | ||||
| DOI | http://dx.doi.org/10.1111/j.1600-0765.2009.01234.x | ||||
| ISI Accession Number ID | WOS:000276699300001
Funding Information: This study was supported by University Research Committee grants 10206094 and 10207348. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance during sequencing and Bernard Liang for orthopantomograph screening. | ||||
| References | References in Scopus |
| dc.contributor.author | Chai, L | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Song, YQ | ||||
| dc.contributor.author | Zee, KY | ||||
| dc.contributor.author | Leung, WK | ||||
| dc.date.accessioned | 2010-12-23T08:32:27Z | ||||
| dc.date.available | 2010-12-23T08:32:27Z | ||||
| dc.date.issued | 2010 | ||||
| dc.description.abstract | BACKGROUND AND OBJECTIVE: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. MATERIAL AND METHODS: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system. RESULTS: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006). CONCLUSION: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population. | ||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||
| dc.identifier.citation | Journal of Periodontal Research, 2010, v. 45 n. 3, p. 301-308 [How to Cite?] DOI: http://dx.doi.org/10.1111/j.1600-0765.2009.01234.x | ||||
| dc.identifier.doi | http://dx.doi.org/10.1111/j.1600-0765.2009.01234.x | ||||
| dc.identifier.epage | 308 | ||||
| dc.identifier.hkuros | 178589 | ||||
| dc.identifier.hkuros | 169721 | ||||
| dc.identifier.isi | WOS:000276699300001
Funding Information: This study was supported by University Research Committee grants 10206094 and 10207348. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance during sequencing and Bernard Liang for orthopantomograph screening. | ||||
| dc.identifier.issn | 0022-3484 2011 Impact Factor: 1.686 2011 SCImago Journal Rankings: 0.120 | ||||
| dc.identifier.issue | 3 | ||||
| dc.identifier.pmid | 19909405 | ||||
| dc.identifier.scopus | eid_2-s2.0-77953150872 | ||||
| dc.identifier.spage | 301 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/129097 | ||||
| dc.identifier.volume | 45 | ||||
| dc.language | eng | ||||
| dc.publisher | Wiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1 | ||||
| dc.publisher.place | United States | ||||
| dc.relation.ispartof | Journal of Periodontal Research | ||||
| dc.relation.references | References in Scopus | ||||
| dc.rights | The definitive version is available at www3.interscience.wiley.com | ||||
| dc.subject.mesh | Adenine | ||||
| dc.subject.mesh | Complement C5 - genetics | ||||
| dc.subject.mesh | Immunologic Factors - genetics | ||||
| dc.subject.mesh | Periodontitis - genetics - immunology | ||||
| dc.subject.mesh | Polymorphism, Single Nucleotide - genetics | ||||
| dc.title | Single nucleotide polymorphisms of complement component 5 and periodontitis | ||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- The University of Hong Kong