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Article: Single nucleotide polymorphisms of complement component 5 and periodontitis
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TitleSingle nucleotide polymorphisms of complement component 5 and periodontitis
 
AuthorsChai, L2
Song, YQ1
Zee, KY2
Leung, WK2
 
Issue Date2010
 
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
 
CitationJournal of Periodontal Research, 2010, v. 45 n. 3, p. 301-308 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0765.2009.01234.x
 
AbstractBACKGROUND AND OBJECTIVE: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. MATERIAL AND METHODS: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system. RESULTS: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006). CONCLUSION: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.
 
ISSN0022-3484
2012 Impact Factor: 1.99
2012 SCImago Journal Rankings: 0.596
 
DOIhttp://dx.doi.org/10.1111/j.1600-0765.2009.01234.x
 
ISI Accession Number IDWOS:000276699300001
Funding AgencyGrant Number
University Research Committee10206094
10207348
Funding Information:

This study was supported by University Research Committee grants 10206094 and 10207348. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance during sequencing and Bernard Liang for orthopantomograph screening.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChai, L
 
dc.contributor.authorSong, YQ
 
dc.contributor.authorZee, KY
 
dc.contributor.authorLeung, WK
 
dc.date.accessioned2010-12-23T08:32:27Z
 
dc.date.available2010-12-23T08:32:27Z
 
dc.date.issued2010
 
dc.description.abstractBACKGROUND AND OBJECTIVE: Polymorphisms of host defence genes might increase one's risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. MATERIAL AND METHODS: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system. RESULTS: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006). CONCLUSION: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.
 
dc.description.naturepostprint
 
dc.identifier.citationJournal of Periodontal Research, 2010, v. 45 n. 3, p. 301-308 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0765.2009.01234.x
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0765.2009.01234.x
 
dc.identifier.epage308
 
dc.identifier.hkuros178589
 
dc.identifier.hkuros169721
 
dc.identifier.isiWOS:000276699300001
Funding AgencyGrant Number
University Research Committee10206094
10207348
Funding Information:

This study was supported by University Research Committee grants 10206094 and 10207348. We thank Trevor Lane for manuscript editing, Alan Wong for technical assistance during sequencing and Bernard Liang for orthopantomograph screening.

 
dc.identifier.issn0022-3484
2012 Impact Factor: 1.99
2012 SCImago Journal Rankings: 0.596
 
dc.identifier.issue3
 
dc.identifier.pmid19909405
 
dc.identifier.scopuseid_2-s2.0-77953150872
 
dc.identifier.spage301
 
dc.identifier.urihttp://hdl.handle.net/10722/129097
 
dc.identifier.volume45
 
dc.languageeng
 
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Periodontal Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsThe definitive version is available at www3.interscience.wiley.com
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAdenine
 
dc.subject.meshComplement C5 - genetics
 
dc.subject.meshImmunologic Factors - genetics
 
dc.subject.meshPeriodontitis - genetics - immunology
 
dc.subject.meshPolymorphism, Single Nucleotide - genetics
 
dc.titleSingle nucleotide polymorphisms of complement component 5 and periodontitis
 
dc.typeArticle
 
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<description.abstract>BACKGROUND AND OBJECTIVE: Polymorphisms of host defence genes might increase one&apos;s risks for periodontitis. This study investigated whether tagging single nucleotide polymorphisms (SNPs) of the gene encoding complement component 5 (C5) are associated with periodontitis in a Hong Kong Chinese population. MATERIAL AND METHODS: Eleven tagging SNPs of 229 patients with at least moderate periodontitis and 207 control subjects without periodontitis were genotyped using an i-plexGOLD MassARRAY mass-spectrometry system. RESULTS: Genotype AG of SNP rs17611 was more prevalent in the group of periodontitis patients than in the controls (54.6% vs. 41.7%, p = 0.007). The haplotype CGCA of the haplotype block consisting of rs1035029, rs17611, rs25681 and rs992670 was significantly associated with periodontitis in a dominant model (p = 0.001). The SNP rs17611 showed high linkage disequilibrium with rs1035029, rs25681 and rs992670. Smoking was also significantly associated with periodontitis (p = 0.006). CONCLUSION: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong