File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Spatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injury

TitleSpatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injury
Authors
Keywordsaffective
amygdala
anterior cingulate cortex
Neuropathic pain
NF-κB
somatosensory cortex
thalamus
Issue Date2011
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jpain
Citation
Journal Of Pain, 2011, v. 12 n. 1, p. 13-21 How to Cite?
AbstractThe expression of NF-κB in the spinal cord is associated with neuropathic pain. However, little is known about its expression beyond the spinal cord. Here we examined a spatial and temporal pattern of the NF-κB expression in both spinal and supraspinal regions. After chronic constriction injury (CCI) of the sciatic nerve, NF-κB (p65) expression was significantly increased in the ipsilateral spinal cord. In contrast, the NF-κB expression in the contralateral primary somatosensory cortex was decreased with no significant differences seen in the thalamus. In the contralateral anterior cingulate cortex, the NF-κB expression was increased significantly on day 14 as compared with the sham group. In the contralateral amygdala, the NF-κB expression showed a time-dependent downregulation after CCI, which became significant on day 14. MK-801 reduced nociceptive behaviors and reversed the direction of NF-κB expression. These results indicate that the CCI-induced expression of p65 NF-κB is both time-dependent and region-specific, in areas that process both sensory-discriminative and motivational-affective dimensions of pain. Perspective: This article presents a spatiotemporal mapping of the NF-κB expression in spinal and supraspinal regions after peripheral nerve injury. These findings point to an involvement of NF-κB beyond the spinal cord in both the sensory discriminative and emotional affective aspects of neuropathic pain processing. © 2011 by the American Pain Society.
Persistent Identifierhttp://hdl.handle.net/10722/129083
ISSN
2015 Impact Factor: 4.463
2015 SCImago Journal Rankings: 2.124
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
NIHDE18214
DE18538
NS45681
Funding Information:

Supported by NIH RO1 grants DE18214, DE18538, and NS45681.

References

 

DC FieldValueLanguage
dc.contributor.authorChou, CWen_HK
dc.contributor.authorWong, GTCen_HK
dc.contributor.authorLim, Gen_HK
dc.contributor.authorWang, Sen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorMao, Jen_HK
dc.date.accessioned2010-12-23T08:32:15Z-
dc.date.available2010-12-23T08:32:15Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Pain, 2011, v. 12 n. 1, p. 13-21en_HK
dc.identifier.issn1526-5900en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129083-
dc.description.abstractThe expression of NF-κB in the spinal cord is associated with neuropathic pain. However, little is known about its expression beyond the spinal cord. Here we examined a spatial and temporal pattern of the NF-κB expression in both spinal and supraspinal regions. After chronic constriction injury (CCI) of the sciatic nerve, NF-κB (p65) expression was significantly increased in the ipsilateral spinal cord. In contrast, the NF-κB expression in the contralateral primary somatosensory cortex was decreased with no significant differences seen in the thalamus. In the contralateral anterior cingulate cortex, the NF-κB expression was increased significantly on day 14 as compared with the sham group. In the contralateral amygdala, the NF-κB expression showed a time-dependent downregulation after CCI, which became significant on day 14. MK-801 reduced nociceptive behaviors and reversed the direction of NF-κB expression. These results indicate that the CCI-induced expression of p65 NF-κB is both time-dependent and region-specific, in areas that process both sensory-discriminative and motivational-affective dimensions of pain. Perspective: This article presents a spatiotemporal mapping of the NF-κB expression in spinal and supraspinal regions after peripheral nerve injury. These findings point to an involvement of NF-κB beyond the spinal cord in both the sensory discriminative and emotional affective aspects of neuropathic pain processing. © 2011 by the American Pain Society.en_HK
dc.languageengen_US
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jpainen_HK
dc.relation.ispartofJournal of Painen_HK
dc.rightsA definitive version was published in The Journal of Pain, 2011, v. 12 n. 1, p. 13-21. DOI: 10.1016/j.jpain.2010.03.018-
dc.subjectaffectiveen_HK
dc.subjectamygdalaen_HK
dc.subjectanterior cingulate cortexen_HK
dc.subjectNeuropathic painen_HK
dc.subjectNF-κBen_HK
dc.subjectsomatosensory cortexen_HK
dc.subjectthalamusen_HK
dc.subject.meshGene Expression Regulation - drug effects - physiology-
dc.subject.meshNF-kappa B - metabolism-
dc.subject.meshPeripheral Nervous System Diseases - complications - metabolism - pathology-
dc.subject.meshSomatosensory Cortex - metabolism-
dc.subject.meshSpinal Cord - metabolism-
dc.titleSpatiotemporal pattern of concurrent spinal and supraspinal NF-κB expression after peripheral nerve injuryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1526-5900&volume=12&issue=1&spage=13&epage=21&date=2011&atitle=Spatiotemporal+pattern+of+concurrent+spinal+and+supraspinal+NF-κB+expression+after+peripheral+nerve+injury-
dc.identifier.emailWong, GTC:gordon@hku.hken_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityWong, GTC=rp00523en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.jpain.2010.03.018en_HK
dc.identifier.pmid20537956-
dc.identifier.pmcidPMC2978259-
dc.identifier.scopuseid_2-s2.0-78650709698en_HK
dc.identifier.hkuros184513en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650709698&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue1en_HK
dc.identifier.spage13en_HK
dc.identifier.epage21en_HK
dc.identifier.eissn1528-8447-
dc.identifier.isiWOS:000286549700003-
dc.publisher.placeUnited Statesen_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats