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Article: Immune reconstitution inflammatory syndrome after highly active antiretroviral therapy: A review

TitleImmune reconstitution inflammatory syndrome after highly active antiretroviral therapy: A review
Authors
KeywordsAIDS
HAART
HIV
Immune reconstitution inflammatory syndrome
Oral manifestations
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
Citation
Oral Diseases, 2010, v. 16 n. 3, p. 248-256 How to Cite?
AbstractThe use of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV) restores immune responses against pathogens and has greatly decreased mortality. However, in about 25% to 35% of patients receiving HAART, the reconstituted immune system leads to a pathological inflammatory response, commonly known as immune reconstitution inflammatory syndrome (IRIS), which causes substantial short-term morbidity or even mortality. Although we have gleaned some knowledge on IRIS in the past few years, a number of unanswered questions remain. In this review, we discuss the definition, diagnostic criteria, pathogenesis, risk factors, clinical spectrum including oral manifestations, and management of IRIS. © 2009 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/129080
ISSN
2015 Impact Factor: 2.0
2015 SCImago Journal Rankings: 0.828
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, CSPen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-12-23T08:32:09Z-
dc.date.available2010-12-23T08:32:09Z-
dc.date.issued2010en_HK
dc.identifier.citationOral Diseases, 2010, v. 16 n. 3, p. 248-256en_HK
dc.identifier.issn1354-523Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/129080-
dc.description.abstractThe use of highly active antiretroviral therapy (HAART) in the management of human immunodeficiency virus (HIV) restores immune responses against pathogens and has greatly decreased mortality. However, in about 25% to 35% of patients receiving HAART, the reconstituted immune system leads to a pathological inflammatory response, commonly known as immune reconstitution inflammatory syndrome (IRIS), which causes substantial short-term morbidity or even mortality. Although we have gleaned some knowledge on IRIS in the past few years, a number of unanswered questions remain. In this review, we discuss the definition, diagnostic criteria, pathogenesis, risk factors, clinical spectrum including oral manifestations, and management of IRIS. © 2009 John Wiley & Sons A/S.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1en_HK
dc.relation.ispartofOral Diseasesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectAIDSen_HK
dc.subjectHAARTen_HK
dc.subjectHIVen_HK
dc.subjectImmune reconstitution inflammatory syndromeen_HK
dc.subjectOral manifestationsen_HK
dc.subject.meshAIDS-Related Opportunistic Infections - complications-
dc.subject.meshAntiretroviral Therapy, Highly Active - adverse effects-
dc.subject.meshCandidiasis, Oral - complications-
dc.subject.meshImmune Reconstitution Inflammatory Syndrome - complications - diagnosis - etiology - therapy-
dc.subject.meshMouth Diseases - complications-
dc.titleImmune reconstitution inflammatory syndrome after highly active antiretroviral therapy: A reviewen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1354-523X&volume=16&issue=3&spage=248&epage=256&date=2010&atitle=Immune+reconstitution+inflammatory+syndrome+after+highly+active+antiretroviral+therapy:+a+review-
dc.identifier.emailTsang, CSP:csptsang@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authorityTsang, CSP=rp00026en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1111/j.1601-0825.2009.01628.xen_HK
dc.identifier.pmid19758406-
dc.identifier.scopuseid_2-s2.0-77949596806en_HK
dc.identifier.hkuros177035en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949596806&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage248en_HK
dc.identifier.epage256en_HK
dc.identifier.eissn1601-0825-
dc.identifier.isiWOS:000275644600004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsang, CSP=7202936002en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.citeulike6885113-

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