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Article: TGF-β1 interactome: Metastasis and beyond

TitleTGF-β1 interactome: Metastasis and beyond
Authors
KeywordsDiagnostics
Interactome
Metastatsis
Review
Therapeutics
Transforming growth factor-β1
Issue Date2010
PublisherInternational Institute of Anticancer Research. The Journal's web site is located at http://www.iiar-anticancer.org
Citation
Cancer Genomics And Proteomics, 2010, v. 7 n. 4, p. 217-229 How to Cite?
AbstractThe ubiquitous cytokine transforming growth factor-β1 (TGF-β1) is one of the most potent metastatic inducers. Functional interactomic mapping using high-throughput proteomic and genomic data provides valuable insights into the regulation of tumor suppressive and metastatic attributes of TGF-β1. Polarity changes of the TGF-β1 interactome at a given time contributes to these contrasting effects. Differential expression profiles of pivotal interactomic nodes contribute to these polarity changes. These insights are of immense value in the development of effective cancer therapeutics. Moreover, TGF-β1 interactomic nodes are useful in discovering novel cancer biomarkers. This review describes an initial version of the TGF-β1 interactome in relation to tumor progression and metastasis. Thus, this review embodies an important step towards the mapping of comprehensive and individualized TGF-β1 interactomes that will assist in the development of personalized cancer therapeutics.
Persistent Identifierhttp://hdl.handle.net/10722/129050
ISSN
2015 Impact Factor: 2.8
2015 SCImago Journal Rankings: 1.083
References

 

DC FieldValueLanguage
dc.contributor.authorPerera, Men_HK
dc.contributor.authorTsang, CSen_HK
dc.contributor.authorDistel, RJen_HK
dc.contributor.authorLacy, JNen_HK
dc.contributor.authorOhnoMachado, Len_HK
dc.contributor.authorRicchiuti, Ven_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorSmejkal, GBen_HK
dc.contributor.authorSmith, MGen_HK
dc.contributor.authorTrachtenberg, AJen_HK
dc.contributor.authorKuo, WPen_HK
dc.date.accessioned2010-12-23T08:31:53Z-
dc.date.available2010-12-23T08:31:53Z-
dc.date.issued2010en_HK
dc.identifier.citationCancer Genomics And Proteomics, 2010, v. 7 n. 4, p. 217-229en_HK
dc.identifier.issn1109-6535en_HK
dc.identifier.urihttp://hdl.handle.net/10722/129050-
dc.description.abstractThe ubiquitous cytokine transforming growth factor-β1 (TGF-β1) is one of the most potent metastatic inducers. Functional interactomic mapping using high-throughput proteomic and genomic data provides valuable insights into the regulation of tumor suppressive and metastatic attributes of TGF-β1. Polarity changes of the TGF-β1 interactome at a given time contributes to these contrasting effects. Differential expression profiles of pivotal interactomic nodes contribute to these polarity changes. These insights are of immense value in the development of effective cancer therapeutics. Moreover, TGF-β1 interactomic nodes are useful in discovering novel cancer biomarkers. This review describes an initial version of the TGF-β1 interactome in relation to tumor progression and metastasis. Thus, this review embodies an important step towards the mapping of comprehensive and individualized TGF-β1 interactomes that will assist in the development of personalized cancer therapeutics.en_HK
dc.languageengen_US
dc.publisherInternational Institute of Anticancer Research. The Journal's web site is located at http://www.iiar-anticancer.orgen_HK
dc.relation.ispartofCancer Genomics and Proteomicsen_HK
dc.subjectDiagnosticsen_HK
dc.subjectInteractomeen_HK
dc.subjectMetastatsisen_HK
dc.subjectReviewen_HK
dc.subjectTherapeuticsen_HK
dc.subjectTransforming growth factor-β1en_HK
dc.subject.meshAnimals-
dc.subject.meshHumans-
dc.subject.meshNeoplasms - blood supply - chemistry - metabolism - therapy-
dc.subject.meshProteome - analysis-
dc.subject.meshTransforming Growth Factor beta1 - metabolism-
dc.titleTGF-β1 interactome: Metastasis and beyonden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1109-6535&volume=7&issue=4&spage=217&epage=229&date=2010&atitle=TGF-β1+interactome:+metastasis+and+beyond-
dc.identifier.emailTsang, CS:csptsang@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authorityTsang, CS=rp00026en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid20656987-
dc.identifier.scopuseid_2-s2.0-77955947596en_HK
dc.identifier.hkuros177042en_US
dc.identifier.hkuros217044-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955947596&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue4en_HK
dc.identifier.spage217en_HK
dc.identifier.epage229en_HK
dc.publisher.placeGreeceen_HK
dc.identifier.scopusauthoridPerera, M=36483226400en_HK
dc.identifier.scopusauthoridTsang, CS=7202936002en_HK
dc.identifier.scopusauthoridDistel, RJ=7006293665en_HK
dc.identifier.scopusauthoridLacy, JN=35243082100en_HK
dc.identifier.scopusauthoridOhnoMachado, L=7005192335en_HK
dc.identifier.scopusauthoridRicchiuti, V=36483360000en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridSmejkal, GB=6701799338en_HK
dc.identifier.scopusauthoridSmith, MG=36483519200en_HK
dc.identifier.scopusauthoridTrachtenberg, AJ=36805377200en_HK
dc.identifier.scopusauthoridKuo, WP=7202113222en_HK

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