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Article: Reactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes.

TitleReactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes.
Authors
Shi, YVanhoutte, PM
Issue Date2009
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1753-0393
Citation
Journal Of Diabetes, 2009, v. 1 n. 3, p. 151-162 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1753-0407.2009.00030.x
AbstractVascular complications are an important pathological issue in diabetes that lead to the further functional deterioration of several organs. The balance between endothelium-dependent relaxing factors and endothelium-dependent contracting factors (EDCFs) is crucial in controlling local vascular tone and function under normal conditions. Diabetic endothelial dysfunction is characterized by reduced endothelium-dependent relaxations and/or enhanced endothelium-dependent contractions. Elevated levels of oxygen-derived free radicals are the initial source of endothelial dysfunction in diabetes. Oxygen-derived free radicals not only reduce nitric oxide bioavailability, but also facilitate the production and/or action of EDCFs. Thus, the endothelial balance tips towards vasoconstrictor responses over the course of diabetes. © 2009 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/128492
ISSN
1753-0407
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.951
ISI Accession Number ID
WOS:000208415100011

 

DC FieldValueLanguage
dc.contributor.authorShi, Yen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.date.accessioned2010-10-31T14:31:23Z-
dc.date.available2010-10-31T14:31:23Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Diabetes, 2009, v. 1 n. 3, p. 151-162en_HK
dc.identifier.issn1753-0407en_HK
dc.identifier.urihttp://hdl.handle.net/10722/128492-
dc.description.abstractVascular complications are an important pathological issue in diabetes that lead to the further functional deterioration of several organs. The balance between endothelium-dependent relaxing factors and endothelium-dependent contracting factors (EDCFs) is crucial in controlling local vascular tone and function under normal conditions. Diabetic endothelial dysfunction is characterized by reduced endothelium-dependent relaxations and/or enhanced endothelium-dependent contractions. Elevated levels of oxygen-derived free radicals are the initial source of endothelial dysfunction in diabetes. Oxygen-derived free radicals not only reduce nitric oxide bioavailability, but also facilitate the production and/or action of EDCFs. Thus, the endothelial balance tips towards vasoconstrictor responses over the course of diabetes. © 2009 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1753-0393-
dc.relation.ispartofJournal of diabetesen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subject.meshAntioxidants - therapeutic use-
dc.subject.meshDiabetes Mellitus - metabolism - physiopathology-
dc.subject.meshEndothelium, Vascular - physiopathology-
dc.subject.meshFree Radicals - metabolism-
dc.subject.meshReactive Oxygen Species - metabolism-
dc.titleReactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes.en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1753-0393&volume=1&issue=3&spage=151&epage=162&date=2009&atitle=Reactive+oxygen-derived+free+radicals+are+key+to+the+endothelial+dysfunction+of+diabetes-
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1111/j.1753-0407.2009.00030.x-
dc.identifier.pmid20923534-
dc.identifier.scopuseid_2-s2.0-77956386834en_HK
dc.identifier.hkuros181248en_HK
dc.identifier.volume1en_HK
dc.identifier.issue3en_HK
dc.identifier.spage151en_HK
dc.identifier.epage162en_HK
dc.identifier.isiWOS:000208415100011-
dc.identifier.scopusauthoridShi, Y=7404963998en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.citeulike8383569-
dc.identifier.issnl1753-0407-

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