The causes of the metabolic syndrome – an Asian perspective

Abstract

Due to urbanization and economic development, the metabolic syndrome has become prevalent in Asia and will be an important risk factor for cardiovascular diseases. Overeating and lack of physical activity lead to central obesity, the metabolic syndrome and cardiovascular diseases. Excess fat increases fatty acids in the blood, and also causes local and widespread inflammation. This inflammation is harmful to blood vessels and leads to endothelial dysfunction, high blood pressure and atherosclerosis. Lifestyle modification is the key to preventing the metabolic syndrome. Metformin, acarbose and glitazones may help to prevent the development of diabetes. Orlistat has a limited role for treating obesity, but there are new drugs for obesity in the pipeline.