File Download
 
 
Patent History
  • Application
    US 11/990115 2006-08-02
  • Granted
    US 8003358 2011-08-23
 
Supplementary

Granted Patent: Two-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid
  • Basic View
  • Metadata View
  • XML View
TitleTwo-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid
 
Granted PatentUS 8003358
 
Granted Date2011-08-23
 
Priority Date2005-08-08 CN20051089965
2006-08-02 PCT/CN2006001940
 
InventorsWang, J
Tsang, WK
Yap, HK
Chen, JM
Siu, YL
Tsang, SY
 
Issue Date2010
 
CitationUS Patent US 8003358. Washington, DC: US Patent and Trademark Office (USPTO), 2011 [How to Cite?]
 
AbstractThe present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 105% higher than that of parent D-amino acid oxidase. The method has no need of addition of hydrogen peroxide, [beta]-lactamase inhibitor, catalase inhibitor, catalase and the like commonly used in the prior art. The productivity of the method can reach more than 93%. Thus, the method is simple, low in cost and high in productivity.
 
ReferencesUS 7517677 (B2) 2009-04-14

US 2008009052 (A1) 2008-01-10

CN 1104255 (A) 1995-06-28

CN 1065278 (C) 2001-05-02

CN 1301813 (A) 2001-07-04

CN 1371999 (A) 2002-10-02

CN 1151261 (C) 2004-05-26

CN 1428424 (A) 2003-07-09
 
DC FieldValue
dc.contributor.inventorWang, J
 
dc.contributor.inventorTsang, WK
 
dc.contributor.inventorYap, HK
 
dc.contributor.inventorChen, JM
 
dc.contributor.inventorSiu, YL
 
dc.contributor.inventorTsang, SY
 
dc.date.accessioned2010-10-31T14:07:18Z
 
patents.date.application2006-08-02
 
dc.date.available2010-10-31T14:07:18Z
 
patents.date.granted2011-08-23
 
dc.date.issued2010
 
patents.date.priority2005-08-08 CN20051089965
 
patents.date.priority2006-08-02 PCT/CN2006001940
 
dc.description.abstractThe present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 105% higher than that of parent D-amino acid oxidase. The method has no need of addition of hydrogen peroxide, [beta]-lactamase inhibitor, catalase inhibitor, catalase and the like commonly used in the prior art. The productivity of the method can reach more than 93%. Thus, the method is simple, low in cost and high in productivity.
 
patents.description.assigneeBIORIGHT WORLDWIDE COMPANY LTD [GB]
 
patents.description.ccUS
 
patents.description.countryUnited States of America
 
patents.description.kindB2
 
dc.description.naturepublished_or_final_version
 
patents.identifier.applicationUS 11/990115
 
dc.identifier.citationUS Patent US 8003358. Washington, DC: US Patent and Trademark Office (USPTO), 2011 [How to Cite?]
 
patents.identifier.grantedUS 8003358
 
dc.identifier.hkuros175329
 
dc.identifier.urihttp://hdl.handle.net/10722/128140
 
dc.languageeng
 
patents.relation.familyCN 1912130 (A) 2007-02-14
 
patents.relation.familyEP 1925663 (A1) 2008-05-28
 
patents.relation.familyUS 2010112633 (A1) 2010-05-06
 
patents.relation.familyWO 2007016861 (A1) 2007-02-15
 
dc.relation.referencesUS 7517677 (B2) 2009-04-14
 
dc.relation.referencesUS 2008009052 (A1) 2008-01-10
 
dc.relation.referencesCN 1104255 (A) 1995-06-28
 
dc.relation.referencesCN 1065278 (C) 2001-05-02
 
dc.relation.referencesCN 1301813 (A) 2001-07-04
 
dc.relation.referencesCN 1371999 (A) 2002-10-02
 
dc.relation.referencesCN 1151261 (C) 2004-05-26
 
dc.relation.referencesCN 1428424 (A) 2003-07-09
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents
 
dc.titleTwo-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid
 
dc.typePatent
 
patents.typePatent_granted
 
<?xml encoding="utf-8" version="1.0"?>
<item><date.accessioned>2010-10-31T14:07:18Z</date.accessioned>
<date.available>2010-10-31T14:07:18Z</date.available>
<date.issued>2010</date.issued>
<identifier.citation>US Patent US 8003358. Washington, DC: US Patent and Trademark Office (USPTO), 2011</identifier.citation>
<identifier.uri>http://hdl.handle.net/10722/128140</identifier.uri>
<description.abstract>The present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 105% higher than that of parent D-amino acid oxidase. The method has no need of addition of hydrogen peroxide, [beta]-lactamase inhibitor, catalase inhibitor, catalase and the like commonly used in the prior art. The productivity of the method can reach more than 93%. Thus, the method is simple, low in cost and high in productivity.</description.abstract>
<language>eng</language>
<rights>Creative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents</rights>
<title>Two-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid</title>
<type>Patent</type>
<description.nature>published_or_final_version</description.nature>
<identifier.hkuros>175329</identifier.hkuros>
<contributor.inventor>Wang, J</contributor.inventor>
<contributor.inventor>Tsang, WK</contributor.inventor>
<contributor.inventor>Yap, HK</contributor.inventor>
<contributor.inventor>Chen, JM</contributor.inventor>
<contributor.inventor>Siu, YL</contributor.inventor>
<contributor.inventor>Tsang, SY</contributor.inventor>
<relation.references>US 7517677 (B2)  2009-04-14</relation.references>
<relation.references>US 2008009052 (A1)  2008-01-10</relation.references>
<relation.references>CN 1104255 (A)  1995-06-28</relation.references>
<relation.references>CN 1065278 (C)  2001-05-02</relation.references>
<relation.references>CN 1301813 (A)  2001-07-04</relation.references>
<relation.references>CN 1371999 (A)  2002-10-02</relation.references>
<relation.references>CN 1151261 (C)  2004-05-26</relation.references>
<relation.references>CN 1428424 (A)  2003-07-09</relation.references>
<patents.identifier.application>US 11/990115</patents.identifier.application>
<patents.identifier.granted>US 8003358</patents.identifier.granted>
<patents.description.assignee>BIORIGHT WORLDWIDE COMPANY LTD [GB]</patents.description.assignee>
<patents.description.country>United States of America</patents.description.country>
<patents.date.granted>2011-08-23</patents.date.granted>
<patents.date.application>2006-08-02</patents.date.application>
<patents.date.priority>2005-08-08 CN20051089965</patents.date.priority>
<patents.date.priority>2006-08-02 PCT/CN2006001940</patents.date.priority>
<patents.description.cc>US</patents.description.cc>
<patents.relation.family>CN 1912130 (A)  2007-02-14</patents.relation.family>
<patents.relation.family>EP 1925663 (A1)  2008-05-28</patents.relation.family>
<patents.relation.family>US 2010112633 (A1)  2010-05-06</patents.relation.family>
<patents.relation.family>WO 2007016861 (A1)  2007-02-15</patents.relation.family>
<patents.description.kind>B2</patents.description.kind>
<patents.type>Patent_granted</patents.type>
<bitstream.url>http://hub.hku.hk/bitstream/10722/128140/1/US8003358B2.pdf</bitstream.url>
</item>