Granted Patent: Two-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid

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Patent History
  • Application
    US 11/990115
    2006-08-02
  • Granted
    US 8003358
    2011-08-23
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TitleTwo-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid
Granted PatentUS 8003358
Granted Date2011-08-23
Priority Date2005-08-08 CN20051089965
2006-08-02 PCT/CN2006001940
InventorsWang, J
Tsang, WK
Yap, HK
Chen, JM
Siu, YL
Tsang, SY
Issue Date2010
CitationUS Patent US 8003358. Washington, DC: US Patent and Trademark Office (USPTO), 2011 [How to Cite?]
AbstractThe present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 105% higher than that of parent D-amino acid oxidase. The method has no need of addition of hydrogen peroxide, [beta]-lactamase inhibitor, catalase inhibitor, catalase and the like commonly used in the prior art. The productivity of the method can reach more than 93%. Thus, the method is simple, low in cost and high in productivity.
ReferencesUS 7517677 (B2) 2009-04-14

US 2008009052 (A1) 2008-01-10

CN 1104255 (A) 1995-06-28

CN 1065278 (C) 2001-05-02

CN 1301813 (A) 2001-07-04

CN 1371999 (A) 2002-10-02

CN 1151261 (C) 2004-05-26

CN 1428424 (A) 2003-07-09
DC Field
Value
dc.contributor.inventorWang, J
dc.contributor.inventorTsang, WK
dc.contributor.inventorYap, HK
dc.contributor.inventorChen, JM
dc.contributor.inventorSiu, YL
dc.contributor.inventorTsang, SY
dc.date.accessioned2010-10-31T14:07:18Z
patents.date.application2006-08-02
dc.date.available2010-10-31T14:07:18Z
patents.date.granted2011-08-23
dc.date.issued2010
patents.date.priority2005-08-08 CN20051089965
patents.date.priority2006-08-02 PCT/CN2006001940
dc.description.abstractThe present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 105% higher than that of parent D-amino acid oxidase. The method has no need of addition of hydrogen peroxide, [beta]-lactamase inhibitor, catalase inhibitor, catalase and the like commonly used in the prior art. The productivity of the method can reach more than 93%. Thus, the method is simple, low in cost and high in productivity.
patents.description.assigneeBIORIGHT WORLDWIDE COMPANY LTD [GB]
patents.description.ccUS
patents.description.countryUnited States of America
patents.description.kindB2
patents.identifier.applicationUS 11/990115
dc.identifier.citationUS Patent US 8003358. Washington, DC: US Patent and Trademark Office (USPTO), 2011 [How to Cite?]
patents.identifier.grantedUS 8003358
dc.identifier.hkuros175329
dc.identifier.urihttp://hdl.handle.net/10722/128140
dc.languageeng
patents.relation.familyCN 1912130 (A) 2007-02-14
patents.relation.familyEP 1925663 (A1) 2008-05-28
patents.relation.familyUS 2010112633 (A1) 2010-05-06
patents.relation.familyWO 2007016861 (A1) 2007-02-15
dc.relation.referencesUS 7517677 (B2) 2009-04-14
dc.relation.referencesUS 2008009052 (A1) 2008-01-10
dc.relation.referencesCN 1104255 (A) 1995-06-28
dc.relation.referencesCN 1065278 (C) 2001-05-02
dc.relation.referencesCN 1301813 (A) 2001-07-04
dc.relation.referencesCN 1371999 (A) 2002-10-02
dc.relation.referencesCN 1151261 (C) 2004-05-26
dc.relation.referencesCN 1428424 (A) 2003-07-09
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents
dc.titleTwo-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid
dc.typePatent
patents.typePatent_granted