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  Patent History
  • Application
    US 11/990115 2006-08-02
  • Granted
    US 8003358 2011-08-23
  Patent Family
Supplementary

granted patent: Two-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid

TitleTwo-Step Enzyme Method for Preparing 7-Aminocephalosporanic Acid
Granted PatentUS 8003358
Granted Date2011-08-23
Priority Date2005-08-08 CN20051089965
2006-08-02 PCT/CN2006001940
Inventors
Wang, JTsang, WKYap, HKChen, JMSiu, YLTsang, SY
Issue Date2010
Citation
US Patent US 8003358. Washington, DC: US Patent and Trademark Office (USPTO), 2011 How to Cite?
AbstractThe present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 105% higher than that of parent D-amino acid oxidase. The method has no need of addition of hydrogen peroxide, [beta]-lactamase inhibitor, catalase inhibitor, catalase and the like commonly used in the prior art. The productivity of the method can reach more than 93%. Thus, the method is simple, low in cost and high in productivity.
Persistent Identifierhttp://hdl.handle.net/10722/128140
References

 

DC FieldValueLanguage
dc.date.accessioned2010-10-31T14:07:18Z-
dc.date.available2010-10-31T14:07:18Z-
dc.date.issued2010en_HK
dc.identifier.citationUS Patent US 8003358. Washington, DC: US Patent and Trademark Office (USPTO), 2011en_HK
dc.identifier.urihttp://hdl.handle.net/10722/128140-
dc.description.abstractThe present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 105% higher than that of parent D-amino acid oxidase. The method has no need of addition of hydrogen peroxide, [beta]-lactamase inhibitor, catalase inhibitor, catalase and the like commonly used in the prior art. The productivity of the method can reach more than 93%. Thus, the method is simple, low in cost and high in productivity.en_HK
dc.languageengen_HK
dc.titleTwo-Step Enzyme Method for Preparing 7-Aminocephalosporanic Aciden_HK
dc.typePatenten_HK
dc.identifier.emailTsang, WK: pwktsang@hku.hken_HK
dc.identifier.emailTsang, WK: pwktsang@hku.hken_HK
dc.identifier.emailTsang, WK: pwktsang@hku.hken_HK
dc.identifier.authorityTsang, WK=rp01388en_HK
dc.identifier.authorityTsang, WK=rp01388en_HK
dc.identifier.authorityTsang, WK=rp01388en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros175329en_HK
dc.contributor.inventorWang, Jen_HK
dc.contributor.inventorTsang, WKen_HK
dc.contributor.inventorYap, HKen_HK
dc.contributor.inventorChen, JMen_HK
dc.contributor.inventorSiu, YLen_HK
dc.contributor.inventorTsang, SYen_HK
patents.identifier.applicationUS 11/990115en_HK
patents.identifier.grantedUS 8003358en_HK
patents.description.assigneeBIORIGHT WORLDWIDE COMPANY LTD [GB]en_HK
patents.description.countryUnited States of Americaen_HK
patents.date.granted2011-08-23en_HK
dc.relation.referencesUS 7517677 (B2) 2009-04-14en_HK
dc.relation.referencesUS 2008009052 (A1) 2008-01-10en_HK
dc.relation.referencesCN 1104255 (A) 1995-06-28en_HK
dc.relation.referencesCN 1065278 (C) 2001-05-02en_HK
dc.relation.referencesCN 1301813 (A) 2001-07-04en_HK
dc.relation.referencesCN 1371999 (A) 2002-10-02en_HK
dc.relation.referencesCN 1151261 (C) 2004-05-26en_HK
dc.relation.referencesCN 1428424 (A) 2003-07-09en_HK
patents.date.application2006-08-02en_HK
patents.date.priority2005-08-08 CN20051089965en_HK
patents.date.priority2006-08-02 PCT/CN2006001940en_HK
patents.description.ccUSen_HK
patents.relation.familyCN 1912130 (A) 2007-02-14en_HK
patents.relation.familyEP 1925663 (A1) 2008-05-28en_HK
patents.relation.familyUS 2010112633 (A1) 2010-05-06en_HK
patents.relation.familyWO 2007016861 (A1) 2007-02-15en_HK
patents.description.kindB2en_HK
patents.typePatent_granteden_HK

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