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Article: Lutein protects RGC-5 cells against hypoxia and oxidative stress

TitleLutein protects RGC-5 cells against hypoxia and oxidative stress
Authors
KeywordsAntioxidants
Carotenoids
Cobalt chloride
Hydrogen peroxide
Ischemia
Issue Date2010
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal Of Molecular Sciences, 2010, v. 11 n. 5, p. 2109-2117 How to Cite?
AbstractRetinal ischemia and oxidative stress lead to neuronal death in many ocular pathologies. Recently, we found that lutein, an oxy-carotenoid, protected the inner retina from ischemia/reperfusion injury. However, it is uncertain whether lutein directly protects retinal ganglion cells (RGCs). Here, an in vitro model of hypoxia and oxidative stress was used to further investigate the neuroprotective role of lutein in RGCs. Cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) were added to a transformed RGC cell line, RGC-5, to induce chemical hypoxia and oxidative stress, respectively. Either lutein or vehicle was added to cultured cells. A higher cell count was observed in the lutein-treated cells compared with the vehicle-treated cells. Our data from this in vitro model revealed that lutein might protect RGC-5 cells from damage when exposed to either CoCl2-induced chemical hypoxia or H2O2-induced oxidative stress. These results suggest that lutein may play a role as a neuroprotectant. © 2010 by the authors.
Persistent Identifierhttp://hdl.handle.net/10722/127675
ISSN
2015 Impact Factor: 3.257
2015 SCImago Journal Rankings: 1.160
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
University Development Fund
University of Hong Kong
Funding Information:

This study was supported by the University Development Fund and the Small Project Funding (Suk-Yee Li) from The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorLi, SYen_HK
dc.contributor.authorLo, ACYen_HK
dc.date.accessioned2010-10-31T13:39:31Z-
dc.date.available2010-10-31T13:39:31Z-
dc.date.issued2010en_HK
dc.identifier.citationInternational Journal Of Molecular Sciences, 2010, v. 11 n. 5, p. 2109-2117en_HK
dc.identifier.issn1422-0067en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127675-
dc.description.abstractRetinal ischemia and oxidative stress lead to neuronal death in many ocular pathologies. Recently, we found that lutein, an oxy-carotenoid, protected the inner retina from ischemia/reperfusion injury. However, it is uncertain whether lutein directly protects retinal ganglion cells (RGCs). Here, an in vitro model of hypoxia and oxidative stress was used to further investigate the neuroprotective role of lutein in RGCs. Cobalt chloride (CoCl2) and hydrogen peroxide (H2O2) were added to a transformed RGC cell line, RGC-5, to induce chemical hypoxia and oxidative stress, respectively. Either lutein or vehicle was added to cultured cells. A higher cell count was observed in the lutein-treated cells compared with the vehicle-treated cells. Our data from this in vitro model revealed that lutein might protect RGC-5 cells from damage when exposed to either CoCl2-induced chemical hypoxia or H2O2-induced oxidative stress. These results suggest that lutein may play a role as a neuroprotectant. © 2010 by the authors.en_HK
dc.languageengen_HK
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijmsen_HK
dc.relation.ispartofInternational Journal of Molecular Sciencesen_HK
dc.subjectAntioxidantsen_HK
dc.subjectCarotenoidsen_HK
dc.subjectCobalt chlorideen_HK
dc.subjectHydrogen peroxideen_HK
dc.subjectIschemiaen_HK
dc.titleLutein protects RGC-5 cells against hypoxia and oxidative stressen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1422-0067&volume=11&spage=2109&epage=2117&date=2010&atitle=Lutein+Protects+RGC-5+Cells+Against+Hypoxia+and+Oxidative+Stress-
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_HK
dc.identifier.authorityLo, ACY=rp00425en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms11052109en_HK
dc.identifier.pmid20559505-
dc.identifier.pmcidPMC2885097-
dc.identifier.scopuseid_2-s2.0-77953394914en_HK
dc.identifier.hkuros181379en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953394914&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue5en_HK
dc.identifier.spage2109en_HK
dc.identifier.epage2117en_HK
dc.identifier.isiWOS:000278105300011-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLi, SY=24329630700en_HK
dc.identifier.scopusauthoridLo, ACY=7102780640en_HK

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