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Article: F4H5: A novel substance for the removal of silicone oil from intraocular lenses

TitleF4H5: A novel substance for the removal of silicone oil from intraocular lenses
Authors
Issue Date2010
PublisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/
Citation
British Journal Of Ophthalmology, 2010, v. 94 n. 3, p. 364-367 How to Cite?
AbstractAim: Adherent silicone oil on intraocular lenses (IOLs) following retinal detachment surgery induces large and irregular refractive errors and multiple images, and gives rise to glare, distorted and often poor vision. Its removal remains challenging, often requiring mechanical wiping or explantation. F 4H5 is a new semifluorinated alkane into which silicone oil is readily soluble. The aim is to establish the effectiveness of F4H5 in removing silicone oil from three different types of IOL in vitro. Method: Silicone lenses (Tecnis ZM900, Advanced Medical Optics, Inc.), hydrophobic acrylic lenses (MA60, Alcon Laboratories, Inc.) and PMMA lenses (Ocular Vision, Inc) were first immersed in phosphate-buffered saline, second in silicone oil, then in F4H5 (Fluoron GmbH) for 10 min and lastly vigorously agitated in F4H5 for 1 min. They were weighed at each stage using scales accurate to 0.0001 g to measure the weight of the adherent oil. Dynamic contact angle (DCA) analysis was used to assess their surface properties. Results: Immersion in F4H5 alone removed 96.1% (±1.23) by weight of silicone oil from the hydrophobic acrylic lenses, 91.4% (±1.58) from the silicone and 95.6% (±1.44) from the PMMA IOLs. Immersion combined with 1 min of agitation increased the removal to 98.8% (±0.46) from the acrylic IOLs, to 93.7% (±0.48) from the silicone IOLs and to 100% (within ±0.0001 g) from every PMMA IOL. After treatment with F4H5, all IOL were optically clear. DCA hysteresis curves remained permanently altered. All measurements were highly reproducible. Conclusion: F4H5 was highly effective at removing the bulk of the silicone oil from all three groups of IOL. The DCA measurements suggested that their surface properties were permanently modified.
Persistent Identifierhttp://hdl.handle.net/10722/127674
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.873
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorStappler, Ten_HK
dc.contributor.authorWilliams, Ren_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2010-10-31T13:39:28Z-
dc.date.available2010-10-31T13:39:28Z-
dc.date.issued2010en_HK
dc.identifier.citationBritish Journal Of Ophthalmology, 2010, v. 94 n. 3, p. 364-367en_HK
dc.identifier.issn0007-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127674-
dc.description.abstractAim: Adherent silicone oil on intraocular lenses (IOLs) following retinal detachment surgery induces large and irregular refractive errors and multiple images, and gives rise to glare, distorted and often poor vision. Its removal remains challenging, often requiring mechanical wiping or explantation. F 4H5 is a new semifluorinated alkane into which silicone oil is readily soluble. The aim is to establish the effectiveness of F4H5 in removing silicone oil from three different types of IOL in vitro. Method: Silicone lenses (Tecnis ZM900, Advanced Medical Optics, Inc.), hydrophobic acrylic lenses (MA60, Alcon Laboratories, Inc.) and PMMA lenses (Ocular Vision, Inc) were first immersed in phosphate-buffered saline, second in silicone oil, then in F4H5 (Fluoron GmbH) for 10 min and lastly vigorously agitated in F4H5 for 1 min. They were weighed at each stage using scales accurate to 0.0001 g to measure the weight of the adherent oil. Dynamic contact angle (DCA) analysis was used to assess their surface properties. Results: Immersion in F4H5 alone removed 96.1% (±1.23) by weight of silicone oil from the hydrophobic acrylic lenses, 91.4% (±1.58) from the silicone and 95.6% (±1.44) from the PMMA IOLs. Immersion combined with 1 min of agitation increased the removal to 98.8% (±0.46) from the acrylic IOLs, to 93.7% (±0.48) from the silicone IOLs and to 100% (within ±0.0001 g) from every PMMA IOL. After treatment with F4H5, all IOL were optically clear. DCA hysteresis curves remained permanently altered. All measurements were highly reproducible. Conclusion: F4H5 was highly effective at removing the bulk of the silicone oil from all three groups of IOL. The DCA measurements suggested that their surface properties were permanently modified.en_HK
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://bjo.bmjjournals.com/en_HK
dc.relation.ispartofBritish Journal of Ophthalmologyen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdhesiveness - drug effects-
dc.subject.meshFluorocarbons - pharmacology-
dc.subject.meshLenses, Intraocular-
dc.subject.meshSilicone Oils-
dc.subject.meshSolvents - pharmacology-
dc.titleF4H5: A novel substance for the removal of silicone oil from intraocular lensesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-1161&volume=94&issue=3&spage=364&epage=367&date=2010&atitle=F4H5:+a+novel+substance+for+the+removal+of+silicone+oil+from+intraocular+lenses-
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/bjo.2009.161489en_HK
dc.identifier.pmid19828515-
dc.identifier.scopuseid_2-s2.0-77949522104en_HK
dc.identifier.hkuros182894en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949522104&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume94en_HK
dc.identifier.issue3en_HK
dc.identifier.spage364en_HK
dc.identifier.epage367en_HK
dc.identifier.isiWOS:000275346200023-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridStappler, T=8563727800en_HK
dc.identifier.scopusauthoridWilliams, R=10042153900en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK

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