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Article: Increasing the extensional viscosity of silicone oil reduces the tendency for emulsification

TitleIncreasing the extensional viscosity of silicone oil reduces the tendency for emulsification
Authors
KeywordsEmulsification
Extensional viscosity
Newtonian fluid
Oil droplets
Poly(dimethyl siloxane)
Retinal detachment
Shear viscosity
Silicone oil
Tamponade agents
Viscoelastic fluid
Issue Date2010
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.retinajournal.com
Citation
Retina, 2010, v. 30 n. 2, p. 300-304 How to Cite?
AbstractPurpose: The purpose was to study the emulsification of silicone oil tamponade agents that cause clinical complications. This study aimed to increase the emulsification resistance of silicone oil 1,000 to be at least as resistant as silicone oil 5,000 while maintaining the shear viscosity <5,000 mPa/s to aid injection and removal. Methods: High-molecular-weight (423 kDa) poly(dimethyl siloxane) was added to silicone oil 1,000 at 5% and 10% w/w concentration. The shear and extensional viscosity of 1,000 and 5,000, a 50: 50 mixture of 1,000 and 5,000 and 5% and 10% w/w additive blends, respectively, of silicone oil were measured using capillary breakup extensional, rotational shear, and capillary extrusion rheometry. In vitro emulsification was assessed qualitatively after agitation using Pluronic F68 or a protein solution as the emulsion stabilizer. Results: The addition of high-molecular-weight polymer increased the extensional viscosity of the blends at high strain rates to levels equal to or greater than silicone oil 5,000. In all cases, the shear viscosity of the blends was lower than that of silicone oil 5,000. The additive blends were qualitatively as emulsification-resistant as silicone oil 5,000. Conclusion: The addition of low concentrations of very-high-molecular-weight polymers of the same chemistry as the bulk oil has the potential to increase the emulsification resistance of the tamponade agents while maintaining ease of injection and removal. Copyright © by Ophthalmic Communications Society, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/127666
ISSN
2015 Impact Factor: 3.039
2015 SCImago Journal Rankings: 1.912
ISI Accession Number ID
Funding AgencyGrant Number
Engineering and Physical Sciences Research Council, UKEP/C546679/01
Fluoron GmbH
Funding Information:

Supported by Engineering and Physical Sciences Research Council, UK (EP/C546679/01) and Fluoron GmbH.

References

 

DC FieldValueLanguage
dc.contributor.authorWilliams, RLen_HK
dc.contributor.authorDay, Men_HK
dc.contributor.authorGarvey, MJen_HK
dc.contributor.authorEnglish, Ren_HK
dc.contributor.authorWong, Den_HK
dc.date.accessioned2010-10-31T13:39:00Z-
dc.date.available2010-10-31T13:39:00Z-
dc.date.issued2010en_HK
dc.identifier.citationRetina, 2010, v. 30 n. 2, p. 300-304en_HK
dc.identifier.issn0275-004Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/127666-
dc.description.abstractPurpose: The purpose was to study the emulsification of silicone oil tamponade agents that cause clinical complications. This study aimed to increase the emulsification resistance of silicone oil 1,000 to be at least as resistant as silicone oil 5,000 while maintaining the shear viscosity <5,000 mPa/s to aid injection and removal. Methods: High-molecular-weight (423 kDa) poly(dimethyl siloxane) was added to silicone oil 1,000 at 5% and 10% w/w concentration. The shear and extensional viscosity of 1,000 and 5,000, a 50: 50 mixture of 1,000 and 5,000 and 5% and 10% w/w additive blends, respectively, of silicone oil were measured using capillary breakup extensional, rotational shear, and capillary extrusion rheometry. In vitro emulsification was assessed qualitatively after agitation using Pluronic F68 or a protein solution as the emulsion stabilizer. Results: The addition of high-molecular-weight polymer increased the extensional viscosity of the blends at high strain rates to levels equal to or greater than silicone oil 5,000. In all cases, the shear viscosity of the blends was lower than that of silicone oil 5,000. The additive blends were qualitatively as emulsification-resistant as silicone oil 5,000. Conclusion: The addition of low concentrations of very-high-molecular-weight polymers of the same chemistry as the bulk oil has the potential to increase the emulsification resistance of the tamponade agents while maintaining ease of injection and removal. Copyright © by Ophthalmic Communications Society, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.retinajournal.comen_HK
dc.relation.ispartofRetinaen_HK
dc.subjectEmulsificationen_HK
dc.subjectExtensional viscosityen_HK
dc.subjectNewtonian fluiden_HK
dc.subjectOil dropletsen_HK
dc.subjectPoly(dimethyl siloxane)en_HK
dc.subjectRetinal detachmenten_HK
dc.subjectShear viscosityen_HK
dc.subjectSilicone oilen_HK
dc.subjectTamponade agentsen_HK
dc.subjectViscoelastic fluiden_HK
dc.subject.meshDimethylpolysiloxanes - chemistry-
dc.subject.meshEmulsions-
dc.subject.meshSilicone Oils - chemistry-
dc.subject.meshViscosity-
dc.titleIncreasing the extensional viscosity of silicone oil reduces the tendency for emulsificationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0275-004X&volume=30&issue=2&spage=300&epage=304&date=2010&atitle=Increasing+the+extensional+viscosity+of+silicone+oil+reduces+the+tendency+for+emulsification-
dc.identifier.emailWong, D: shdwong@hku.hken_HK
dc.identifier.authorityWong, D=rp00516en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/IAE.0b013e3181babe0cen_HK
dc.identifier.pmid19920769en_HK
dc.identifier.scopuseid_2-s2.0-76749134770en_HK
dc.identifier.hkuros182897en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76749134770&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue2en_HK
dc.identifier.spage300en_HK
dc.identifier.epage304en_HK
dc.identifier.isiWOS:000278547400015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWilliams, RL=10042153900en_HK
dc.identifier.scopusauthoridDay, M=24767294300en_HK
dc.identifier.scopusauthoridGarvey, MJ=7102440425en_HK
dc.identifier.scopusauthoridEnglish, R=7102997114en_HK
dc.identifier.scopusauthoridWong, D=7401536078en_HK

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