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Article: Beyond water channel: Aquaporin-4 in adult neurogenesis

TitleBeyond water channel: Aquaporin-4 in adult neurogenesis
Authors
KeywordsAdult neurogenesis
Aquaporin-4
Cell differentiation
Cell proliferation
Issue Date2010
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuint
Citation
Neurochemistry International, 2010, v. 56 n. 5, p. 651-654 How to Cite?
AbstractAquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regulating the multiple steps of adult neurogenesis. In this mini-review, we discuss the recent findings that reveal a specific functional role of AQP4 in regulating the adult neurogenesis, including proliferation of neural progenitors/neural stem cells, fate specification and differentiation, neuronal migration, and the potential mechanisms. Further studies on the regulation of AQP4 in promoting neurogenesis will lead to better understanding of the signaling mechanisms of adult neurogenesis and potentially provide an opportunity to develop AQP4 as new drug target for neurogenesis. © 2010 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/127598
ISSN
2015 Impact Factor: 3.385
2015 SCImago Journal Rankings: 1.345
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200807176043
RGC774408M
Second Affiliated Hospital of Wenzhou Medical College2009
Zhejiang Province Administration of TCM2006C100
Funding Information:

This work is supported by the Small Project Funding of University of Hong Kong (200807176043, S.J.-g.) and RGC GRF Grant (774408M, S.J.-g.), and Research and development fund of the Second Affiliated Hospital of Wenzhou Medical College (2009, Z.G.-q.) and Zhejiang Province Administration of TCM Grant (2006C100, Z.G.-q.).

References

 

DC FieldValueLanguage
dc.contributor.authorZheng, GQen_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorGu, Yen_HK
dc.contributor.authorChen, XMen_HK
dc.contributor.authorZhou, Yen_HK
dc.contributor.authorZhao, SZen_HK
dc.contributor.authorShen, Jen_HK
dc.date.accessioned2010-10-31T13:34:49Z-
dc.date.available2010-10-31T13:34:49Z-
dc.date.issued2010en_HK
dc.identifier.citationNeurochemistry International, 2010, v. 56 n. 5, p. 651-654en_HK
dc.identifier.issn0197-0186en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127598-
dc.description.abstractAquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regulating the multiple steps of adult neurogenesis. In this mini-review, we discuss the recent findings that reveal a specific functional role of AQP4 in regulating the adult neurogenesis, including proliferation of neural progenitors/neural stem cells, fate specification and differentiation, neuronal migration, and the potential mechanisms. Further studies on the regulation of AQP4 in promoting neurogenesis will lead to better understanding of the signaling mechanisms of adult neurogenesis and potentially provide an opportunity to develop AQP4 as new drug target for neurogenesis. © 2010 Elsevier Ltd.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuinten_HK
dc.relation.ispartofNeurochemistry Internationalen_HK
dc.subjectAdult neurogenesisen_HK
dc.subjectAquaporin-4en_HK
dc.subjectCell differentiationen_HK
dc.subjectCell proliferationen_HK
dc.titleBeyond water channel: Aquaporin-4 in adult neurogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0197-0186&volume=56&issue=5&spage=651&epage=654&date=2010&atitle=Beyond+Water+Channel:+Aquaporin-4+in+Adult+Neurogenesisen_HK
dc.identifier.emailShen, J: shenjg@hku.hken_HK
dc.identifier.authorityShen, J=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neuint.2010.01.014en_HK
dc.identifier.pmid20138100en_HK
dc.identifier.scopuseid_2-s2.0-77949568633en_HK
dc.identifier.hkuros175945en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949568633&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume56en_HK
dc.identifier.issue5en_HK
dc.identifier.spage651en_HK
dc.identifier.epage654en_HK
dc.identifier.isiWOS:000277228700001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZheng, GQ=23969618100en_HK
dc.identifier.scopusauthoridLi, Y=26643036800en_HK
dc.identifier.scopusauthoridGu, Y=37014467100en_HK
dc.identifier.scopusauthoridChen, XM=36670920600en_HK
dc.identifier.scopusauthoridZhou, Y=7405362604en_HK
dc.identifier.scopusauthoridZhao, SZ=7403577884en_HK
dc.identifier.scopusauthoridShen, J=7404929947en_HK
dc.identifier.citeulike6724526-

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