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Article: Psychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China
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TitlePsychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China
 
AuthorsWang, HH1
Zhang, ZJ3
Tan, QR1
Yin, H1
Chen, YC1
Wang, HN1
Zhang, RG1
Wang, ZZ1
Guo, L1
Tang, LH1
Li, LJ2
 
KeywordsCoalmining disaster
Hypothalamic-pituitary-adrenal (HPA) axis
Magnetic resonance imaging
Posttraumatic stress disorder (PTSD)
 
Issue Date2010
 
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires
 
CitationJournal Of Psychiatric Research, 2010, v. 44 n. 6, p. 385-392 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jpsychires.2009.10.001
 
AbstractOn July 29, 2007, a severe coalmine-flooded disaster occurred in central China and 69 miners were trapped in an about 1400. m underground coal pit. Fortunately, all of them were rescued after 75. h of the ordeal. At 3 and 6. months after the disaster, psychopathological profiles, plasma levels of cortisol and adrenocorticotropic hormone (ACTH) were evaluated in 48 survivors for posttraumatic stress disorder (PTSD) and comorbid symptoms. Magnetic resonance imaging (MRI) study was performed at 6. months. The prevalence of PTSD was 35.4% (17/48) at 3. months and 31.3% (15/48) at 6. months post-disaster, with high rates of comorbid symptoms. Risk factors for PTSD included previous traumatic experience, less than 5. years of being a miner, in an extremely exhausted or sick during the disaster, poor interpersonal relationship and poor sleep quality experienced before the disaster. Mean plasma cortisol levels at 6. months, but not at 3. months, were significantly higher in PTSD-positive subjects than the negative, and positively correlated with the severity of several comorbid symptoms. Either whole or regional brain volumes of PTSD-positive subjects were not significantly different from PTSD-negative subjects, but PTSD subjects had significantly reduced fractional anisotropy values in the right posterior cingulum and bilateral hippocampal body compared to subjects without PTSD. These results suggest that traumatic exposure in severe coalmining disasters results in considerable psychological consequences, with highly prevalent PTSD and comorbid symptoms, which are associated with previous traumatic experience, shorter-length underground services, and poor interpersonal relationships and sleep quality experienced before the disaster. Baseline cortisol level may be a useful biological predictor for different phases of the development of PTSD. The aberrant connectivity of the hippocampus and the cingulum may represent an early pathological response to trauma exposure. © 2009 Elsevier Ltd.
 
ISSN0022-3956
2013 Impact Factor: 4.092
2013 SCImago Journal Rankings: 2.165
 
DOIhttp://dx.doi.org/10.1016/j.jpsychires.2009.10.001
 
ISI Accession Number IDWOS:000277820300007
Funding AgencyGrant Number
11th Five-Year Medical Science Foundations06G096
National key Technology R&D Program in the 11th Five-year Plan of China2007BAI17B02
HKU Basic and Applied Research Funds200802160012
200711159030
200611159027
Funding Information:

This study was supported by the 11th Five-Year Medical Science Foundations (06G096, QRT), National key Technology R&D Program in the 11th Five-year Plan of China (2007BAI17B02, LJL), and HKU Basic and Applied Research Funds (200802160012, 200711159030, and 200611159027, ZJZ). All funding bodies had no role in study design, data collection and processing, the preparation and submission of the manuscript.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWang, HH
 
dc.contributor.authorZhang, ZJ
 
dc.contributor.authorTan, QR
 
dc.contributor.authorYin, H
 
dc.contributor.authorChen, YC
 
dc.contributor.authorWang, HN
 
dc.contributor.authorZhang, RG
 
dc.contributor.authorWang, ZZ
 
dc.contributor.authorGuo, L
 
dc.contributor.authorTang, LH
 
dc.contributor.authorLi, LJ
 
dc.date.accessioned2010-10-31T13:34:29Z
 
dc.date.available2010-10-31T13:34:29Z
 
dc.date.issued2010
 
dc.description.abstractOn July 29, 2007, a severe coalmine-flooded disaster occurred in central China and 69 miners were trapped in an about 1400. m underground coal pit. Fortunately, all of them were rescued after 75. h of the ordeal. At 3 and 6. months after the disaster, psychopathological profiles, plasma levels of cortisol and adrenocorticotropic hormone (ACTH) were evaluated in 48 survivors for posttraumatic stress disorder (PTSD) and comorbid symptoms. Magnetic resonance imaging (MRI) study was performed at 6. months. The prevalence of PTSD was 35.4% (17/48) at 3. months and 31.3% (15/48) at 6. months post-disaster, with high rates of comorbid symptoms. Risk factors for PTSD included previous traumatic experience, less than 5. years of being a miner, in an extremely exhausted or sick during the disaster, poor interpersonal relationship and poor sleep quality experienced before the disaster. Mean plasma cortisol levels at 6. months, but not at 3. months, were significantly higher in PTSD-positive subjects than the negative, and positively correlated with the severity of several comorbid symptoms. Either whole or regional brain volumes of PTSD-positive subjects were not significantly different from PTSD-negative subjects, but PTSD subjects had significantly reduced fractional anisotropy values in the right posterior cingulum and bilateral hippocampal body compared to subjects without PTSD. These results suggest that traumatic exposure in severe coalmining disasters results in considerable psychological consequences, with highly prevalent PTSD and comorbid symptoms, which are associated with previous traumatic experience, shorter-length underground services, and poor interpersonal relationships and sleep quality experienced before the disaster. Baseline cortisol level may be a useful biological predictor for different phases of the development of PTSD. The aberrant connectivity of the hippocampus and the cingulum may represent an early pathological response to trauma exposure. © 2009 Elsevier Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Psychiatric Research, 2010, v. 44 n. 6, p. 385-392 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.jpsychires.2009.10.001
 
dc.identifier.citeulike6230305
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.jpsychires.2009.10.001
 
dc.identifier.epage392
 
dc.identifier.hkuros174204
 
dc.identifier.isiWOS:000277820300007
Funding AgencyGrant Number
11th Five-Year Medical Science Foundations06G096
National key Technology R&D Program in the 11th Five-year Plan of China2007BAI17B02
HKU Basic and Applied Research Funds200802160012
200711159030
200611159027
Funding Information:

This study was supported by the 11th Five-Year Medical Science Foundations (06G096, QRT), National key Technology R&D Program in the 11th Five-year Plan of China (2007BAI17B02, LJL), and HKU Basic and Applied Research Funds (200802160012, 200711159030, and 200611159027, ZJZ). All funding bodies had no role in study design, data collection and processing, the preparation and submission of the manuscript.

 
dc.identifier.issn0022-3956
2013 Impact Factor: 4.092
2013 SCImago Journal Rankings: 2.165
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid19896142
 
dc.identifier.scopuseid_2-s2.0-77950942136
 
dc.identifier.spage385
 
dc.identifier.urihttp://hdl.handle.net/10722/127592
 
dc.identifier.volume44
 
dc.languageeng
 
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Psychiatric Research
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshBrain - pathology
 
dc.subject.meshDisasters
 
dc.subject.meshHydrocortisone - blood
 
dc.subject.meshMagnetic Resonance Imaging
 
dc.subject.meshStress Disorders, Post-Traumatic - blood - epidemiology - etiology - pathology - psychology
 
dc.subjectCoalmining disaster
 
dc.subjectHypothalamic-pituitary-adrenal (HPA) axis
 
dc.subjectMagnetic resonance imaging
 
dc.subjectPosttraumatic stress disorder (PTSD)
 
dc.titlePsychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China
 
dc.typeArticle
 
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Author Affiliations
  1. Xijing Hospital
  2. Second Xiangya Hospital of Central-South University
  3. The University of Hong Kong