Article: Psychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China
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- Publisher Website: 10.1016/j.jpsychires.2009.10.001
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- PMID: 19896142
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| Title | Psychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Wang, HH2 Zhang, ZJ3 Tan, QR2 Yin, H2 Chen, YC2 Wang, HN2 Zhang, RG2 Wang, ZZ2 Guo, L2 Tang, LH2 Li, LJ1 | ||||||||
| Keywords | Coalmining disaster Hypothalamic-pituitary-adrenal (HPA) axis Magnetic resonance imaging Posttraumatic stress disorder (PTSD) | ||||||||
| Issue Date | 2010 | ||||||||
| Publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires | ||||||||
| Citation | Journal Of Psychiatric Research, 2010, v. 44 n. 6, p. 385-392 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.jpsychires.2009.10.001 | ||||||||
| Abstract | On July 29, 2007, a severe coalmine-flooded disaster occurred in central China and 69 miners were trapped in an about 1400. m underground coal pit. Fortunately, all of them were rescued after 75. h of the ordeal. At 3 and 6. months after the disaster, psychopathological profiles, plasma levels of cortisol and adrenocorticotropic hormone (ACTH) were evaluated in 48 survivors for posttraumatic stress disorder (PTSD) and comorbid symptoms. Magnetic resonance imaging (MRI) study was performed at 6. months. The prevalence of PTSD was 35.4% (17/48) at 3. months and 31.3% (15/48) at 6. months post-disaster, with high rates of comorbid symptoms. Risk factors for PTSD included previous traumatic experience, less than 5. years of being a miner, in an extremely exhausted or sick during the disaster, poor interpersonal relationship and poor sleep quality experienced before the disaster. Mean plasma cortisol levels at 6. months, but not at 3. months, were significantly higher in PTSD-positive subjects than the negative, and positively correlated with the severity of several comorbid symptoms. Either whole or regional brain volumes of PTSD-positive subjects were not significantly different from PTSD-negative subjects, but PTSD subjects had significantly reduced fractional anisotropy values in the right posterior cingulum and bilateral hippocampal body compared to subjects without PTSD. These results suggest that traumatic exposure in severe coalmining disasters results in considerable psychological consequences, with highly prevalent PTSD and comorbid symptoms, which are associated with previous traumatic experience, shorter-length underground services, and poor interpersonal relationships and sleep quality experienced before the disaster. Baseline cortisol level may be a useful biological predictor for different phases of the development of PTSD. The aberrant connectivity of the hippocampus and the cingulum may represent an early pathological response to trauma exposure. © 2009 Elsevier Ltd. | ||||||||
| ISSN | 0022-3956 2011 Impact Factor: 4.664 2011 SCImago Journal Rankings: 0.220 | ||||||||
| DOI | http://dx.doi.org/10.1016/j.jpsychires.2009.10.001 | ||||||||
| ISI Accession Number ID | WOS:000277820300007
Funding Information: This study was supported by the 11th Five-Year Medical Science Foundations (06G096, QRT), National key Technology R&D Program in the 11th Five-year Plan of China (2007BAI17B02, LJL), and HKU Basic and Applied Research Funds (200802160012, 200711159030, and 200611159027, ZJZ). All funding bodies had no role in study design, data collection and processing, the preparation and submission of the manuscript. | ||||||||
| References | References in Scopus | ||||||||
| Grants | Pharmacokinetic and therapeutic characterization of liguslitide nasal spray (????????) for premenstrual syndromes Behavioral and genomic/proteomic mechanisms of D1 agonistic-D2 antagonistic dual action of stepholidine against negative and cognitive symptoms of schizophrenia Therapeutic effects of ligustilide and mechanisms of its actions against premenstrual dysphoric disorder (PMDD) |
| dc.contributor.author | Wang, HH | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Zhang, ZJ | ||||||||
| dc.contributor.author | Tan, QR | ||||||||
| dc.contributor.author | Yin, H | ||||||||
| dc.contributor.author | Chen, YC | ||||||||
| dc.contributor.author | Wang, HN | ||||||||
| dc.contributor.author | Zhang, RG | ||||||||
| dc.contributor.author | Wang, ZZ | ||||||||
| dc.contributor.author | Guo, L | ||||||||
| dc.contributor.author | Tang, LH | ||||||||
| dc.contributor.author | Li, LJ | ||||||||
| dc.date.accessioned | 2010-10-31T13:34:29Z | ||||||||
| dc.date.available | 2010-10-31T13:34:29Z | ||||||||
| dc.date.issued | 2010 | ||||||||
| dc.description.abstract | On July 29, 2007, a severe coalmine-flooded disaster occurred in central China and 69 miners were trapped in an about 1400. m underground coal pit. Fortunately, all of them were rescued after 75. h of the ordeal. At 3 and 6. months after the disaster, psychopathological profiles, plasma levels of cortisol and adrenocorticotropic hormone (ACTH) were evaluated in 48 survivors for posttraumatic stress disorder (PTSD) and comorbid symptoms. Magnetic resonance imaging (MRI) study was performed at 6. months. The prevalence of PTSD was 35.4% (17/48) at 3. months and 31.3% (15/48) at 6. months post-disaster, with high rates of comorbid symptoms. Risk factors for PTSD included previous traumatic experience, less than 5. years of being a miner, in an extremely exhausted or sick during the disaster, poor interpersonal relationship and poor sleep quality experienced before the disaster. Mean plasma cortisol levels at 6. months, but not at 3. months, were significantly higher in PTSD-positive subjects than the negative, and positively correlated with the severity of several comorbid symptoms. Either whole or regional brain volumes of PTSD-positive subjects were not significantly different from PTSD-negative subjects, but PTSD subjects had significantly reduced fractional anisotropy values in the right posterior cingulum and bilateral hippocampal body compared to subjects without PTSD. These results suggest that traumatic exposure in severe coalmining disasters results in considerable psychological consequences, with highly prevalent PTSD and comorbid symptoms, which are associated with previous traumatic experience, shorter-length underground services, and poor interpersonal relationships and sleep quality experienced before the disaster. Baseline cortisol level may be a useful biological predictor for different phases of the development of PTSD. The aberrant connectivity of the hippocampus and the cingulum may represent an early pathological response to trauma exposure. © 2009 Elsevier Ltd. | ||||||||
| dc.description.grant | Pharmacokinetic and therapeutic characterization of liguslitide nasal spray (????????) for premenstrual syndromes | ||||||||
| dc.description.grant | Behavioral and genomic/proteomic mechanisms of D1 agonistic-D2 antagonistic dual action of stepholidine against negative and cognitive symptoms of schizophrenia | ||||||||
| dc.description.grant | Therapeutic effects of ligustilide and mechanisms of its actions against premenstrual dysphoric disorder (PMDD) | ||||||||
| dc.description.grantcode | 98294 | ||||||||
| dc.description.grantcode | 97919 | ||||||||
| dc.description.grantcode | 96069 | ||||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||||
| dc.identifier.citation | Journal Of Psychiatric Research, 2010, v. 44 n. 6, p. 385-392 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.jpsychires.2009.10.001 | ||||||||
| dc.identifier.citeulike | 6230305 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.jpsychires.2009.10.001 | ||||||||
| dc.identifier.epage | 392 | ||||||||
| dc.identifier.hkuros | 174204 | ||||||||
| dc.identifier.isi | WOS:000277820300007
Funding Information: This study was supported by the 11th Five-Year Medical Science Foundations (06G096, QRT), National key Technology R&D Program in the 11th Five-year Plan of China (2007BAI17B02, LJL), and HKU Basic and Applied Research Funds (200802160012, 200711159030, and 200611159027, ZJZ). All funding bodies had no role in study design, data collection and processing, the preparation and submission of the manuscript. | ||||||||
| dc.identifier.issn | 0022-3956 2011 Impact Factor: 4.664 2011 SCImago Journal Rankings: 0.220 | ||||||||
| dc.identifier.issue | 6 | ||||||||
| dc.identifier.openurl | | ||||||||
| dc.identifier.pmid | 19896142 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-77950942136 | ||||||||
| dc.identifier.spage | 385 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/127592 | ||||||||
| dc.identifier.volume | 44 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires | ||||||||
| dc.publisher.place | United Kingdom | ||||||||
| dc.relation.ispartof | Journal of Psychiatric Research | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.subject.mesh | Brain - pathology | ||||||||
| dc.subject.mesh | Disasters | ||||||||
| dc.subject.mesh | Hydrocortisone - blood | ||||||||
| dc.subject.mesh | Magnetic Resonance Imaging | ||||||||
| dc.subject.mesh | Stress Disorders, Post-Traumatic - blood - epidemiology - etiology - pathology - psychology | ||||||||
| dc.subject | Coalmining disaster | ||||||||
| dc.subject | Hypothalamic-pituitary-adrenal (HPA) axis | ||||||||
| dc.subject | Magnetic resonance imaging | ||||||||
| dc.subject | Posttraumatic stress disorder (PTSD) | ||||||||
| dc.title | Psychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China | ||||||||
| dc.type | Article |
Author Affiliations
- Second Xiangya Hospital of Central-South University
- Xijing Hospital
- The University of Hong Kong