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Article: Psychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China

TitlePsychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in China
Authors
KeywordsCoalmining disaster
Hypothalamic-pituitary-adrenal (HPA) axis
Magnetic resonance imaging
Posttraumatic stress disorder (PTSD)
Issue Date2010
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychires
Citation
Journal Of Psychiatric Research, 2010, v. 44 n. 6, p. 385-392 How to Cite?
Abstract
On July 29, 2007, a severe coalmine-flooded disaster occurred in central China and 69 miners were trapped in an about 1400. m underground coal pit. Fortunately, all of them were rescued after 75. h of the ordeal. At 3 and 6. months after the disaster, psychopathological profiles, plasma levels of cortisol and adrenocorticotropic hormone (ACTH) were evaluated in 48 survivors for posttraumatic stress disorder (PTSD) and comorbid symptoms. Magnetic resonance imaging (MRI) study was performed at 6. months. The prevalence of PTSD was 35.4% (17/48) at 3. months and 31.3% (15/48) at 6. months post-disaster, with high rates of comorbid symptoms. Risk factors for PTSD included previous traumatic experience, less than 5. years of being a miner, in an extremely exhausted or sick during the disaster, poor interpersonal relationship and poor sleep quality experienced before the disaster. Mean plasma cortisol levels at 6. months, but not at 3. months, were significantly higher in PTSD-positive subjects than the negative, and positively correlated with the severity of several comorbid symptoms. Either whole or regional brain volumes of PTSD-positive subjects were not significantly different from PTSD-negative subjects, but PTSD subjects had significantly reduced fractional anisotropy values in the right posterior cingulum and bilateral hippocampal body compared to subjects without PTSD. These results suggest that traumatic exposure in severe coalmining disasters results in considerable psychological consequences, with highly prevalent PTSD and comorbid symptoms, which are associated with previous traumatic experience, shorter-length underground services, and poor interpersonal relationships and sleep quality experienced before the disaster. Baseline cortisol level may be a useful biological predictor for different phases of the development of PTSD. The aberrant connectivity of the hippocampus and the cingulum may represent an early pathological response to trauma exposure. © 2009 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/127592
ISSN
2013 Impact Factor: 4.092
2013 SCImago Journal Rankings: 2.165
ISI Accession Number ID
Funding AgencyGrant Number
11th Five-Year Medical Science Foundations06G096
National key Technology R&D Program in the 11th Five-year Plan of China2007BAI17B02
HKU Basic and Applied Research Funds200802160012
200711159030
200611159027
Funding Information:

This study was supported by the 11th Five-Year Medical Science Foundations (06G096, QRT), National key Technology R&D Program in the 11th Five-year Plan of China (2007BAI17B02, LJL), and HKU Basic and Applied Research Funds (200802160012, 200711159030, and 200611159027, ZJZ). All funding bodies had no role in study design, data collection and processing, the preparation and submission of the manuscript.

References

 

Author Affiliations
  1. Xijing Hospital
  2. Second Xiangya Hospital of Central-South University
  3. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorWang, HHen_HK
dc.contributor.authorZhang, ZJen_HK
dc.contributor.authorTan, QRen_HK
dc.contributor.authorYin, Hen_HK
dc.contributor.authorChen, YCen_HK
dc.contributor.authorWang, HNen_HK
dc.contributor.authorZhang, RGen_HK
dc.contributor.authorWang, ZZen_HK
dc.contributor.authorGuo, Len_HK
dc.contributor.authorTang, LHen_HK
dc.contributor.authorLi, LJen_HK
dc.date.accessioned2010-10-31T13:34:29Z-
dc.date.available2010-10-31T13:34:29Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Psychiatric Research, 2010, v. 44 n. 6, p. 385-392en_HK
dc.identifier.issn0022-3956en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127592-
dc.description.abstractOn July 29, 2007, a severe coalmine-flooded disaster occurred in central China and 69 miners were trapped in an about 1400. m underground coal pit. Fortunately, all of them were rescued after 75. h of the ordeal. At 3 and 6. months after the disaster, psychopathological profiles, plasma levels of cortisol and adrenocorticotropic hormone (ACTH) were evaluated in 48 survivors for posttraumatic stress disorder (PTSD) and comorbid symptoms. Magnetic resonance imaging (MRI) study was performed at 6. months. The prevalence of PTSD was 35.4% (17/48) at 3. months and 31.3% (15/48) at 6. months post-disaster, with high rates of comorbid symptoms. Risk factors for PTSD included previous traumatic experience, less than 5. years of being a miner, in an extremely exhausted or sick during the disaster, poor interpersonal relationship and poor sleep quality experienced before the disaster. Mean plasma cortisol levels at 6. months, but not at 3. months, were significantly higher in PTSD-positive subjects than the negative, and positively correlated with the severity of several comorbid symptoms. Either whole or regional brain volumes of PTSD-positive subjects were not significantly different from PTSD-negative subjects, but PTSD subjects had significantly reduced fractional anisotropy values in the right posterior cingulum and bilateral hippocampal body compared to subjects without PTSD. These results suggest that traumatic exposure in severe coalmining disasters results in considerable psychological consequences, with highly prevalent PTSD and comorbid symptoms, which are associated with previous traumatic experience, shorter-length underground services, and poor interpersonal relationships and sleep quality experienced before the disaster. Baseline cortisol level may be a useful biological predictor for different phases of the development of PTSD. The aberrant connectivity of the hippocampus and the cingulum may represent an early pathological response to trauma exposure. © 2009 Elsevier Ltd.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jpsychiresen_HK
dc.relation.ispartofJournal of Psychiatric Researchen_HK
dc.subjectCoalmining disasteren_HK
dc.subjectHypothalamic-pituitary-adrenal (HPA) axisen_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subjectPosttraumatic stress disorder (PTSD)en_HK
dc.subject.meshBrain - pathology-
dc.subject.meshDisasters-
dc.subject.meshHydrocortisone - blood-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshStress Disorders, Post-Traumatic - blood - epidemiology - etiology - pathology - psychology-
dc.titlePsychopathological, biological, and neuroimaging characterization of posttraumatic stress disorder in survivors of a severe coalmining disaster in Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3956&volume=44&issue=6&spage=385&epage=392&date=2010&atitle=Psychopathological,+biological,+and+neuroimaging+characterization+of+posttraumatic+stress+disorder+in+survivors+of+a+severe+coalmining+disaster+in+Chinaen_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jpsychires.2009.10.001en_HK
dc.identifier.pmid19896142en_HK
dc.identifier.scopuseid_2-s2.0-77950942136en_HK
dc.identifier.hkuros174204en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77950942136&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue6en_HK
dc.identifier.spage385en_HK
dc.identifier.epage392en_HK
dc.identifier.isiWOS:000277820300007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, HH=10144885500en_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK
dc.identifier.scopusauthoridTan, QR=7102120177en_HK
dc.identifier.scopusauthoridYin, H=7403114096en_HK
dc.identifier.scopusauthoridChen, YC=22833345400en_HK
dc.identifier.scopusauthoridWang, HN=35109844400en_HK
dc.identifier.scopusauthoridZhang, RG=7404865068en_HK
dc.identifier.scopusauthoridWang, ZZ=35109815300en_HK
dc.identifier.scopusauthoridGuo, L=55205243200en_HK
dc.identifier.scopusauthoridTang, LH=37102923400en_HK
dc.identifier.scopusauthoridLi, LJ=8927220400en_HK
dc.identifier.citeulike6230305-

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