File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The effectiveness and safety of acupuncture therapy in depressive disorders: Systematic review and meta-analysis

TitleThe effectiveness and safety of acupuncture therapy in depressive disorders: Systematic review and meta-analysis
Authors
KeywordsAcupuncture
Major depressive disorder
Meta-analysis
Post-stroke depression
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jad
Citation
Journal Of Affective Disorders, 2010, v. 124 n. 1-2, p. 9-21 How to Cite?
AbstractBackground: Although acupuncture has been used as an alternative treatment for depressive disorders, its effectiveness and safety are not well defined. The purpose of this systematic review with meta-analysis was to evaluate the effectiveness of acupuncture as monotherapy and as an additional therapy in treating various depressive conditions, particularly major depressive disorder (MDD) and post-stroke depression (PSD). Methods: Following systematic review, meta-analysis was conducted on high-quality randomized controlled trials (RCTs). Results: Of 207 clinical studies of acupuncture for various depression retrieved, 113 (54.6%) were on MDD and 76 (36.7%) on PSD. Twenty RCTs of MDD (n = 1998) and 15 of PSD (n = 1680) identified for high-quality protocol (Jadad score ≥ 3) were included for meta-analysis. The efficacy of acupuncture as monotherapy was comparable to antidepressants alone in improving clinical response and alleviating symptom severity of MDD, but not different from sham acupuncture. No sufficient evidence favored the expectation that acupuncture combined with antidepressants could yield better outcomes than antidepressants alone in treating MDD. Acupuncture was superior to antidepressants and waitlist controls in improving both response and symptom severity of PSD. The incidence of adverse events in acupuncture intervention was significantly lower than antidepressants. Conclusions: Acupuncture therapy is safe and effective in treating MDD and PSD, and could be considered an alternative option for the two disorders. The efficacy in other forms of depression remains to be further determined. © 2009 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/127590
ISSN
2015 Impact Factor: 3.57
2015 SCImago Journal Rankings: 1.927
ISI Accession Number ID
Funding AgencyGrant Number
Hospital Authority of Hong Kong
Funding Information:

The present study was supported by the Hospital Authority of Hong Kong. The authors thank Mr. Steven E. Zhang for grammatically reading the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZJen_HK
dc.contributor.authorChen, HYen_HK
dc.contributor.authorYip, Kcen_HK
dc.contributor.authorNg, Ren_HK
dc.contributor.authorWong, VTen_HK
dc.date.accessioned2010-10-31T13:34:22Z-
dc.date.available2010-10-31T13:34:22Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Affective Disorders, 2010, v. 124 n. 1-2, p. 9-21en_HK
dc.identifier.issn0165-0327en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127590-
dc.description.abstractBackground: Although acupuncture has been used as an alternative treatment for depressive disorders, its effectiveness and safety are not well defined. The purpose of this systematic review with meta-analysis was to evaluate the effectiveness of acupuncture as monotherapy and as an additional therapy in treating various depressive conditions, particularly major depressive disorder (MDD) and post-stroke depression (PSD). Methods: Following systematic review, meta-analysis was conducted on high-quality randomized controlled trials (RCTs). Results: Of 207 clinical studies of acupuncture for various depression retrieved, 113 (54.6%) were on MDD and 76 (36.7%) on PSD. Twenty RCTs of MDD (n = 1998) and 15 of PSD (n = 1680) identified for high-quality protocol (Jadad score ≥ 3) were included for meta-analysis. The efficacy of acupuncture as monotherapy was comparable to antidepressants alone in improving clinical response and alleviating symptom severity of MDD, but not different from sham acupuncture. No sufficient evidence favored the expectation that acupuncture combined with antidepressants could yield better outcomes than antidepressants alone in treating MDD. Acupuncture was superior to antidepressants and waitlist controls in improving both response and symptom severity of PSD. The incidence of adverse events in acupuncture intervention was significantly lower than antidepressants. Conclusions: Acupuncture therapy is safe and effective in treating MDD and PSD, and could be considered an alternative option for the two disorders. The efficacy in other forms of depression remains to be further determined. © 2009 Elsevier B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jaden_HK
dc.relation.ispartofJournal of Affective Disordersen_HK
dc.subjectAcupunctureen_HK
dc.subjectMajor depressive disorderen_HK
dc.subjectMeta-analysisen_HK
dc.subjectPost-stroke depressionen_HK
dc.subject.meshAcupuncture Therapy - adverse effects-
dc.subject.meshAntidepressive Agents - adverse effects - therapeutic use-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshDepressive Disorder - diagnosis - psychology - therapy-
dc.subject.meshDepressive Disorder, Major - diagnosis - psychology - therapy-
dc.titleThe effectiveness and safety of acupuncture therapy in depressive disorders: Systematic review and meta-analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0165-0327&volume=124&issue=1-2&spage=9&epage=21&date=2010&atitle=The+effectiveness+and+safety+of+acupuncture+therapy+in+depressive+disorders:+systematic+review+and+meta-analysisen_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jad.2009.07.005en_HK
dc.identifier.pmid19632725-
dc.identifier.scopuseid_2-s2.0-77952289311en_HK
dc.identifier.hkuros174208en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952289311&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage9en_HK
dc.identifier.epage21en_HK
dc.identifier.eissn1573-2517-
dc.identifier.isiWOS:000278787400002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK
dc.identifier.scopusauthoridChen, HY=39862601300en_HK
dc.identifier.scopusauthoridYip, Kc=28168097100en_HK
dc.identifier.scopusauthoridNg, R=7102153803en_HK
dc.identifier.scopusauthoridWong, VT=16176799600en_HK
dc.identifier.citeulike5304922-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats