File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes

TitleProduction of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes
Authors
KeywordsChinese medicine
Immunomodulation
Rhodiola algida
Th1- and Th2-dependent cytokine
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
Citation
Journal Of Ethnopharmacology, 2009, v. 123 n. 2, p. 257-266 How to Cite?
AbstractEthnopharmacological relevance: Rhodiola algida, an herb ingredient used in Chinese medicine, has been clinically proven to be effective in enhancing human immune responses. Aim of study: This study attempted to identify the potential immunomodulatory effect of Rhodiola algida extract in human immune system in vitro, and to examine its underlying molecular effects. Materials and methods: Firstly, the bioactive marker compound salidroside was used for standardization of Rhodiola algida extract by reversed-phase HPLC. Secondly, the regulation of human immune responses was investigated in human peripheral blood monocytes. A series of cytokines known to play important roles in the human immune responses were examined. Results: The current study provided quantitative assay for the marker compound, salidroside, in the Rhodiola algida extract for ensuring the quality consistency of Rhodiola algida used in the following experiments. Biological assay indicated that Rhodiola algida stimulates human peripheral blood lymphocytes and its underlying immunomodulatory effects probably through its regulation of IL-2 in Th1 cells and IL-4, IL-6, IL-10 in Th2 cells. Conclusion: The findings may enable us to further explain the pharmacological properties in Chinese medicine and make Rhodiola algida a very promising immunomodulating agent. © 2009 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/127589
ISSN
2015 Impact Factor: 3.055
2015 SCImago Journal Rankings: 1.156
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200707176167
Funding Information:

This research was supported in part by a grant from Small Project Funding of the University of Hong Kong (no. 200707176167).

References

 

DC FieldValueLanguage
dc.contributor.authorLi, HXen_HK
dc.contributor.authorSze, SCWen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorNg, TBen_HK
dc.date.accessioned2010-10-31T13:34:19Z-
dc.date.available2010-10-31T13:34:19Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Ethnopharmacology, 2009, v. 123 n. 2, p. 257-266en_HK
dc.identifier.issn0378-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127589-
dc.description.abstractEthnopharmacological relevance: Rhodiola algida, an herb ingredient used in Chinese medicine, has been clinically proven to be effective in enhancing human immune responses. Aim of study: This study attempted to identify the potential immunomodulatory effect of Rhodiola algida extract in human immune system in vitro, and to examine its underlying molecular effects. Materials and methods: Firstly, the bioactive marker compound salidroside was used for standardization of Rhodiola algida extract by reversed-phase HPLC. Secondly, the regulation of human immune responses was investigated in human peripheral blood monocytes. A series of cytokines known to play important roles in the human immune responses were examined. Results: The current study provided quantitative assay for the marker compound, salidroside, in the Rhodiola algida extract for ensuring the quality consistency of Rhodiola algida used in the following experiments. Biological assay indicated that Rhodiola algida stimulates human peripheral blood lymphocytes and its underlying immunomodulatory effects probably through its regulation of IL-2 in Th1 cells and IL-4, IL-6, IL-10 in Th2 cells. Conclusion: The findings may enable us to further explain the pharmacological properties in Chinese medicine and make Rhodiola algida a very promising immunomodulating agent. © 2009 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharmen_HK
dc.relation.ispartofJournal of Ethnopharmacologyen_HK
dc.rightsJournal of Ethnopharmacology. Copyright © Elsevier Ireland Ltd.-
dc.subjectChinese medicineen_HK
dc.subjectImmunomodulationen_HK
dc.subjectRhodiola algidaen_HK
dc.subjectTh1- and Th2-dependent cytokineen_HK
dc.subject.meshChromatography, High Pressure Liquid-
dc.subject.meshCytokines - drug effects - immunology-
dc.subject.meshMonocytes - drug effects - immunology-
dc.subject.meshPlant Extracts - administration and dosage - pharmacology - standards-
dc.subject.meshRhodiola - chemistry-
dc.titleProduction of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-8741&volume=123&issue=2&spage=257–266&epage=&date=2009&atitle=Production+of+Th1-+and+Th2-dependent+Cytokines+Induced+by+the+Chinese+Medicine+Herb,+Rhodiola+algida,+on+Human+Peripheral+Blood+Monocytesen_HK
dc.identifier.emailSze, SCW: stephens@hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.authoritySze, SCW=rp00514en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jep.2009.03.009en_HK
dc.identifier.pmid19429370-
dc.identifier.scopuseid_2-s2.0-67349092387en_HK
dc.identifier.hkuros181705en_HK
dc.identifier.hkuros162843-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349092387&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume123en_HK
dc.identifier.issue2en_HK
dc.identifier.spage257en_HK
dc.identifier.epage266en_HK
dc.identifier.isiWOS:000266511300009-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridLi, HX=35083887800en_HK
dc.identifier.scopusauthoridSze, SCW=23482617000en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridNg, TB=35311803300en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats