Article: Cellular response to influenza virus infection: A potential role for autophagy in CXCL10 and interferon-alpha induction
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- Publisher Website: 10.1038/cmi.2010.25
- Scopus: eid_2-s2.0-77957284249
- PMID: 20473322
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| Title | Cellular response to influenza virus infection: A potential role for autophagy in CXCL10 and interferon-alpha induction |
|---|---|
| Authors | Law, AHY1 Lee, DCW1 Yuen, KY1 Peiris, M1 Lau, ASY1 |
| Keywords | autophagy CXCL10 influenza interferon |
| Issue Date | 2010 |
| Publisher | Chinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html |
| Citation | Cellular And Molecular Immunology, 2010, v. 7 n. 4, p. 263-270 [How to Cite?] DOI: http://dx.doi.org/10.1038/cmi.2010.25 |
| Abstract | Historically, influenza pandemics have arisen from avian influenza viruses. Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates. Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%, which has been attributed to dysregulation of the cytokine system. Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus. The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated. In the present study, we demonstrate that autophagy, a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents, plays a role in cytokine induction. Autophagy is induced to a greater extent by H9N2/G1, in association with cytokine hyperinduction, compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses. Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene, Atg5, we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-α expression in primary human blood macrophages. Our results provide new insights into the pathogenic mechanisms of avian influenza viruses. © 2010 CSI and USTC. All rights reserved. |
| ISSN | 1672-7681 2011 Impact Factor: 2.992 2011 SCImago Journal Rankings: 0.341 |
| DOI | http://dx.doi.org/10.1038/cmi.2010.25 |
| References | References in Scopus |
| Grants | Control of Pandemic and Inter-pandemic Influenza Cellular response to influenza virus infection: effect of autophagy versus apoptosis on virus replication Pathogenesis, cell signaling and virus evolution of avian influenza A (H5N1) |
| dc.contributor.author | Law, AHY | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Lee, DCW | ||||||||
| dc.contributor.author | Yuen, KY | ||||||||
| dc.contributor.author | Peiris, M | ||||||||
| dc.contributor.author | Lau, ASY | ||||||||
| dc.date.accessioned | 2010-10-31T13:34:16Z | ||||||||
| dc.date.available | 2010-10-31T13:34:16Z | ||||||||
| dc.date.issued | 2010 | ||||||||
| dc.description.abstract | Historically, influenza pandemics have arisen from avian influenza viruses. Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates. Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%, which has been attributed to dysregulation of the cytokine system. Human macrophages and epithelial cells infected with some genotypes of H5N1 and H9N2 viruses express markedly elevated cytokine and chemokine levels when compared with seasonal influenza A subtype H1N1 virus. The mechanisms underlying this cytokine and chemokine hyperinduction are not fully elucidated. In the present study, we demonstrate that autophagy, a tightly regulated homeostatic process for self-digestion of unwanted cellular subcomponents, plays a role in cytokine induction. Autophagy is induced to a greater extent by H9N2/G1, in association with cytokine hyperinduction, compared with H1N1 and the novel pandemic swine-origin influenza A/H1N1 viruses. Using 3-methyladenine to inhibit autophagy and small interfering RNA to silence the autophagy gene, Atg5, we further show that autophagic responses play a role in influenza virus-induced CXCL10 and interferon-α expression in primary human blood macrophages. Our results provide new insights into the pathogenic mechanisms of avian influenza viruses. © 2010 CSI and USTC. All rights reserved. | ||||||||
| dc.description.grant | Control of Pandemic and Inter-pandemic Influenza | ||||||||
| dc.description.grant | Cellular response to influenza virus infection: effect of autophagy versus apoptosis on virus replication | ||||||||
| dc.description.grant | Pathogenesis, cell signaling and virus evolution of avian influenza A (H5N1) | ||||||||
| dc.description.grantcode | 97655 | ||||||||
| dc.description.grantcode | 100930 | ||||||||
| dc.description.grantcode | 81826 | ||||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||||
| dc.identifier.citation | Cellular And Molecular Immunology, 2010, v. 7 n. 4, p. 263-270 [How to Cite?] DOI: http://dx.doi.org/10.1038/cmi.2010.25 | ||||||||
| dc.identifier.citeulike | 9903765 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1038/cmi.2010.25 | ||||||||
| dc.identifier.epage | 270 | ||||||||
| dc.identifier.hkuros | 179327 | ||||||||
| dc.identifier.isi | WOS:000279487500005
Funding Information: This work was supported by Area of Excellence grants to Malik Peiris, K. Y. Yuen and Allan S. Lau (Grant AoE/M-12/06) from the Research Grants Council of Hong Kong and the Research Fund for Control of Infectious Disease (09080832), as well as grants to Allan S. Lau and Malik Peiris from the Research Grants Council Central Allocation (HKU 1/05C). | ||||||||
| dc.identifier.issn | 1672-7681 2011 Impact Factor: 2.992 2011 SCImago Journal Rankings: 0.341 | ||||||||
| dc.identifier.issue | 4 | ||||||||
| dc.identifier.openurl | | ||||||||
| dc.identifier.pmid | 20473322 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-77957284249 | ||||||||
| dc.identifier.spage | 263 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/127588 | ||||||||
| dc.identifier.volume | 7 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | Chinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html | ||||||||
| dc.publisher.place | China | ||||||||
| dc.relation.ispartof | Cellular and Molecular Immunology | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.subject.mesh | Autophagy - immunology | ||||||||
| dc.subject.mesh | Chemokine CXCL10 - biosynthesis | ||||||||
| dc.subject.mesh | Influenza A virus - immunology | ||||||||
| dc.subject.mesh | Influenza, Human - immunology - virology | ||||||||
| dc.subject.mesh | Interferon-alpha - biosynthesis | ||||||||
| dc.subject | autophagy | ||||||||
| dc.subject | CXCL10 | ||||||||
| dc.subject | influenza | ||||||||
| dc.subject | interferon | ||||||||
| dc.title | Cellular response to influenza virus infection: A potential role for autophagy in CXCL10 and interferon-alpha induction | ||||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine