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Article: Cytoskeletal dynamics and spermatogenesis

TitleCytoskeletal dynamics and spermatogenesis
Authors
KeywordsActin
Blood-testis barrier
Ectoplasmic specialization
Spermatogenesis
Testis
Issue Date2010
PublisherThe Royal Society. The Journal's web site is located at http://www.pubs.royalsoc.ac.uk/index.cfm?page=1085
Citation
Philosophical Transactions Of The Royal Society B: Biological Sciences, 2010, v. 365 n. 1546, p. 1581-1592 How to Cite?
AbstractDifferent cellular events occur during spermatogenesis, and these include (i) mitosis for self-renewa of spermatogonia, (ii) differentiation of type A spermatogonia into type B and commitment of type B spermatogonia to develop into preleptotene primary spermatocytes, (iii) transit of preleptotene, leptotene spermatocytes across the blood-testis barrier in coordination with germ cell cycle progression and meiosis, (iv) spermiogenesis and spermiation. These events also associate with extensive changes in cell shape and size, and germ cell movement. The cytoskeleton, which comprises actin, microtubules and intermediate filaments, is believed to function in these cellular events. However, few studies have been conducted by investigators in the past decades to unfold the role of the cytoskeleton during spermatogenesis. This review summarizes recent advances in the field relating to cytoskeletal dynamics in the testis, and highlights areas of research that require additional emphasis so that new approaches for male contraception, as well as therapeutic approaches to alleviate environmental toxicant-induced reproductive dysfunction in men, can possibly be developed. © 2010 The Royal Society.
Persistent Identifierhttp://hdl.handle.net/10722/127453
ISSN
2015 Impact Factor: 5.847
2015 SCImago Journal Rankings: 2.659
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of Health (NICHD)U54 HD029 990
R01 HD056 034
R03 HD061 401
Hong Kong Research Grants Council (HKU)7693/07M
Funding Information:

This work was supported in part by grants from the National Institutes of Health (NICHD, U54 HD029 990, Project 5 and R01 HD056 034 to CYC; R03 HD061 401 to DDM) and Hong Kong Research Grants Council (HKU 7693/07M to WML).

References

 

DC FieldValueLanguage
dc.contributor.authorLie, PPYen_HK
dc.contributor.authorMruk, DDen_HK
dc.contributor.authorLee, WMen_HK
dc.contributor.authorCheng, CYen_HK
dc.date.accessioned2010-10-31T13:26:26Z-
dc.date.available2010-10-31T13:26:26Z-
dc.date.issued2010en_HK
dc.identifier.citationPhilosophical Transactions Of The Royal Society B: Biological Sciences, 2010, v. 365 n. 1546, p. 1581-1592en_HK
dc.identifier.issn0962-8436en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127453-
dc.description.abstractDifferent cellular events occur during spermatogenesis, and these include (i) mitosis for self-renewa of spermatogonia, (ii) differentiation of type A spermatogonia into type B and commitment of type B spermatogonia to develop into preleptotene primary spermatocytes, (iii) transit of preleptotene, leptotene spermatocytes across the blood-testis barrier in coordination with germ cell cycle progression and meiosis, (iv) spermiogenesis and spermiation. These events also associate with extensive changes in cell shape and size, and germ cell movement. The cytoskeleton, which comprises actin, microtubules and intermediate filaments, is believed to function in these cellular events. However, few studies have been conducted by investigators in the past decades to unfold the role of the cytoskeleton during spermatogenesis. This review summarizes recent advances in the field relating to cytoskeletal dynamics in the testis, and highlights areas of research that require additional emphasis so that new approaches for male contraception, as well as therapeutic approaches to alleviate environmental toxicant-induced reproductive dysfunction in men, can possibly be developed. © 2010 The Royal Society.en_HK
dc.languageengen_HK
dc.publisherThe Royal Society. The Journal's web site is located at http://www.pubs.royalsoc.ac.uk/index.cfm?page=1085en_HK
dc.relation.ispartofPhilosophical Transactions of the Royal Society B: Biological Sciencesen_HK
dc.subjectActinen_HK
dc.subjectBlood-testis barrieren_HK
dc.subjectEctoplasmic specializationen_HK
dc.subjectSpermatogenesisen_HK
dc.subjectTestisen_HK
dc.subject.meshCell Communication - physiology-
dc.subject.meshCytoskeletal Proteins - physiology-
dc.subject.meshCytoskeleton - physiology-
dc.subject.meshHumans-
dc.subject.meshSpermatogenesis - physiology-
dc.titleCytoskeletal dynamics and spermatogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0962-8436&volume=365 no. 1546&spage=1581&epage=1592&date=2010&atitle=Cytoskeletal+dynamics+and+spermatogenesis-
dc.identifier.emailLee, WM: hrszlwm@hku.hken_HK
dc.identifier.authorityLee, WM=rp00728en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1098/rstb.2009.0261en_HK
dc.identifier.pmid20403871-
dc.identifier.pmcidPMC2871923-
dc.identifier.scopuseid_2-s2.0-77952748637en_HK
dc.identifier.hkuros179023en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952748637&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume365en_HK
dc.identifier.issue1546en_HK
dc.identifier.spage1581en_HK
dc.identifier.epage1592en_HK
dc.identifier.isiWOS:000276797500009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLie, PPY=15839862700en_HK
dc.identifier.scopusauthoridMruk, DD=6701823934en_HK
dc.identifier.scopusauthoridLee, WM=24799156600en_HK
dc.identifier.scopusauthoridCheng, CY=7404797787en_HK
dc.identifier.citeulike7073005-

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