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Article: Protein interactors of acyl-CoA-binding protein ACBP2 mediate cadmium tolerance in arabidopsis

TitleProtein interactors of acyl-CoA-binding protein ACBP2 mediate cadmium tolerance in arabidopsis
Authors
KeywordsAcyl-CoA-binding protein
Cadmium
Hydrogen peroxide
Lysophospholipase
Oxidative stress
Issue Date2010
PublisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/psb
Citation
Plant Signaling And Behavior, 2010, v. 5 n. 8, p. 1025-1027 How to Cite?
AbstractIn our recent paper in the Plant Journal, we reported that Arabidopsis thaliana lysophospholipase 2 (lysoPL2) binds acyl-CoA-binding protein 2 (ACBP2) to mediate cadmium [Cd(II)] tolerance in transgenic Arabidopsis. ACBP2 contains ankyrin repeats that have been previously shown to mediate protein-protein interactions with an ethylene-responsive element binding protein (AtEBP) and a farnesylated protein 6 (AtFP6). Transgenic Arabidopsis ACBP2- overexpressors, lysoPL2-overexpressors and AtFP6-overexpressors all display enhanced Cd(II) tolerance, in comparison to wild type, suggesting that ACBP2 and its protein partners work together to mediate Cd(II) tolerance. Given that recombinant ACBP2 and AtFP6 can independently bind Cd(II) in vitro, they may be able to participate in Cd(II) translocation. The binding of recombinant ACBP2 to [14C]linoleoyl-CoA and [14C]linolenoyl-CoA implies its role in phospholipid repair. In conclusion, ACBP2 can mediate tolerance to Cd(II)- induced oxidative stress by interacting with two protein partners, AtFP6 and lysoPL2. Observations that ACBP2 also binds lysophosphatidylcholine (lysoPC) in vitro and that recombinant lysoPL2 degrades lysoPC, further confirm an interactive role for ACBP2 and lysoPL2 in overcoming Cd(II)-induced stress. © 2010 Landes Bioscience.
Persistent Identifierhttp://hdl.handle.net/10722/127448
ISSN
2015 SCImago Journal Rankings: 0.633
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorGao, Wen_HK
dc.contributor.authorLi, HYen_HK
dc.contributor.authorXiao, Sen_HK
dc.contributor.authorChye, MLen_HK
dc.date.accessioned2010-10-31T13:26:09Z-
dc.date.available2010-10-31T13:26:09Z-
dc.date.issued2010en_HK
dc.identifier.citationPlant Signaling And Behavior, 2010, v. 5 n. 8, p. 1025-1027en_HK
dc.identifier.issn1559-2316en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127448-
dc.description.abstractIn our recent paper in the Plant Journal, we reported that Arabidopsis thaliana lysophospholipase 2 (lysoPL2) binds acyl-CoA-binding protein 2 (ACBP2) to mediate cadmium [Cd(II)] tolerance in transgenic Arabidopsis. ACBP2 contains ankyrin repeats that have been previously shown to mediate protein-protein interactions with an ethylene-responsive element binding protein (AtEBP) and a farnesylated protein 6 (AtFP6). Transgenic Arabidopsis ACBP2- overexpressors, lysoPL2-overexpressors and AtFP6-overexpressors all display enhanced Cd(II) tolerance, in comparison to wild type, suggesting that ACBP2 and its protein partners work together to mediate Cd(II) tolerance. Given that recombinant ACBP2 and AtFP6 can independently bind Cd(II) in vitro, they may be able to participate in Cd(II) translocation. The binding of recombinant ACBP2 to [14C]linoleoyl-CoA and [14C]linolenoyl-CoA implies its role in phospholipid repair. In conclusion, ACBP2 can mediate tolerance to Cd(II)- induced oxidative stress by interacting with two protein partners, AtFP6 and lysoPL2. Observations that ACBP2 also binds lysophosphatidylcholine (lysoPC) in vitro and that recombinant lysoPL2 degrades lysoPC, further confirm an interactive role for ACBP2 and lysoPL2 in overcoming Cd(II)-induced stress. © 2010 Landes Bioscience.en_HK
dc.languageengen_HK
dc.publisherLandes Bioscience. The Journal's web site is located at http://www.landesbioscience.com/journals/psben_HK
dc.relation.ispartofPlant Signaling and Behavioren_HK
dc.subjectAcyl-CoA-binding proteinen_HK
dc.subjectCadmiumen_HK
dc.subjectHydrogen peroxideen_HK
dc.subjectLysophospholipaseen_HK
dc.subjectOxidative stressen_HK
dc.titleProtein interactors of acyl-CoA-binding protein ACBP2 mediate cadmium tolerance in arabidopsisen_HK
dc.typeArticleen_HK
dc.identifier.emailXiao, S: xiaoshi@graduate.hku.hken_HK
dc.identifier.emailChye, ML: mlchye@hkucc.hku.hken_HK
dc.identifier.authorityXiao, S=rp00817en_HK
dc.identifier.authorityChye, ML=rp00687en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid20657176-
dc.identifier.pmcidPMC3115187-
dc.identifier.scopuseid_2-s2.0-77957727621en_HK
dc.identifier.hkuros182340en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957727621&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume5en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1025en_HK
dc.identifier.epage1027en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGao, W=36045713300en_HK
dc.identifier.scopusauthoridLi, HY=51061323000en_HK
dc.identifier.scopusauthoridXiao, S=7402022635en_HK
dc.identifier.scopusauthoridChye, ML=7003905460en_HK

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