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Article: Phylogeny-based evolutionary, demographical, and geographical dissection of north american type 2 porcine reproductive and respiratory syndrome viruses

TitlePhylogeny-based evolutionary, demographical, and geographical dissection of north american type 2 porcine reproductive and respiratory syndrome viruses
Authors
Issue Date2010
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/
Citation
Journal Of Virology, 2010, v. 84 n. 17, p. 8700-8711 How to Cite?
AbstractType 2 (or North American-like) porcine reproductive and respiratory syndrome virus (PRRSV) was first recorded in 1987 in the United States and now occurs in most commercial swine industries throughout the world. In this study, we investigated the epidemiological and evolutionary behaviors of type 2 PRRSV. Based on phylogenetic analyses of 8,624 ORF5 sequences, we described a comprehensive picture of the diversity of type 2 PRRSVs and systematically classified all available sequences into lineages and sublineages, including a number of previously undescribed lineages. With the rapid growth of sequence deposition into the databases, it would be technically difficult for veterinary researchers to genotype their sequences by reanalyzing all sequences in the databases. To this end, a set of reference sequences was established based on our classification system, which represents the principal diversity of all available sequences and can readily be used for further genotyping studies. In addition, we further investigated the demographic histories of these lineages and sublineages by using Bayesian coalescence analyses, providing evolutionary insights into several important epidemiological events of type 2 PRRSV. Moreover, by using a phylogeographic approach, we were able to estimate the transmission frequencies between the pig-producing states in the United States and identified several states as the major sources of viral spread, i.e., "transmission centers." In summary, this study represents the most extensive phylogenetic analyses of type 2 PRRSV to date, providing a basis for future genotyping studies and dissecting the epidemiology of type 2 PRRSV from phylogenetic perspectives. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/127413
ISSN
2015 Impact Factor: 4.606
2015 SCImago Journal Rankings: 3.347
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Strategic Research Theme of Infection and Immunology, The University of Hong Kong
Funding Information:

This work was partially supported by the Strategic Research Theme of Infection and Immunology, The University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorShi, Men_HK
dc.contributor.authorLam, TTYen_HK
dc.contributor.authorHon, CCen_HK
dc.contributor.authorMurtaugh, MPen_HK
dc.contributor.authorDavies, PRen_HK
dc.contributor.authorHui, RKHen_HK
dc.contributor.authorLi, Jen_HK
dc.contributor.authorWong, LTWen_HK
dc.contributor.authorYip, CWen_HK
dc.contributor.authorJiang, JWen_HK
dc.contributor.authorLeung, FCCen_HK
dc.date.accessioned2010-10-31T13:24:11Z-
dc.date.available2010-10-31T13:24:11Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Virology, 2010, v. 84 n. 17, p. 8700-8711en_HK
dc.identifier.issn0022-538Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/127413-
dc.description.abstractType 2 (or North American-like) porcine reproductive and respiratory syndrome virus (PRRSV) was first recorded in 1987 in the United States and now occurs in most commercial swine industries throughout the world. In this study, we investigated the epidemiological and evolutionary behaviors of type 2 PRRSV. Based on phylogenetic analyses of 8,624 ORF5 sequences, we described a comprehensive picture of the diversity of type 2 PRRSVs and systematically classified all available sequences into lineages and sublineages, including a number of previously undescribed lineages. With the rapid growth of sequence deposition into the databases, it would be technically difficult for veterinary researchers to genotype their sequences by reanalyzing all sequences in the databases. To this end, a set of reference sequences was established based on our classification system, which represents the principal diversity of all available sequences and can readily be used for further genotyping studies. In addition, we further investigated the demographic histories of these lineages and sublineages by using Bayesian coalescence analyses, providing evolutionary insights into several important epidemiological events of type 2 PRRSV. Moreover, by using a phylogeographic approach, we were able to estimate the transmission frequencies between the pig-producing states in the United States and identified several states as the major sources of viral spread, i.e., "transmission centers." In summary, this study represents the most extensive phylogenetic analyses of type 2 PRRSV to date, providing a basis for future genotyping studies and dissecting the epidemiology of type 2 PRRSV from phylogenetic perspectives. Copyright © 2010, American Society for Microbiology. All Rights Reserved.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/en_HK
dc.relation.ispartofJournal of Virologyen_HK
dc.rightsJournal of Virology. Copyright © American Society for Microbiology.-
dc.subject.meshEvolution, Molecular-
dc.subject.meshPhylogeny-
dc.subject.meshPorcine Reproductive and Respiratory Syndrome - transmission - virology-
dc.subject.meshPorcine respiratory and reproductive syndrome virus - classification - genetics - isolation and purification-
dc.subject.meshSwine-
dc.titlePhylogeny-based evolutionary, demographical, and geographical dissection of north american type 2 porcine reproductive and respiratory syndrome virusesen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TTY: ttylam@hku.hken_HK
dc.identifier.emailHui, RKH: rkhhui@hkucc.hku.hken_HK
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hken_HK
dc.identifier.authorityLam, TTY=rp01733en_HK
dc.identifier.authorityHui, RKH=rp00711en_HK
dc.identifier.authorityLeung, FCC=rp00731en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1128/JVI.02551-09en_HK
dc.identifier.pmid20554771-
dc.identifier.pmcidPMC2919017-
dc.identifier.scopuseid_2-s2.0-77956626910en_HK
dc.identifier.hkuros181262en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956626910&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume84en_HK
dc.identifier.issue17en_HK
dc.identifier.spage8700en_HK
dc.identifier.epage8711en_HK
dc.identifier.isiWOS:000280605300030-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShi, M=25951822000en_HK
dc.identifier.scopusauthoridLam, TTY=36775821700en_HK
dc.identifier.scopusauthoridHon, CC=7003617137en_HK
dc.identifier.scopusauthoridMurtaugh, MP=7005137127en_HK
dc.identifier.scopusauthoridDavies, PR=7403894608en_HK
dc.identifier.scopusauthoridHui, RKH=7103304764en_HK
dc.identifier.scopusauthoridLi, J=36013243900en_HK
dc.identifier.scopusauthoridWong, LTW=36478099600en_HK
dc.identifier.scopusauthoridYip, CW=7101665559en_HK
dc.identifier.scopusauthoridJiang, JW=36477399900en_HK
dc.identifier.scopusauthoridLeung, FCC=7103078633en_HK

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