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Conference Paper: rs10795668 located at 10p14 is associated with colorectal cancer risk in Han Chinese

Titlers10795668 located at 10p14 is associated with colorectal cancer risk in Han Chinese
Authors
Issue Date2009
PublisherNational Cancer Research Institute.
Citation
The 2009 NCRI Cancer Conference, Birmingham, U.K., 4-7 October 2009. How to Cite?
AbstractBACKGROUND: Colorectal cancer (CRC) is the second commonest cancer in Hong Kong. While high-penetrance germline mutations account for <6% of cases, much of the remaining variation in genetic risk (30%) may be attributable to multiple low-penetrance variants. Previous genome-wide association studies (GWAS) have identified a number of CRC susceptibility alleles in the Caucasian population. Our study investigated the association of 13 previously reported SNPs with CRC risk in the Han Chinese population in Hong Kong. METHOD: Genomic DNA samples from 1,440 Chinese subjects were genotyped using the Sequenom Mass ARRAY system. Association analysis was successfully performed on 714 cases (male = 444; female = 270) and 717 controls (male = 442; female = 275) with an overall genotyping call rate of 99.87%. PLINK was used for quality-control testing and data analysis. Allelic frequencies were compared by chi-squared tests and one-tailed p-values were corrected for multiple testing using Bonferroni and False Discovery Rate (FDR). RESULTS: One SNP, rs10795668 located at 10p14, was found to be significantly associated with CRC (Bonferroni corrected p = 0.016), with effect size similar to Caucasian data (OR = 0.79, 95% CI 0.68-0.92). Using a FDR of 0.1, four additional SNPs (rs4779584, rs12953717, rs7014346 and rs4939827) were also found to be significant. Q-Q plot showed that all 13 p-values were more significant than the expectations for their ranks, under the null hypothesis of a uniform distribution of p-values. CONCLUSION: Our study shows that rs10795668 is associated with CRC risk in Hong Kong Han Chinese. Inadequate sample size may have led to under-estimation of the number of SNPs that are truly associated with CRC risk in our population. This result corroborates with previous findings in the Caucasian population.
DescriptionPoster Session C - Colorectal cancer: abstract no. C53
Persistent Identifierhttp://hdl.handle.net/10722/127007

 

DC FieldValueLanguage
dc.contributor.authorLee, YFen_HK
dc.contributor.authorChoi, SCen_HK
dc.contributor.authorHui, TCKen_HK
dc.contributor.authorTomlinson, Ien_HK
dc.contributor.authorHoulston, RSen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorHo, JWCen_HK
dc.date.accessioned2010-10-31T13:01:00Z-
dc.date.available2010-10-31T13:01:00Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 2009 NCRI Cancer Conference, Birmingham, U.K., 4-7 October 2009.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/127007-
dc.descriptionPoster Session C - Colorectal cancer: abstract no. C53-
dc.description.abstractBACKGROUND: Colorectal cancer (CRC) is the second commonest cancer in Hong Kong. While high-penetrance germline mutations account for <6% of cases, much of the remaining variation in genetic risk (30%) may be attributable to multiple low-penetrance variants. Previous genome-wide association studies (GWAS) have identified a number of CRC susceptibility alleles in the Caucasian population. Our study investigated the association of 13 previously reported SNPs with CRC risk in the Han Chinese population in Hong Kong. METHOD: Genomic DNA samples from 1,440 Chinese subjects were genotyped using the Sequenom Mass ARRAY system. Association analysis was successfully performed on 714 cases (male = 444; female = 270) and 717 controls (male = 442; female = 275) with an overall genotyping call rate of 99.87%. PLINK was used for quality-control testing and data analysis. Allelic frequencies were compared by chi-squared tests and one-tailed p-values were corrected for multiple testing using Bonferroni and False Discovery Rate (FDR). RESULTS: One SNP, rs10795668 located at 10p14, was found to be significantly associated with CRC (Bonferroni corrected p = 0.016), with effect size similar to Caucasian data (OR = 0.79, 95% CI 0.68-0.92). Using a FDR of 0.1, four additional SNPs (rs4779584, rs12953717, rs7014346 and rs4939827) were also found to be significant. Q-Q plot showed that all 13 p-values were more significant than the expectations for their ranks, under the null hypothesis of a uniform distribution of p-values. CONCLUSION: Our study shows that rs10795668 is associated with CRC risk in Hong Kong Han Chinese. Inadequate sample size may have led to under-estimation of the number of SNPs that are truly associated with CRC risk in our population. This result corroborates with previous findings in the Caucasian population.-
dc.languageengen_HK
dc.publisherNational Cancer Research Institute.-
dc.relation.ispartofNCRI Cancer Conference-
dc.titlers10795668 located at 10p14 is associated with colorectal cancer risk in Han Chineseen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChoi, SC: scchoi66@hku.hken_HK
dc.identifier.emailHui, TCK: ckhui@hku.hk-
dc.identifier.emailHoulston, RS: Richard.Houlston@icr.ac.uk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.emailHo, JWC: judyho@hkucc.hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros179022en_HK
dc.publisher.placeUnited Kingdom-
dc.description.otherThe 2009 NCRI Cancer Conference, Birmingham, U.K., 4-7 October 2009.-

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