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Conference Paper: Primary versus salvage liver transplantation for hepatocellular carcinoma within Milan criteria: a single center experience

TitlePrimary versus salvage liver transplantation for hepatocellular carcinoma within Milan criteria: a single center experience
Authors
KeywordsMedical sciences
Gastroenterology medical sciences
Surgery
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The 15th Annual International Congress of the International Liver Transplant Society (ILTS), New York, NY., 8-11 July 2009. In Liver Transplantation, 2010, v. 15 suppl. S7, p. S254, abstract no. P-456 How to Cite?
AbstractBACKGROUND: Under the pressure of the shortage of deceased liver graft, the application of primary liver transplant (PLT) for hepatocellular carcinoma (HCC) within Milan criteria is limited. The approach of primary hepatic resection and salvage liver transplant (SLT) for intrahepatic recurrence is then increasingly adopted. However, the comparison of survival outcome between PLT and SLT for HCC is controversial in the literature. AIM OF STUDY: To compare the long-term survival outcome between PLT and SLT for HCC within Milan criteria PATIENTS AND METHODS: From July 1995 to December 2007, a total of 75 patients who underwent liver transplant for HCC within Milan criteria were retrospectively analyzed. There were 67 patients receiving PLT (Group 1) and 8 patients receiving SLT after primary hepatic resection for recurrence (Group 2). Clinicopathologic characteristics, perioperative outcome and long-term survival were compared between the two groups. RESULTS: Patients in group 2 had better liver function in terms of lower Child-Pugh score and MELD score than those in group 1.There was higher proportion of patients receiving living donor liver transplant in group 2 (7 of 8 patients; 87.5%) than group 1 (50 of 67 patients; 74.6%). Waiting time was shorter and graft weight to standard liver weight ratio was lower in group 2 than group 1. Other clinicopathologic characteristics were comparable between the two groups. There were no significant differences between group 1 and 2 in morbidity rate (81 % vs. 75%) and mortality (15% vs. 13%). With median follow-up period of 36 months (range 4 – 120 months), the overall recurrence-free survival was significantly worse in group 2 than group 1 (1-year: 87.5% vs. 92.5%; 3-year: 72.9% vs. 86.1%; 5-year: 36.4% vs. 81.5%). CONCLUSION: Despite strict selection criteria based on tumor size and number, patients who underwent SLT had significantly worse recurrence-free survival than those receiving PLT for HCC.
DescriptionThis journal supplement is proceedings of the ILTS 15th Annual International Congress 2009
Poster Presentation: abstract no. P-456
Persistent Identifierhttp://hdl.handle.net/10722/127001
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorNg, KKCen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-10-31T13:00:41Z-
dc.date.available2010-10-31T13:00:41Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 15th Annual International Congress of the International Liver Transplant Society (ILTS), New York, NY., 8-11 July 2009. In Liver Transplantation, 2010, v. 15 suppl. S7, p. S254, abstract no. P-456en_HK
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/127001-
dc.descriptionThis journal supplement is proceedings of the ILTS 15th Annual International Congress 2009-
dc.descriptionPoster Presentation: abstract no. P-456-
dc.description.abstractBACKGROUND: Under the pressure of the shortage of deceased liver graft, the application of primary liver transplant (PLT) for hepatocellular carcinoma (HCC) within Milan criteria is limited. The approach of primary hepatic resection and salvage liver transplant (SLT) for intrahepatic recurrence is then increasingly adopted. However, the comparison of survival outcome between PLT and SLT for HCC is controversial in the literature. AIM OF STUDY: To compare the long-term survival outcome between PLT and SLT for HCC within Milan criteria PATIENTS AND METHODS: From July 1995 to December 2007, a total of 75 patients who underwent liver transplant for HCC within Milan criteria were retrospectively analyzed. There were 67 patients receiving PLT (Group 1) and 8 patients receiving SLT after primary hepatic resection for recurrence (Group 2). Clinicopathologic characteristics, perioperative outcome and long-term survival were compared between the two groups. RESULTS: Patients in group 2 had better liver function in terms of lower Child-Pugh score and MELD score than those in group 1.There was higher proportion of patients receiving living donor liver transplant in group 2 (7 of 8 patients; 87.5%) than group 1 (50 of 67 patients; 74.6%). Waiting time was shorter and graft weight to standard liver weight ratio was lower in group 2 than group 1. Other clinicopathologic characteristics were comparable between the two groups. There were no significant differences between group 1 and 2 in morbidity rate (81 % vs. 75%) and mortality (15% vs. 13%). With median follow-up period of 36 months (range 4 – 120 months), the overall recurrence-free survival was significantly worse in group 2 than group 1 (1-year: 87.5% vs. 92.5%; 3-year: 72.9% vs. 86.1%; 5-year: 36.4% vs. 81.5%). CONCLUSION: Despite strict selection criteria based on tumor size and number, patients who underwent SLT had significantly worse recurrence-free survival than those receiving PLT for HCC.-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantation-
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.subjectMedical sciences-
dc.subjectGastroenterology medical sciences-
dc.subjectSurgery-
dc.titlePrimary versus salvage liver transplantation for hepatocellular carcinoma within Milan criteria: a single center experienceen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailNg, KKC: kkcng@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/lt.21830-
dc.identifier.hkuros162039en_HK
dc.identifier.hkuros170135-
dc.identifier.hkuros180776-
dc.identifier.volume15-
dc.identifier.issuesuppl. S7-
dc.identifier.spageS254-
dc.identifier.epageS254-
dc.publisher.placeUnited States-
dc.description.otherThe 15th Annual International Congress of the International Liver Transplant Society (ILTS), New York, NY., 8-11 July 2009. In Liver Transplantation, 2010, v. 15 suppl. S7, p. S254, abstract no. P-456-

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