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Conference Paper: Prediction of surgical outcome using plasma epstein-barr virus dna and 18F-FDG PET-CT scan in recurrent nasopharyngeal carcinoma

TitlePrediction of surgical outcome using plasma epstein-barr virus dna and 18F-FDG PET-CT scan in recurrent nasopharyngeal carcinoma
Authors
Keywords18F-FDG PET-CT scan
lymph node metastasis
maxillary swing operation
pEBV-DNA
recurrent nasopharyngeal carcinoma
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
The 4th World Congress of International Federation of Head and Neck Oncologic Societies (IFHNOS 2010), Seoul, Korea, 15-19 June 2010. In Head & Neck, 2012, v. 34 n. 4, p. 541-545 How to Cite?
AbstractBackground This study was carried out to determine the role of plasma Epstein-Barr virus (pEBV)-DNA and positron-emission tomography (PET)-CT scan in predicting the outcome of nasopharyngectomy and cervical lymphadenectomy for recurrent nasopharyngeal carcinoma (NPC). Methods Between 2007 and 2009, we recruited patients who had local or regional recurrent NPC after radiotherapy. The relationship between preoperative pEBV-DNA level, maximal standard uptake value (SUVmax), and surgical outcome was analyzed. Results Forty-two patients had local tumor recurrence. Their median pEBV-DNA level and SUVmax were 348 copies and 4.7, respectively. Both values were significantly lower than those with palliative nasopharyngectomy. Twenty-two patients had regional failure. Their mean pEBV-DNA level and tumor SUVmax were 626 copies and 7.6, respectively. The metastatic lymph nodes with extracapsular spread had a significantly higher mean SUVmax. Conclusions Preoperative pEBV-DNA and PET-CT predict the surgical outcome of nasopharyngectomy for recurrent NPC. Similarly, PET-CT scan predicts the presence of extracapsular spread of metastatic lymph nodes. These patients may warrant further postoperative adjuvant therapy. Copyright © 2011 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/126946
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, JYWen_HK
dc.contributor.authorChow, VLYen_HK
dc.contributor.authorMok, VWKen_HK
dc.contributor.authorHo, ACWen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2010-10-31T12:57:39Z-
dc.date.available2010-10-31T12:57:39Z-
dc.date.issued2012en_HK
dc.identifier.citationThe 4th World Congress of International Federation of Head and Neck Oncologic Societies (IFHNOS 2010), Seoul, Korea, 15-19 June 2010. In Head & Neck, 2012, v. 34 n. 4, p. 541-545en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126946-
dc.description.abstractBackground This study was carried out to determine the role of plasma Epstein-Barr virus (pEBV)-DNA and positron-emission tomography (PET)-CT scan in predicting the outcome of nasopharyngectomy and cervical lymphadenectomy for recurrent nasopharyngeal carcinoma (NPC). Methods Between 2007 and 2009, we recruited patients who had local or regional recurrent NPC after radiotherapy. The relationship between preoperative pEBV-DNA level, maximal standard uptake value (SUVmax), and surgical outcome was analyzed. Results Forty-two patients had local tumor recurrence. Their median pEBV-DNA level and SUVmax were 348 copies and 4.7, respectively. Both values were significantly lower than those with palliative nasopharyngectomy. Twenty-two patients had regional failure. Their mean pEBV-DNA level and tumor SUVmax were 626 copies and 7.6, respectively. The metastatic lymph nodes with extracapsular spread had a significantly higher mean SUVmax. Conclusions Preoperative pEBV-DNA and PET-CT predict the surgical outcome of nasopharyngectomy for recurrent NPC. Similarly, PET-CT scan predicts the presence of extracapsular spread of metastatic lymph nodes. These patients may warrant further postoperative adjuvant therapy. Copyright © 2011 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.rightsHead & Neck: journal for the sciences and specialities of the head and neck. Copyright © John Wiley & Sons, Inc.-
dc.subject18F-FDG PET-CT scanen_HK
dc.subjectlymph node metastasisen_HK
dc.subjectmaxillary swing operationen_HK
dc.subjectpEBV-DNAen_HK
dc.subjectrecurrent nasopharyngeal carcinomaen_HK
dc.titlePrediction of surgical outcome using plasma epstein-barr virus dna and 18F-FDG PET-CT scan in recurrent nasopharyngeal carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1043-3074&volume=[Epub ahead of print]&spage=&epage=&date=2011&atitle=Prediction+of+surgical+outcome+using+plasma+epstein-barr+virus+DNA+and+(18)F-FDG+PET+scan+in+recurrent+nasopharyngeal+carcinoma-
dc.identifier.emailChan, JYW: jywchan1@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityChan, JYW=rp01314en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.21768en_HK
dc.identifier.pmid21523844-
dc.identifier.scopuseid_2-s2.0-84858077016en_HK
dc.identifier.hkuros176174en_HK
dc.identifier.hkuros190788-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858077016&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue4en_HK
dc.identifier.spage541en_HK
dc.identifier.epage545en_HK
dc.identifier.eissn1097-0347-
dc.identifier.isiWOS:000300980800012-
dc.publisher.placeUnited Statesen_HK
dc.description.otherThe 4th World Congress of International Federation of Head and Neck Oncologic Societies (IFHNOS 2010), Seoul, Korea, 15-19 June 2010. In Head & Neck, 2012, v. 34 n. 4, p. 541-545-
dc.identifier.scopusauthoridChan, JYW=27171772200en_HK
dc.identifier.scopusauthoridChow, VLY=36807611300en_HK
dc.identifier.scopusauthoridMok, VWK=23467468700en_HK
dc.identifier.scopusauthoridHo, ACW=16202695800en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK

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