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Conference Paper: Long-term survival analysis of living donor liver transplantation for hepatocellular carcinoma across Milan criteria

TitleLong-term survival analysis of living donor liver transplantation for hepatocellular carcinoma across Milan criteria
Authors
KeywordsMedical sciences
Gastroenterology medical sciences
Surgery
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The 15th Annual International Congress of the International Liver Transplant Society (ILTS), New York, NY., 8-11 July 2009. In Liver Transplantation, 2010, v. 15 suppl. S7, p. S143, abstract no. P-84 How to Cite?
AbstractBACKGROUND: Due to the shortage of deceased liver donor, living donor liver transplantation (LDLT) is the main viable option of transplantation for hepatocellular carcinoma (HCC) in the East. There is limited data in the literature on the long-term survival outcome of LDLT for HCC across Milan criteria. AIM OF STUDY: To investigate the long-term survival outcome of LDLT for HCC across Milan criteria in a single center PATIENTS AND METHODS: A total of 83 patients who underwent LDLT for HCC were retrospectively analyzed. Patients with extrahepatic metastases, major vascular tumor invasion and diffuse HCC were excluded. Recurrence-free survival results were analyzed. Significant prognostic factors were identified using univariate and multivariate analyses. RESULTS: Thirty-three patients (39.8%) had HCC with pathological features exceeding Milan criteria. The median follow-up period was 46 months (22 months – 120 months). The perioperative outcomes were comparable between patients with tumors within and outside Milan criteria. The 1-year, 3-year and 5-year recurrence-free survival rates for patients within Milan criteria were 93%, 78% and 72%, whereas those for patients beyond Milan criteria were 90%, 70% and 60%. There was no statistically significant difference between two groups. Microvascular tumor invasion was the independent poor prognostic factor for recurrence-free survival, whereas liver tumor status beyond Milan criteria posed no influence on patients’ survival. CONCLUSION: LDLT for HCC exceeding Milan criteria is associated with acceptable overall and recurrence-free survival rates. More clinical prospective date is necessary to justify the expansion of selection criteria beyond Milan criteria of LDLT for HCC.
DescriptionThis journal supplement is proceedings of the ILTS 15th Annual International Congress 2009
Poster Presentation: abstract no. P-84
Persistent Identifierhttp://hdl.handle.net/10722/126943
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorNg, KKCen_HK
dc.contributor.authorLo, CMen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2010-10-31T12:57:29Z-
dc.date.available2010-10-31T12:57:29Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 15th Annual International Congress of the International Liver Transplant Society (ILTS), New York, NY., 8-11 July 2009. In Liver Transplantation, 2010, v. 15 suppl. S7, p. S143, abstract no. P-84en_HK
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/126943-
dc.descriptionThis journal supplement is proceedings of the ILTS 15th Annual International Congress 2009-
dc.descriptionPoster Presentation: abstract no. P-84-
dc.description.abstractBACKGROUND: Due to the shortage of deceased liver donor, living donor liver transplantation (LDLT) is the main viable option of transplantation for hepatocellular carcinoma (HCC) in the East. There is limited data in the literature on the long-term survival outcome of LDLT for HCC across Milan criteria. AIM OF STUDY: To investigate the long-term survival outcome of LDLT for HCC across Milan criteria in a single center PATIENTS AND METHODS: A total of 83 patients who underwent LDLT for HCC were retrospectively analyzed. Patients with extrahepatic metastases, major vascular tumor invasion and diffuse HCC were excluded. Recurrence-free survival results were analyzed. Significant prognostic factors were identified using univariate and multivariate analyses. RESULTS: Thirty-three patients (39.8%) had HCC with pathological features exceeding Milan criteria. The median follow-up period was 46 months (22 months – 120 months). The perioperative outcomes were comparable between patients with tumors within and outside Milan criteria. The 1-year, 3-year and 5-year recurrence-free survival rates for patients within Milan criteria were 93%, 78% and 72%, whereas those for patients beyond Milan criteria were 90%, 70% and 60%. There was no statistically significant difference between two groups. Microvascular tumor invasion was the independent poor prognostic factor for recurrence-free survival, whereas liver tumor status beyond Milan criteria posed no influence on patients’ survival. CONCLUSION: LDLT for HCC exceeding Milan criteria is associated with acceptable overall and recurrence-free survival rates. More clinical prospective date is necessary to justify the expansion of selection criteria beyond Milan criteria of LDLT for HCC.-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantation-
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.subjectMedical sciences-
dc.subjectGastroenterology medical sciences-
dc.subjectSurgery-
dc.titleLong-term survival analysis of living donor liver transplantation for hepatocellular carcinoma across Milan criteriaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailNg, KKC: kkcng@hkucc.hku.hken_HK
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.authorityLo, CM=rp00412en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/lt.21830-
dc.identifier.hkuros162029en_HK
dc.identifier.hkuros170127-
dc.identifier.hkuros180778-
dc.identifier.volume15-
dc.identifier.issuesuppl. S7-
dc.identifier.spageS143-
dc.identifier.epageS143-
dc.publisher.placeUnited States-
dc.description.otherThe 15th Annual International Congress of the International Liver Transplant Society (ILTS), New York, NY., 8-11 July 2009. In Liver Transplantation, 2010, v. 15 suppl. S7, p. S143, abstract no. P-84-

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