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Conference Paper: Prognostic value of lymph node ratio in stage III colorectal cancer

TitlePrognostic value of lymph node ratio in stage III colorectal cancer
Authors
KeywordsColorectal cancer
Lymph node ratio
Survival
Issue Date2011
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CDI
Citation
The 2010 Annual Meeting of the American Society of Colon and Rectal Surgeons (ASCRS), Minneapolis, MN., 15-19 May 2010. In Colorectal Disease, 2011, v. 13, p. 1116–1122 How to Cite?
AbstractAim: Recent reports show that a positive metastatic to examined lymph nodes ratio (LNR) has prognostic value in malignancies. This study aimed to evaluate the prognostic value of LNR in patients having resection for stage III colorectal cancer. Method: From January 2000 to December 2006, patients who underwent resection for stage III colorectal carcinoma were included. All clinicopathological and follow-up data were prospectively collected. The impact of LNR and other clinicopathological factors on survival were evaluated. Results: The study included 533 (52.3% male) patients with a median age of 70years. The median number of lymph nodes harvested and the median number of positive lymph nodes examined were 11 and 2, respectively. The median LNR was 0.263 (range, 0.03-1). After a median follow up of 52.65months, the 5-year overall survival and disease-free survival were 55.9% and 49.4%. The patients were stratified into four groups according to LNR quartiles (1, LNR≤0.125; 2, 0.125< LNR≤ 0.263; 3, 0.263 0.500). The 5-year overall and disease-free survival were 72.8%, 63.1%, 50.0%, 39.6% (P<0.001) and 68.5%, 54.1%, 47.2%, 29.9% (P<0.001), respectively, with increasing LNR groups. On multivariate analysis, age, T stage and LNR were independent predictors of both overall and disease-free survival. Subgroup analysis revealed that the LNR had a prognostic value for disease-free survival irrespective of number of lymph nodes harvested and location of tumour. Conclusion: The LNR is an independent prognostic factor for survival in colorectal cancer and is superior to the pN category in TNM staging. © 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland.
Persistent Identifierhttp://hdl.handle.net/10722/126912
ISSN
2015 Impact Factor: 2.452
2015 SCImago Journal Rankings: 1.319
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KPen_HK
dc.contributor.authorPoon, JTCen_HK
dc.contributor.authorFan, JKMen_HK
dc.contributor.authorLaw, WLen_HK
dc.date.accessioned2010-10-31T12:55:47Z-
dc.date.available2010-10-31T12:55:47Z-
dc.date.issued2011en_HK
dc.identifier.citationThe 2010 Annual Meeting of the American Society of Colon and Rectal Surgeons (ASCRS), Minneapolis, MN., 15-19 May 2010. In Colorectal Disease, 2011, v. 13, p. 1116–1122en_HK
dc.identifier.issn1462-8910en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126912-
dc.description.abstractAim: Recent reports show that a positive metastatic to examined lymph nodes ratio (LNR) has prognostic value in malignancies. This study aimed to evaluate the prognostic value of LNR in patients having resection for stage III colorectal cancer. Method: From January 2000 to December 2006, patients who underwent resection for stage III colorectal carcinoma were included. All clinicopathological and follow-up data were prospectively collected. The impact of LNR and other clinicopathological factors on survival were evaluated. Results: The study included 533 (52.3% male) patients with a median age of 70years. The median number of lymph nodes harvested and the median number of positive lymph nodes examined were 11 and 2, respectively. The median LNR was 0.263 (range, 0.03-1). After a median follow up of 52.65months, the 5-year overall survival and disease-free survival were 55.9% and 49.4%. The patients were stratified into four groups according to LNR quartiles (1, LNR≤0.125; 2, 0.125< LNR≤ 0.263; 3, 0.263<LNR≤0.500; 4, LNR> 0.500). The 5-year overall and disease-free survival were 72.8%, 63.1%, 50.0%, 39.6% (P<0.001) and 68.5%, 54.1%, 47.2%, 29.9% (P<0.001), respectively, with increasing LNR groups. On multivariate analysis, age, T stage and LNR were independent predictors of both overall and disease-free survival. Subgroup analysis revealed that the LNR had a prognostic value for disease-free survival irrespective of number of lymph nodes harvested and location of tumour. Conclusion: The LNR is an independent prognostic factor for survival in colorectal cancer and is superior to the pN category in TNM staging. © 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CDIen_HK
dc.relation.ispartofColorectal Diseaseen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectColorectal canceren_HK
dc.subjectLymph node ratioen_HK
dc.subjectSurvivalen_HK
dc.titlePrognostic value of lymph node ratio in stage III colorectal canceren_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1462-8910&volume=Accepted Article&spage=&epage=&date=2010&atitle=Prognostic+value+of+lymph+node+ratio+in+stage+III+colorectal+cancer-
dc.identifier.emailPoon, JTC: tcjensen@hkucc.hku.hken_HK
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hken_HK
dc.identifier.authorityPoon, JTC=rp01603en_HK
dc.identifier.authorityLaw, WL=rp00436en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1463-1318.2010.02435.xen_HK
dc.identifier.pmid20874800-
dc.identifier.scopuseid_2-s2.0-80052749053en_HK
dc.identifier.hkuros175964en_HK
dc.identifier.hkuros192475-
dc.identifier.hkuros206851-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052749053&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1116en_HK
dc.identifier.epage1122en_HK
dc.identifier.isiWOS:000295084900015-
dc.publisher.placeUnited Kingdomen_HK
dc.description.otherAnnual Meeting of the American Society of Colon and Rectal Surgeons (ASCRS), Minneapolis, MN., 15-19 May 2010. In Colorectal Disease, 2011, v. 13, p. 1116–1122-
dc.identifier.scopusauthoridWong, KP=37125734900en_HK
dc.identifier.scopusauthoridPoon, JTC=7005903722en_HK
dc.identifier.scopusauthoridFan, JKM=23484820100en_HK
dc.identifier.scopusauthoridLaw, WL=7103147867en_HK
dc.customcontrol.immutablesml 160621 amended-

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