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Conference Paper: Female apolipoprotein E-deficient mice are protected against the development of endothelial dysfunction with ageing

TitleFemale apolipoprotein E-deficient mice are protected against the development of endothelial dysfunction with ageing
Authors
KeywordsPharmacy and pharmacology environmental studies
Toxicology and environmental safety
Issue Date2010
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PTO
Citation
The 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010. How to Cite?
AbstractEndothelial dysfunction is one of major factors leading to the development of atherosclerosis. Female animals are less susceptible to atherosclerosis. The present study investigated whether or not there is a gender difference in the degree of endothelial dysfunction during the development of atherosclerosis. Apolipoprotein E (ApoE)-deficient mouse is a well developed animal model in which atherosclerosis is established at about 24 weeks of age. Endothelium-dependent relaxations to acetylcholine were examined in aortae and superior mesenteric arteries isolated from ApoE-deficient mice of both genders at 8 and 32 weeks. Acetylcholine-induced nitric oxide (NO)-mediated relaxations in the aorta and mesenteric arteries were comparable in young male and female ApoE-deficient mice. In aged ApoE-deficient mice, the NO-mediated relaxations of the aorta and mesenteric arteries were reduced significantly only in the male gender. Similarly, the degree of endothelium-derived hyperpolarizing factors (EDHF)-mediated relaxations in mesenteric arteries of young ApoE-deficient mice was not different between male and female. However, the EDHF-mediated relaxation was abolished in aged male mice, but only partially reduced in aged female mice. Thus, the present findings indicate that during ageing female atherosclerotic-prone mice animals are protected from the impairment of both NO- and EDHFmediated relaxations. The better endothelial function in aged female ApoE-deficient mice may contribute to the protection against the development of atherosclerosis.
DescriptionBasic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl. 1, p. 148
Paper No. 2225 - Focused Conference Group: FC15 - Endothelium in Health and Disease
Persistent Identifierhttp://hdl.handle.net/10722/126890
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 0.539

 

DC FieldValueLanguage
dc.contributor.authorKong, WCBen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorVanhoutte, PMVen_HK
dc.contributor.authorLeung, SWSen_HK
dc.date.accessioned2010-10-31T12:54:30Z-
dc.date.available2010-10-31T12:54:30Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010.en_HK
dc.identifier.issn1742-7835-
dc.identifier.urihttp://hdl.handle.net/10722/126890-
dc.descriptionBasic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl. 1, p. 148-
dc.descriptionPaper No. 2225 - Focused Conference Group: FC15 - Endothelium in Health and Disease-
dc.description.abstractEndothelial dysfunction is one of major factors leading to the development of atherosclerosis. Female animals are less susceptible to atherosclerosis. The present study investigated whether or not there is a gender difference in the degree of endothelial dysfunction during the development of atherosclerosis. Apolipoprotein E (ApoE)-deficient mouse is a well developed animal model in which atherosclerosis is established at about 24 weeks of age. Endothelium-dependent relaxations to acetylcholine were examined in aortae and superior mesenteric arteries isolated from ApoE-deficient mice of both genders at 8 and 32 weeks. Acetylcholine-induced nitric oxide (NO)-mediated relaxations in the aorta and mesenteric arteries were comparable in young male and female ApoE-deficient mice. In aged ApoE-deficient mice, the NO-mediated relaxations of the aorta and mesenteric arteries were reduced significantly only in the male gender. Similarly, the degree of endothelium-derived hyperpolarizing factors (EDHF)-mediated relaxations in mesenteric arteries of young ApoE-deficient mice was not different between male and female. However, the EDHF-mediated relaxation was abolished in aged male mice, but only partially reduced in aged female mice. Thus, the present findings indicate that during ageing female atherosclerotic-prone mice animals are protected from the impairment of both NO- and EDHFmediated relaxations. The better endothelial function in aged female ApoE-deficient mice may contribute to the protection against the development of atherosclerosis.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PTO-
dc.relation.ispartofWorldPharma2010-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectPharmacy and pharmacology environmental studies-
dc.subjectToxicology and environmental safety-
dc.titleFemale apolipoprotein E-deficient mice are protected against the development of endothelial dysfunction with ageingen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-7835&volume=107, suppl. 1&spage=148&epage=&date=2010&atitle=Female+apolipoprotein+E-deficient+mice+are+protected+against+the+development+of+endothelial+dysfunction+with+ageing-
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.emailVanhoutte, PMV: vanhoutt@hku.hken_HK
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.hkuros172952en_HK
dc.identifier.volume107, suppl. 1-
dc.identifier.spage148-

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