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Conference Paper: Secretoneurin induces endothelium-dependent relaxation of the porcine coronary artery

TitleSecretoneurin induces endothelium-dependent relaxation of the porcine coronary artery
Authors
KeywordsPharmacy and pharmacology environmental studies
Toxicology and environmental safety
Issue Date2010
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PTO
Citation
The 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010. In Basic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl. 1, p. 222 How to Cite?
AbstractSecretoneurin is a part of the peptide encoded by the Secretogranin II gene. Secretoneurin enhances the adhesion and transendothelial migration properties of monocytes. In addition, in regenerated endothelium, the expression of the Secretogranin II gene is up-regulated. The objective of the present study was to examine the effects of Secretoneurin on the vascular reactivity. Isometric tension of rings with or without endothelium from porcine coronary arteries was measured in conventional organ chambers. Secretoneurin did not induce contraction, but in preparations contracted by the TP-receptor agonist U46619 it caused relaxation. This relaxation was endothelium-dependent and reduced by the nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME). It was abolished by combined incubation with L-NAME and the cyclooxygenase inhibitor indomethacin. By contrast the relaxation to secretoneurin was not affected by TRAM 34 and UCL 1684. These results suggest that secretoneurin induces relaxation by activation of both endothelial nitric oxide synthase and cyclooxygenase, with the nitric oxide pathway playing a more dominant role.
DescriptionFocused Conference Group: P15 – Endotheliumin Health and Disease. Paper No. 2224
Persistent Identifierhttp://hdl.handle.net/10722/126889
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 0.539

 

DC FieldValueLanguage
dc.contributor.authorChan, CKYen_HK
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.date.accessioned2010-10-31T12:54:27Z-
dc.date.available2010-10-31T12:54:27Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010. In Basic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl. 1, p. 222en_HK
dc.identifier.issn1742-7835-
dc.identifier.urihttp://hdl.handle.net/10722/126889-
dc.descriptionFocused Conference Group: P15 – Endotheliumin Health and Disease. Paper No. 2224-
dc.description.abstractSecretoneurin is a part of the peptide encoded by the Secretogranin II gene. Secretoneurin enhances the adhesion and transendothelial migration properties of monocytes. In addition, in regenerated endothelium, the expression of the Secretogranin II gene is up-regulated. The objective of the present study was to examine the effects of Secretoneurin on the vascular reactivity. Isometric tension of rings with or without endothelium from porcine coronary arteries was measured in conventional organ chambers. Secretoneurin did not induce contraction, but in preparations contracted by the TP-receptor agonist U46619 it caused relaxation. This relaxation was endothelium-dependent and reduced by the nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME). It was abolished by combined incubation with L-NAME and the cyclooxygenase inhibitor indomethacin. By contrast the relaxation to secretoneurin was not affected by TRAM 34 and UCL 1684. These results suggest that secretoneurin induces relaxation by activation of both endothelial nitric oxide synthase and cyclooxygenase, with the nitric oxide pathway playing a more dominant role.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PTO-
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectPharmacy and pharmacology environmental studies-
dc.subjectToxicology and environmental safety-
dc.titleSecretoneurin induces endothelium-dependent relaxation of the porcine coronary arteryen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-7835&volume=107, suppl. 1&spage=222&epage=&date=2010&atitle=Secretoneurin+induces+endothelium-dependent+relaxation+of+the+porcine+coronary+artery-
dc.identifier.emailChan, CKY: chancalvink@gmail.comen_HK
dc.identifier.emailMak, JCW: judymak@HKUCC.hku.hken_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.hkuros175327en_HK
dc.identifier.volume107, suppl. 1en_HK
dc.identifier.spage222en_HK
dc.identifier.epage222-
dc.description.otherThe 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010. In Basic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl. 1, p. 222-

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