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Conference Paper: Long-term administration of rutin, a dietary flavonoid, increases the hypotensive actions of acetylcholine in spontaneously hypertensive rats

TitleLong-term administration of rutin, a dietary flavonoid, increases the hypotensive actions of acetylcholine in spontaneously hypertensive rats
Authors
KeywordsBiology
Physiology medical sciences
Issue Date2010
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1748-1708
Citation
The 12th Symposium on Vascular Neuroeffector Mechanisms, Odense, Denmark, 24-26 July 2010. In Acta Physiologica, 2010, v. 199, suppl. 680, abstract no. 25 How to Cite?
AbstractFlavonoids are polyphenolic compounds that exist widely in the plant kingdom. Epidemiological reports have demonstrated an association between high dietary intake of flavonoids and lower incidence of heart diseases. Among the daily intake of flavonoids, about 60–75% is quercetin. Quercetin presents in fruits and vegetables mainly as glycosides such as rutin. The present study aimed to examine the effect of long-term oral administration of rutin on blood pressure in rats with and without hypertension. Male spontaneously hypertensive rats (SHR) and their normotensive controls, male Wistar Kyoto rats (WKY) were treated with rutin (10 mg/kg) or its vehicle (sodium carboxyl methyl cellulose, 1%/kg) for 14 days. They were then anaesthetized for the measurement of blood pressure with or without intravenous injections of phenylephrine (1.25, 2.5, 5 and 10 mg/kg) and acetylcholine (0.25, 0.5, 1 and 2 mg/kg). Rutin treatment did not change the blood pressure in both WKY and SHR. Phenylephrine concentration-dependently increased blood pressure and these increases were comparable in WKY and SHR, with and without rutin treatments. On the other hand, acetylcholine significantly decreased blood pressure in a concentration-dependent manner, and these hypotensive effects were greater in WKY than in SHR. Rutin treatment restored the hypotensive effects of acetylcholine in SHR. Therefore, the present findings suggest that long-term rutin treatment does not affect normal blood pressure regulation but enhances the vasodilatory effect of acetylcholine only in hypertensive rats.
Persistent Identifierhttp://hdl.handle.net/10722/126886
ISSN
2015 Impact Factor: 4.066
2015 SCImago Journal Rankings: 1.690

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorMan, GSKen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-10-31T12:54:17Z-
dc.date.available2010-10-31T12:54:17Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 12th Symposium on Vascular Neuroeffector Mechanisms, Odense, Denmark, 24-26 July 2010. In Acta Physiologica, 2010, v. 199, suppl. 680, abstract no. 25en_HK
dc.identifier.issn1748-1708-
dc.identifier.urihttp://hdl.handle.net/10722/126886-
dc.description.abstractFlavonoids are polyphenolic compounds that exist widely in the plant kingdom. Epidemiological reports have demonstrated an association between high dietary intake of flavonoids and lower incidence of heart diseases. Among the daily intake of flavonoids, about 60–75% is quercetin. Quercetin presents in fruits and vegetables mainly as glycosides such as rutin. The present study aimed to examine the effect of long-term oral administration of rutin on blood pressure in rats with and without hypertension. Male spontaneously hypertensive rats (SHR) and their normotensive controls, male Wistar Kyoto rats (WKY) were treated with rutin (10 mg/kg) or its vehicle (sodium carboxyl methyl cellulose, 1%/kg) for 14 days. They were then anaesthetized for the measurement of blood pressure with or without intravenous injections of phenylephrine (1.25, 2.5, 5 and 10 mg/kg) and acetylcholine (0.25, 0.5, 1 and 2 mg/kg). Rutin treatment did not change the blood pressure in both WKY and SHR. Phenylephrine concentration-dependently increased blood pressure and these increases were comparable in WKY and SHR, with and without rutin treatments. On the other hand, acetylcholine significantly decreased blood pressure in a concentration-dependent manner, and these hypotensive effects were greater in WKY than in SHR. Rutin treatment restored the hypotensive effects of acetylcholine in SHR. Therefore, the present findings suggest that long-term rutin treatment does not affect normal blood pressure regulation but enhances the vasodilatory effect of acetylcholine only in hypertensive rats.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1748-1708-
dc.relation.ispartofActa Physiologica-
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectBiology-
dc.subjectPhysiology medical sciences-
dc.titleLong-term administration of rutin, a dietary flavonoid, increases the hypotensive actions of acetylcholine in spontaneously hypertensive ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1748-1708&volume=199, suppl. 680, abstract no. 25&spage=&epage=&date=2010&atitle=Long-term+administration+of+rutin,+a+dietary+flavonoid,+increases+the+hypotensive+actions+of+acetylcholine+in+spontaneously+hypertensive+rats-
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.emailMan, GSK: gskman@HKUSUA.hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.hkuros172956en_HK
dc.identifier.volume199-
dc.description.otherThe 12th Symposium on Vascular Neuroeffector Mechanisms, Odense, Denmark, 24-26 July 2010. In Acta Physiologica, 2010, v. 199, suppl. 680, abstract no. 25-

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