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Conference Paper: Modulation of vascular reactivity by kaempferol in porcine coronary arteries

TitleModulation of vascular reactivity by kaempferol in porcine coronary arteries
Authors
KeywordsPharmacy and pharmacology environmental studies
Toxicology and environmental safety
Issue Date2010
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PTO
Citation
The 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010. How to Cite?
AbstractKaempferol is one of the major bioactive components of the Chinese herbal medicine, Carthamus tinctorius, which has long been used for the management of various cardiovascular diseases. The present study aimed to examine the vascular effects of kaempferol and to investigate the mechanism through which kaempferol modulated vascular reactivity. In the presence of indomethacin, kaempferol directly relaxed porcine coronary arteries with and without endothelium at high concentrations. At lower concentration, kaempferol reduced contractions to the depolarizing agent potassium chloride and the thromboxane A2 analogue U46619, and poten- tiated relaxation to SNP. The potentiating effect of kaempferol on SNPinduced relaxation was partially inhibited by the big conductance calciumactivated potassium channel (BKCa) blocker, iberiotoxin, but not by the selective intermediate conductance calcium-activated potassium (KCa) channel blocker TRAM-34 and small conductance KCa channel blocker UCL-1684, in porcine coronary arteries with and without endothelium. On the other hand, iberiotoxin did not affect the inhibitory effect of kaempferol on contractions. The big and intermediate conductance KCa channel blocker charybdotoxin or the protein kinase A blocker KT5720 were also without effect. Neither iberiotoxin, charybdotoxin, KT5720 nor the nitric oxide synthase inhibitor L-NAME affected the direct relaxation of high concentrations of kaempferol. These findings suggest that kaempferol potentiates relaxation to SNP partly through activation of big conductance KCa channels in vascular smooth muscle. However, other mechanisms are involved in the direct relaxation effect and the inhibitory effect on contraction of kaempferol in porcine coronary arteries.
DescriptionBasic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl.1, p. 695-696
Paper No. 2175 - Focus Group: FC16 - Natural Products: Past and Future?
Persistent Identifierhttp://hdl.handle.net/10722/126881
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 0.539

 

DC FieldValueLanguage
dc.contributor.authorLau, YTen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-10-31T12:54:01Z-
dc.date.available2010-10-31T12:54:01Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010.en_HK
dc.identifier.issn1742-7835-
dc.identifier.urihttp://hdl.handle.net/10722/126881-
dc.descriptionBasic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl.1, p. 695-696-
dc.descriptionPaper No. 2175 - Focus Group: FC16 - Natural Products: Past and Future?-
dc.description.abstractKaempferol is one of the major bioactive components of the Chinese herbal medicine, Carthamus tinctorius, which has long been used for the management of various cardiovascular diseases. The present study aimed to examine the vascular effects of kaempferol and to investigate the mechanism through which kaempferol modulated vascular reactivity. In the presence of indomethacin, kaempferol directly relaxed porcine coronary arteries with and without endothelium at high concentrations. At lower concentration, kaempferol reduced contractions to the depolarizing agent potassium chloride and the thromboxane A2 analogue U46619, and poten- tiated relaxation to SNP. The potentiating effect of kaempferol on SNPinduced relaxation was partially inhibited by the big conductance calciumactivated potassium channel (BKCa) blocker, iberiotoxin, but not by the selective intermediate conductance calcium-activated potassium (KCa) channel blocker TRAM-34 and small conductance KCa channel blocker UCL-1684, in porcine coronary arteries with and without endothelium. On the other hand, iberiotoxin did not affect the inhibitory effect of kaempferol on contractions. The big and intermediate conductance KCa channel blocker charybdotoxin or the protein kinase A blocker KT5720 were also without effect. Neither iberiotoxin, charybdotoxin, KT5720 nor the nitric oxide synthase inhibitor L-NAME affected the direct relaxation of high concentrations of kaempferol. These findings suggest that kaempferol potentiates relaxation to SNP partly through activation of big conductance KCa channels in vascular smooth muscle. However, other mechanisms are involved in the direct relaxation effect and the inhibitory effect on contraction of kaempferol in porcine coronary arteries.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PTO-
dc.relation.ispartofWorldPharma2010en_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectPharmacy and pharmacology environmental studies-
dc.subjectToxicology and environmental safety-
dc.titleModulation of vascular reactivity by kaempferol in porcine coronary arteriesen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-7835&volume=107, suppl.1&spage=695&epage=696&date=2010&atitle=Modulation+of+vascular+reactivity+by+kaempferol+in+porcine+coronary+arteries-
dc.identifier.emailLau, YT: matthew.1110@hotmail.comen_HK
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.hkuros175346en_HK
dc.identifier.volume107, suppl.1en_HK
dc.identifier.spage695en_HK
dc.identifier.epage696en_HK

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