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Conference Paper: Beneficial vascular effect of a non-selective PPAR activator in aorta of spontaneously hypertensive rats

TitleBeneficial vascular effect of a non-selective PPAR activator in aorta of spontaneously hypertensive rats
Authors
KeywordsBiology
Issue Date2010
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The ASIP Annual Meeting at Experimental Biology (EB 2010), Anaheim, CA., 24-28 April 2010. In The FASEB Journal, 2010, v. 24 meeting abstracts, abstract no. 955.10 How to Cite?
AbstractWy14643 is a potent activator of peroxisome proliferator-activated receptor (PPAR)alpha and gamma. The present study aimed to determine whether or not Wy14643 improved endothelial dysfunction in hypertension, and if so, the mechanism involved. Isometric tension in isolated thoracic aortic rings of spontaneously hypertensive rats was recorded. Wy14643 caused greater relaxations than fenofibrate (PPAR alpha activator) or rosiglitazone (PPAR gamma activator). L-NAME (nitric oxide synthase inhibitor) and ODQ (soluble guanylyl cyclase inhibitor) alone and in combination inhibited these relaxations to the same extent. Compound C (AMP-activated protein kinase (AMPK) inhibitor) reduced Wy14643-induced relaxations to the same extent as L-NAME. Endothelium-dependent contractions evoked by acetylcholine in the presence of L-NAME were reduced by Wy14643, fenofibrate but not rosiglitazone. Moreover, Wy14643 and fenofibrate inhibited acetylcholine-induced prostanoids release to the same extent. Our data suggests that the three PPAR activators induce nitric oxide-mediated relaxation through activation of AMPK. This relaxing effect is more prominent with Wy14643. Together with the ability to reduce the release of endothelium-dependent contracting factor, it appears that Wy14643 produces better protection against vascular diseases in spontaneous hypertension.
DescriptionOpen Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/126876
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorQu, Cen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-10-31T12:53:44Z-
dc.date.available2010-10-31T12:53:44Z-
dc.date.issued2010en_HK
dc.identifier.citationThe ASIP Annual Meeting at Experimental Biology (EB 2010), Anaheim, CA., 24-28 April 2010. In The FASEB Journal, 2010, v. 24 meeting abstracts, abstract no. 955.10en_HK
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/126876-
dc.descriptionOpen Access Journal-
dc.description.abstractWy14643 is a potent activator of peroxisome proliferator-activated receptor (PPAR)alpha and gamma. The present study aimed to determine whether or not Wy14643 improved endothelial dysfunction in hypertension, and if so, the mechanism involved. Isometric tension in isolated thoracic aortic rings of spontaneously hypertensive rats was recorded. Wy14643 caused greater relaxations than fenofibrate (PPAR alpha activator) or rosiglitazone (PPAR gamma activator). L-NAME (nitric oxide synthase inhibitor) and ODQ (soluble guanylyl cyclase inhibitor) alone and in combination inhibited these relaxations to the same extent. Compound C (AMP-activated protein kinase (AMPK) inhibitor) reduced Wy14643-induced relaxations to the same extent as L-NAME. Endothelium-dependent contractions evoked by acetylcholine in the presence of L-NAME were reduced by Wy14643, fenofibrate but not rosiglitazone. Moreover, Wy14643 and fenofibrate inhibited acetylcholine-induced prostanoids release to the same extent. Our data suggests that the three PPAR activators induce nitric oxide-mediated relaxation through activation of AMPK. This relaxing effect is more prominent with Wy14643. Together with the ability to reduce the release of endothelium-dependent contracting factor, it appears that Wy14643 produces better protection against vascular diseases in spontaneous hypertension.-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journal-
dc.subjectBiology-
dc.titleBeneficial vascular effect of a non-selective PPAR activator in aorta of spontaneously hypertensive ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0892-6638&volume=24&issue=Meeting Abstracts, abstract no. 955.10&spage=&epage=&date=2010&atitle=Beneficial+vascular+effect+of+a+non-selective+PPAR+activator+in+aorta+of+spontaneously+hypertensive+rats-
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros172950en_HK
dc.identifier.volume24-
dc.identifier.issuemeeting abstracts-
dc.description.otherThe ASIP Annual Meeting at Experimental Biology (EB 2010), Anaheim, CA., 24-28 April 2010. In The FASEB Journal, 2010, v. 24 meeting abstracts, abstract no. 955.10-

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