File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL

Conference Paper: Ruboxistaurin attenuates hypertriglyceridemia in diabetic rats: comparison with the antioxidant N-acetylcysteine

TitleRuboxistaurin attenuates hypertriglyceridemia in diabetic rats: comparison with the antioxidant N-acetylcysteine
Authors
KeywordsBiology
Issue Date2010
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The 2010 Annual Meeting of Experimental Biology (EB 2010), Anaheim, CA., 24-28 April 2010. In The FASEB Journal, v. 24, Meeting abstract suppl., abstract no. 572.5 How to Cite?
AbstractHyperglycemia-induced oxidative stress plays a critical role in the development of diabetic metabolic complications including hypertriglyceridemia. The beta isoform of Protein kinase C (PKCβ) is over-expressed in various organs of diabetic rodents and can cause or exacerbate oxidative stress by activating NADPH oxidase, a major source of superoxide production in the cardiovascular system. We postulated that selective PKCβ inhibition with ruboxistaurin (RXT) may attenuate hypertriglyceridemia in diabetes by reducing oxidative stress. Control or streptozotozin-induced diabetic rats were either untreated (C, D) or treated with RXT (1 mg/kg/day, D+RXT) or with the antioxidant N-acetylcycsteine (NAC) (1.5g/kg/day, D+NAC) delivered by oral gavage for four weeks. Levels of 15-F2t-isoprostane (IsoP), a specific marker of oxidative stress, were significantly increased in D group in both the myocardium and plasma. This was accompanied by a marked increase in plasma triglycerides (P<0.05 vs. C). RXT and NAC, respectively, prevented the increase of IsoP and significantly attenuated the increases of triglycerides. However, triglycerides in the D+NAC group was lowered further than that in the D+RXT group (P<0.05). Despite similar antioxidant properties, ruboxistaurin seems to be inferior to NAC in reducing hypertriglyceridemia in diabetes.
DescriptionOpen Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/126873
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorLei, Sen_HK
dc.contributor.authorLiu, HMen_HK
dc.contributor.authorMao, Xen_HK
dc.contributor.authorWong, GTCen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorXia, Z-
dc.date.accessioned2010-10-31T12:53:35Z-
dc.date.available2010-10-31T12:53:35Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 2010 Annual Meeting of Experimental Biology (EB 2010), Anaheim, CA., 24-28 April 2010. In The FASEB Journal, v. 24, Meeting abstract suppl., abstract no. 572.5en_HK
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/126873-
dc.descriptionOpen Access Journal-
dc.description.abstractHyperglycemia-induced oxidative stress plays a critical role in the development of diabetic metabolic complications including hypertriglyceridemia. The beta isoform of Protein kinase C (PKCβ) is over-expressed in various organs of diabetic rodents and can cause or exacerbate oxidative stress by activating NADPH oxidase, a major source of superoxide production in the cardiovascular system. We postulated that selective PKCβ inhibition with ruboxistaurin (RXT) may attenuate hypertriglyceridemia in diabetes by reducing oxidative stress. Control or streptozotozin-induced diabetic rats were either untreated (C, D) or treated with RXT (1 mg/kg/day, D+RXT) or with the antioxidant N-acetylcycsteine (NAC) (1.5g/kg/day, D+NAC) delivered by oral gavage for four weeks. Levels of 15-F2t-isoprostane (IsoP), a specific marker of oxidative stress, were significantly increased in D group in both the myocardium and plasma. This was accompanied by a marked increase in plasma triglycerides (P<0.05 vs. C). RXT and NAC, respectively, prevented the increase of IsoP and significantly attenuated the increases of triglycerides. However, triglycerides in the D+NAC group was lowered further than that in the D+RXT group (P<0.05). Despite similar antioxidant properties, ruboxistaurin seems to be inferior to NAC in reducing hypertriglyceridemia in diabetes.-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_HK
dc.subjectBiology-
dc.titleRuboxistaurin attenuates hypertriglyceridemia in diabetic rats: comparison with the antioxidant N-acetylcysteineen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0892-6638&volume=24, Meeting Abstract Suppl. 572.5 &spage=&epage=&date=2010&atitle=Ruboxistaurin+attenuates+hypertriglyceridemia+in+diabetic+rats:+comparison+with+the+antioxidant+N-acetylcysteine-
dc.identifier.emailLei, S: leishaoqing@163.comen_HK
dc.identifier.emailLiu, HM: huimin_liu2006@126.comen_HK
dc.identifier.emailWong, GTC: gordon@hku.hken_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.emailIrwin, MG: mgirwin@hkucc.hku.hken_HK
dc.identifier.emailXia, Z: zhengyuan_xia@yahoo.com-
dc.identifier.authorityWong, GTC=rp00523en_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros171205en_HK
dc.identifier.volume24en_HK
dc.identifier.issueMeeting abstract suppl.-
dc.description.otherExperimental Biology Annual Meeting (EB 2010), Anaheim, CA., 24-28 April 2010. In The FASEB Journal, v. 24, Meeting abstract suppl., abstract no. 572.5-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats