File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Vascular effects of protease inhibitors and non-nucleoside reverse transcriptase inhibitors, the major components of highly active antiretroviral therapy [HAART]

TitleVascular effects of protease inhibitors and non-nucleoside reverse transcriptase inhibitors, the major components of highly active antiretroviral therapy [HAART]
Authors
KeywordsPharmacy and pharmacology environmental studies
Toxicology and environmental safety
Issue Date2010
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PTO
Citation
The 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010. In Basic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl. 1, p. 674 How to Cite?
AbstractThe number of patients with human immunodeficiency virus (HIV) infection increase every year worldwide. Highly active antiretroviral therapy (HAART), including protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), has shown promise for the treatment of HIV. However, previous experimental studies suggest that certain PIs affect vascular regulation, leading to the development of cardiovascular disease (CVD), which becomes one of the major causes of morbidity and mortality in HIV-infected patients. Therefore, it is possible that HAART imposes adverse effects on vascular reactivity. The present study was designed to study the acute effects of various clinically used PIs (indinavir, lopinavir, nelfinavir, ritonavir, saquinavir and tipranavir) and NNRTIs (efavirenz and nevirapine) on isolated rat mesenteric arteries suspended in organ chambers for the measurement of isometric force. Among the antiretroviral drugs tested, all PIs and NNRTIs, except nevirapine, caused full relaxation of mesenteric arteries during contractions to phenylephrine. These relaxations were not affected by the presence of nitro-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthases. The present data suggested that most clinically used PIs and NNRTIs relax mesenteric arteries by activating a signalling pathway that is independent of the release of nitric oxide. Since the relaxation occurred when the antiretroviral drugs are present at high concentrations, care should be taken with the prescription of high doses of these drugs to avoid unwanted vasodilatation.
DescriptionPaper no. 1653 - Focused Conference Group: P13 - Maximising Bebefits and Minimizing Harms from Drugs
Persistent Identifierhttp://hdl.handle.net/10722/126871
ISSN
2015 Impact Factor: 3.097
2015 SCImago Journal Rankings: 0.539

 

DC FieldValueLanguage
dc.contributor.authorYeung, YTen_HK
dc.contributor.authorLee, SSen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorLeung, SWSen_HK
dc.date.accessioned2010-10-31T12:53:28Z-
dc.date.available2010-10-31T12:53:28Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010. In Basic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl. 1, p. 674en_HK
dc.identifier.issn1742-7835-
dc.identifier.urihttp://hdl.handle.net/10722/126871-
dc.descriptionPaper no. 1653 - Focused Conference Group: P13 - Maximising Bebefits and Minimizing Harms from Drugs-
dc.description.abstractThe number of patients with human immunodeficiency virus (HIV) infection increase every year worldwide. Highly active antiretroviral therapy (HAART), including protease inhibitors (PIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), has shown promise for the treatment of HIV. However, previous experimental studies suggest that certain PIs affect vascular regulation, leading to the development of cardiovascular disease (CVD), which becomes one of the major causes of morbidity and mortality in HIV-infected patients. Therefore, it is possible that HAART imposes adverse effects on vascular reactivity. The present study was designed to study the acute effects of various clinically used PIs (indinavir, lopinavir, nelfinavir, ritonavir, saquinavir and tipranavir) and NNRTIs (efavirenz and nevirapine) on isolated rat mesenteric arteries suspended in organ chambers for the measurement of isometric force. Among the antiretroviral drugs tested, all PIs and NNRTIs, except nevirapine, caused full relaxation of mesenteric arteries during contractions to phenylephrine. These relaxations were not affected by the presence of nitro-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthases. The present data suggested that most clinically used PIs and NNRTIs relax mesenteric arteries by activating a signalling pathway that is independent of the release of nitric oxide. Since the relaxation occurred when the antiretroviral drugs are present at high concentrations, care should be taken with the prescription of high doses of these drugs to avoid unwanted vasodilatation.-
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PTO-
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectPharmacy and pharmacology environmental studies-
dc.subjectToxicology and environmental safety-
dc.titleVascular effects of protease inhibitors and non-nucleoside reverse transcriptase inhibitors, the major components of highly active antiretroviral therapy [HAART]en_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1742-7835&volume=107, suppl. 1&spage=674&epage=&date=2010&atitle=Vascular+effects+of+protease+inhibitors+and+non-nucleoside+reverse+transcriptase+inhibitors,+the+major+components+of+highly+active+antiretroviral+therapy+[HAART]-
dc.identifier.emailYeung, YT: yukiyeung1129@yahoo.com.hken_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.hkuros175342en_HK
dc.identifier.volume107en_HK
dc.identifier.issuesuppl. 1-
dc.identifier.spage674en_HK
dc.identifier.epage674-
dc.description.otherThe 16th World Congress on Basic and Clinical Pharmacology (WorldPharma2010), Copenhagen, Denmark, 17-23 July 2010. In Basic & Clinical Pharmacology & Toxicology, 2010, v. 107, suppl. 1, p. 674-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats