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Conference Paper: Characteristics & outcome of metastatic infant neuroblastoma

TitleCharacteristics & outcome of metastatic infant neuroblastoma
Authors
Issue Date2010
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Joint Annual Scientific Meeting of the Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, China, 28 November, 2009. In the Hong Kong Journal of Paediatrics (New series), 2010, v. 15 n. 1, p. 68 How to Cite?
AbstractBACKGROUND: Metastatic neuroblastoma in infancy behaved differently from those of older children. A significant proportion of them can regress spontaneously (stage 4S). The MYCN status, Shimada classification, DNA index & 11q rearrangement may affect the outcome and has been adopted as guidance for treatment stratification. We reviewed our experience on this cohort of patients. PATIENTS AND METHOD: This is a prospective cohort study. The patients were recruited from 5 regional hospitals which take care of all children with cancer locally. The data were collected by 2 data managers sponsored by Children Cancer Foundations. Infant was defined as patients ≤365-day-old. The staging was according to the INSS system. The presence of abnormal bone scan, MIBG scan in the skeletal area and distant lymphoid region will be classified as INSS stage 4. Treatments included POG low intensity chemotherapy protocol or high intensity regimens (modified from MSKCC or OPEC). MYCN was evaluated by FISH in the University Laboratory. RESULTS: From Jan 1993 to Dec 2006, a total of 13 patients were diagnosed and treated in the 5 centers (total 134 for all stages, 9.7%). There were 5 stage 4S patients, 4/5 received chemotherapy due to either rapidly enlarging tumors in their visceral organs or cord compression. There were 8 stage 4 patients, all received chemotherapy and 6 under intensive protocols. The median age was 0.28 yrs (range 0.08-0.57 yrs) for stage 4S and 0.7 yrs (range 0 - 0.84 yrs) for stage 4. None of the stage 4S and 30% of stage 4 tested had MYCN amplification. 4/5 stage 4S patients survived at a median follow-up of 8.6 yrs (0.1-11.8 yrs). The only mortality was due to hepatic rupture without prior chemotherapy. For stage 4 patients, 6/8 patients survived at a median follow up of 3.3 yrs (0.1-8.8 yrs). Both fatal cases died of disease progression and they don't have MYCN amplification. CONCLUSION: In our infant metastatic neuroblastoma cohort, stage 4 neuroblastoma was even more common than stage 4S. All of our survived stage 4S patients required treatment and their long term outcome was excellent. Our stage 4 patients also had better outcome than older children with stage 4 disease.
DescriptionProceedings of Congress: Oral Presentation (Doctor's Session)
Open Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/126829
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123

 

DC FieldValueLanguage
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorShing, MMKen_HK
dc.contributor.authorLuk, CWen_HK
dc.contributor.authorLi, RCHen_HK
dc.contributor.authorLing, SCen_HK
dc.contributor.authorLi, CKen_HK
dc.contributor.authorHa, SYen_HK
dc.date.accessioned2010-10-31T12:51:04Z-
dc.date.available2010-10-31T12:51:04Z-
dc.date.issued2010en_HK
dc.identifier.citationJoint Annual Scientific Meeting of the Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Hong Kong, China, 28 November, 2009. In the Hong Kong Journal of Paediatrics (New series), 2010, v. 15 n. 1, p. 68en_HK
dc.identifier.issn1013-9923-
dc.identifier.urihttp://hdl.handle.net/10722/126829-
dc.descriptionProceedings of Congress: Oral Presentation (Doctor's Session)-
dc.descriptionOpen Access Journal-
dc.description.abstractBACKGROUND: Metastatic neuroblastoma in infancy behaved differently from those of older children. A significant proportion of them can regress spontaneously (stage 4S). The MYCN status, Shimada classification, DNA index & 11q rearrangement may affect the outcome and has been adopted as guidance for treatment stratification. We reviewed our experience on this cohort of patients. PATIENTS AND METHOD: This is a prospective cohort study. The patients were recruited from 5 regional hospitals which take care of all children with cancer locally. The data were collected by 2 data managers sponsored by Children Cancer Foundations. Infant was defined as patients ≤365-day-old. The staging was according to the INSS system. The presence of abnormal bone scan, MIBG scan in the skeletal area and distant lymphoid region will be classified as INSS stage 4. Treatments included POG low intensity chemotherapy protocol or high intensity regimens (modified from MSKCC or OPEC). MYCN was evaluated by FISH in the University Laboratory. RESULTS: From Jan 1993 to Dec 2006, a total of 13 patients were diagnosed and treated in the 5 centers (total 134 for all stages, 9.7%). There were 5 stage 4S patients, 4/5 received chemotherapy due to either rapidly enlarging tumors in their visceral organs or cord compression. There were 8 stage 4 patients, all received chemotherapy and 6 under intensive protocols. The median age was 0.28 yrs (range 0.08-0.57 yrs) for stage 4S and 0.7 yrs (range 0 - 0.84 yrs) for stage 4. None of the stage 4S and 30% of stage 4 tested had MYCN amplification. 4/5 stage 4S patients survived at a median follow-up of 8.6 yrs (0.1-11.8 yrs). The only mortality was due to hepatic rupture without prior chemotherapy. For stage 4 patients, 6/8 patients survived at a median follow up of 3.3 yrs (0.1-8.8 yrs). Both fatal cases died of disease progression and they don't have MYCN amplification. CONCLUSION: In our infant metastatic neuroblastoma cohort, stage 4 neuroblastoma was even more common than stage 4S. All of our survived stage 4S patients required treatment and their long term outcome was excellent. Our stage 4 patients also had better outcome than older children with stage 4 disease.-
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp-
dc.relation.ispartofHong Kong Journal of Paediatrics (New series)-
dc.relation.ispartof香港兒科醫學雜誌-
dc.titleCharacteristics & outcome of metastatic infant neuroblastomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, GCF: gcfchan@hkucc.hku.hken_HK
dc.identifier.emailHa, SY: syha@hkucc.hku.hken_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros179124en_HK
dc.identifier.hkuros168351-
dc.identifier.volume15-
dc.identifier.issue1-
dc.identifier.spage68-
dc.identifier.epage68-
dc.publisher.placeHong Kong-
dc.customcontrol.immutablesml 130930-

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