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Conference Paper: Tumor suppressive and angiogenic role of THSD1 in esophageal squamous cell carcinoma and nasopharyngeal carcinoma

TitleTumor suppressive and angiogenic role of THSD1 in esophageal squamous cell carcinoma and nasopharyngeal carcinoma
Authors
Ko, JMYCheung, AKLLung, ML
Issue Date2010
PublisherAmerican Association for Cancer Research.
Citation
The 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010. How to Cite?
AbstractBACKGROUND AND AIMS: Loss of chromosome 13q regions is a frequent event in both esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). By microcell-mediated chromosome transfer, chromosome 13 was demonstrated to play a significant tumor suppressive role in both ESCC and NPC in our laboratory. THSD1 is a novel candidate tumor suppressor gene (TSG) previously identified by microarray differential gene expression profiling. It encodes a transmembrane molecule containing a thrombospondin type 1 repeat (TSR), which may be involved in cell adhesion and angiogenesis. Proteins possessing the TSR, such as thrombospondin-1 (Tsp1), ADAM metallopeptidase with thrombospondin type 1 motif, 1 (ADAMTS1) and ADAMTS8, regulate angiogenesis. We previously showed that the ...
DescriptionPoster Session 5 - Novel Tumor Suppressor Genes 1: abstract no. 3061
Persistent Identifierhttp://hdl.handle.net/10722/126824

 

DC FieldValueLanguage
dc.contributor.authorKo, JMYen_HK
dc.contributor.authorCheung, AKLen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2010-10-31T12:50:42Z-
dc.date.available2010-10-31T12:50:42Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126824-
dc.descriptionPoster Session 5 - Novel Tumor Suppressor Genes 1: abstract no. 3061-
dc.description.abstractBACKGROUND AND AIMS: Loss of chromosome 13q regions is a frequent event in both esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). By microcell-mediated chromosome transfer, chromosome 13 was demonstrated to play a significant tumor suppressive role in both ESCC and NPC in our laboratory. THSD1 is a novel candidate tumor suppressor gene (TSG) previously identified by microarray differential gene expression profiling. It encodes a transmembrane molecule containing a thrombospondin type 1 repeat (TSR), which may be involved in cell adhesion and angiogenesis. Proteins possessing the TSR, such as thrombospondin-1 (Tsp1), ADAM metallopeptidase with thrombospondin type 1 motif, 1 (ADAMTS1) and ADAMTS8, regulate angiogenesis. We previously showed that the ...-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research.-
dc.relation.ispartofAnnual Meeting of the American Association for Cancer Research, AACR 2010en_HK
dc.titleTumor suppressive and angiogenic role of THSD1 in esophageal squamous cell carcinoma and nasopharyngeal carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailKo, JMY: joko@hku.hken_HK
dc.identifier.emailCheung, AKL: arthurhk@hku.hken_HK
dc.identifier.emailLung, ML: mlilung@hku.hken_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros170979en_HK
dc.publisher.placeUnited States-
dc.description.otherThe 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010.-

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