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Conference Paper: Maturation profile of inhibitory and excitatory postsynaptic currents in central vestibular neurons of rats

TitleMaturation profile of inhibitory and excitatory postsynaptic currents in central vestibular neurons of rats
Authors
KeywordsVestibular
Development
Synaptic transmission
Issue Date2009
PublisherSociety for Neuroscience.
Citation
The 39th Annual Meeting of the Society for Neuroscience (SfN), Chicago, IL., 17-21 October 2009. How to Cite?
AbstractIn adult mammals, signal transmission within the vestibular nucleus is regulated by actions of inhibitory and excitatory synapses. Little is known about synaptic activities in the vestibular nucleus during postnatal development. Here we show the maturation profiles of synaptic connections within the spinal vestibular nucleus of Sprague-Dawley rats. Whole-cell patch-clamp recordings in brainstem slices revealed that GABAergic miniature inhibitory postsynaptic current (mIPSC) was observed from P1 onwards. The number and amplitude of mIPSC events increased while their decay time decreased with maturation. However, corresponding parameters of glutamatergic miniature excitatory postsynaptic current (mEPSC) did not change with development. These mEPSCs were equally contributed by AMPA and NMDA receptor-mediated currents before P9 but were dominated by the AMPA component at P21. While the rise and decay time of mEPSCs in both AMPA and NMDA components decreased from P5 to P7, no change was observed between P7 and P9. For EPSCs evoked by electrical stimulation of the vestibular nerve, predominance of the NMDA component was observed at P1. During the first two weeks of life, decline in NMDA receptor-mediated evoked-EPSCs is accompanied by increase in AMPA receptor-mediated evoked-EPSCs. Taken together, our findings document changes in inhibitory and excitatory synapses with regard to receptor utilization during the functional maturation of central vestibular neurons.
DescriptionPoster - 813 Development: Auditory and Vestibular Systems: abstract no. 813.14/B62
Persistent Identifierhttp://hdl.handle.net/10722/126735

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorTse, YCen_HK
dc.contributor.authorHu, Hen_HK
dc.contributor.authorWong, TPen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-10-31T12:45:31Z-
dc.date.available2010-10-31T12:45:31Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 39th Annual Meeting of the Society for Neuroscience (SfN), Chicago, IL., 17-21 October 2009.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126735-
dc.descriptionPoster - 813 Development: Auditory and Vestibular Systems: abstract no. 813.14/B62-
dc.description.abstractIn adult mammals, signal transmission within the vestibular nucleus is regulated by actions of inhibitory and excitatory synapses. Little is known about synaptic activities in the vestibular nucleus during postnatal development. Here we show the maturation profiles of synaptic connections within the spinal vestibular nucleus of Sprague-Dawley rats. Whole-cell patch-clamp recordings in brainstem slices revealed that GABAergic miniature inhibitory postsynaptic current (mIPSC) was observed from P1 onwards. The number and amplitude of mIPSC events increased while their decay time decreased with maturation. However, corresponding parameters of glutamatergic miniature excitatory postsynaptic current (mEPSC) did not change with development. These mEPSCs were equally contributed by AMPA and NMDA receptor-mediated currents before P9 but were dominated by the AMPA component at P21. While the rise and decay time of mEPSCs in both AMPA and NMDA components decreased from P5 to P7, no change was observed between P7 and P9. For EPSCs evoked by electrical stimulation of the vestibular nerve, predominance of the NMDA component was observed at P1. During the first two weeks of life, decline in NMDA receptor-mediated evoked-EPSCs is accompanied by increase in AMPA receptor-mediated evoked-EPSCs. Taken together, our findings document changes in inhibitory and excitatory synapses with regard to receptor utilization during the functional maturation of central vestibular neurons.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience.-
dc.relation.ispartofNeuroscience 2009-
dc.rightsNeuroscience 2009. Copyright © Society for Neuroscience.-
dc.subjectVestibular-
dc.subjectDevelopment-
dc.subjectSynaptic transmission-
dc.titleMaturation profile of inhibitory and excitatory postsynaptic currents in central vestibular neurons of ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, SK: laisk@hkucc.hku.hken_HK
dc.identifier.emailTse, YC: tseyc@hkusua.hku.hken_HK
dc.identifier.emailHu, H: h0694005@hku.hken_HK
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros174315en_HK
dc.publisher.placeUnited States-
dc.description.otherThe 39th Annual Meeting of the Society for Neuroscience (SfN), Chicago, IL., 17-21 October 2009.-

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