File Download

There are no files associated with this item.

Conference Paper: Chronic intermittent hypoxia induces oxidative stress and decreases NO production in the carotid artery of rats

TitleChronic intermittent hypoxia induces oxidative stress and decreases NO production in the carotid artery of rats
Authors
KeywordsCardiovascular disease
Issue Date2009
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 13th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 12 December 2009. In Journal of the Hong Kong College of Cardiology, 2009, v. 17 n. 2, p. 61, article no. P16 How to Cite?
AbstractObstructive sleep apnea (OSA) syndrome is a risk factor of hypertension and stroke. Chronic intermittent hypoxia (CIH) leads to oxidative stress and tissue injury. We examined the hypothesis that CIH-induced oxidative stress plays a pathophysiological role in the endothelial dysfunction in rat carotid artery. Adult Sprague-Dawley rats were exposed to IH treatment mimicking a severe OSA condition for 14 days. The carotid arteries were harvested for the malondialdehyde assay, PCR and Western-blotting analysis, and the measurement of nitric oxide (NO) with electrochemistry. Levels of malondialdehyde were significantly elevated in the hypoxic group when compared to the normoxic control. Also, the mRNA expressions of NADPH oxidase (gp91phox, p22phox) were markedly increased in the hypoxic group, indicating an involvement in the CIH-induced oxidative stress. In addition, the protein level of phosphorylated eNOS (ser1177) and the NO levels were notably lowered in the hypoxic group. These results suggest that oxidative stress induced by the CIH treatment deteriorates the endothelial function of the carotid artery with decreased NO bioavailability. These data may be clinically relevant to the increased risk for cerebrovascular disease in OSA patients.
Persistent Identifierhttp://hdl.handle.net/10722/126734

 

DC FieldValueLanguage
dc.contributor.authorLau, CFen_HK
dc.contributor.authorNg, KMen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorFung, MLen_HK
dc.date.accessioned2010-10-31T12:45:27Z-
dc.date.available2010-10-31T12:45:27Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 13th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 12 December 2009. In Journal of the Hong Kong College of Cardiology, 2009, v. 17 n. 2, p. 61, article no. P16en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126734-
dc.description.abstractObstructive sleep apnea (OSA) syndrome is a risk factor of hypertension and stroke. Chronic intermittent hypoxia (CIH) leads to oxidative stress and tissue injury. We examined the hypothesis that CIH-induced oxidative stress plays a pathophysiological role in the endothelial dysfunction in rat carotid artery. Adult Sprague-Dawley rats were exposed to IH treatment mimicking a severe OSA condition for 14 days. The carotid arteries were harvested for the malondialdehyde assay, PCR and Western-blotting analysis, and the measurement of nitric oxide (NO) with electrochemistry. Levels of malondialdehyde were significantly elevated in the hypoxic group when compared to the normoxic control. Also, the mRNA expressions of NADPH oxidase (gp91phox, p22phox) were markedly increased in the hypoxic group, indicating an involvement in the CIH-induced oxidative stress. In addition, the protein level of phosphorylated eNOS (ser1177) and the NO levels were notably lowered in the hypoxic group. These results suggest that oxidative stress induced by the CIH treatment deteriorates the endothelial function of the carotid artery with decreased NO bioavailability. These data may be clinically relevant to the increased risk for cerebrovascular disease in OSA patients.-
dc.languageengen_HK
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiologyen_HK
dc.rightsJournal of the Hong Kong College of Cardiology. © Hong Kong College of Cardiology.-
dc.subjectCardiovascular disease-
dc.titleChronic intermittent hypoxia induces oxidative stress and decreases NO production in the carotid artery of ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLau, CF: jeffery0820hk@yahoo.com.hken_HK
dc.identifier.emailNg, KM: h9925586@graduate.hku.hken_HK
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_HK
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_HK
dc.identifier.hkuros179019en_HK
dc.identifier.volume17en_HK
dc.identifier.issue2en_HK
dc.identifier.spage61, article no. P16-
dc.identifier.epage61, article no. P16-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats