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Conference Paper: A comprehensive identification of the microrna transcriptome and its application in B cell malignancies

TitleA comprehensive identification of the microrna transcriptome and its application in B cell malignancies
Authors
Issue Date2009
PublisherAmerican Society of Hematology. The Journal's web site is located at http://www.hematology.org/meetings
Citation
The 51st Annual Meeting and Exposition of the American Society of Hematology (ASH 2009), New Orleans, LA., 5-8 December 2009. In Blood, 2009, v. 114 n. 22, abstract 2403 How to Cite?
AbstractBACKGROUND: MicroRNAs are 18-22 nucleotide-long RNA molecules that regulate expression of genes. We and others have previously demonstrated a role for microRNAs in the pathogenesis of B cell malignancies. Computational predictions suggest that the human genome encodes several thousand microRNAs. Thus far, about 700 microRNAs have been discovered in humans, including over 200 new microRNAs in the past year alone. The ongoing discovery of microRNAs makes it difficult to comprehensively study their role in a disease group. The advent of high throughput sequencing allows the simultaneous identification of millions of transcripts, thereby providing a sensitivity that is several orders of magnitude higher than conventional methods. We hypothesized that high throughput sequencing would be an effective tool to comprehensively identify microRNAs in normal and malignant B cells …
DescriptionPoster Board 2-380: abstract 2403
Persistent Identifierhttp://hdl.handle.net/10722/126699
ISSN
2015 Impact Factor: 11.841
2015 SCImago Journal Rankings: 6.395

 

DC FieldValueLanguage
dc.contributor.authorJacobs, CLen_HK
dc.contributor.authorJima, DDen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorDunphy, Cen_HK
dc.contributor.authorRichards, KLen_HK
dc.contributor.authorChoi, WWLen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorEvens, AMen_HK
dc.contributor.authorGordon, LIen_HK
dc.contributor.authorCzader, Men_HK
dc.contributor.authorRizzieri, DAen_HK
dc.contributor.authorLagoo, ASen_HK
dc.contributor.authorMann, KPen_HK
dc.contributor.authorFlowers, CRen_HK
dc.contributor.authorNaresh, Ken_HK
dc.contributor.authorLuftig, Men_HK
dc.contributor.authorFriedman, DRen_HK
dc.contributor.authorWeinberg, JBen_HK
dc.contributor.authorThompson, MAen_HK
dc.contributor.authorGill, Jen_HK
dc.contributor.authorKahl, BSen_HK
dc.contributor.authorChadburn, Aen_HK
dc.contributor.authorDave, Sen_HK
dc.date.accessioned2010-10-31T12:43:25Z-
dc.date.available2010-10-31T12:43:25Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 51st Annual Meeting and Exposition of the American Society of Hematology (ASH 2009), New Orleans, LA., 5-8 December 2009. In Blood, 2009, v. 114 n. 22, abstract 2403en_HK
dc.identifier.issn0006-4971-
dc.identifier.urihttp://hdl.handle.net/10722/126699-
dc.descriptionPoster Board 2-380: abstract 2403-
dc.description.abstractBACKGROUND: MicroRNAs are 18-22 nucleotide-long RNA molecules that regulate expression of genes. We and others have previously demonstrated a role for microRNAs in the pathogenesis of B cell malignancies. Computational predictions suggest that the human genome encodes several thousand microRNAs. Thus far, about 700 microRNAs have been discovered in humans, including over 200 new microRNAs in the past year alone. The ongoing discovery of microRNAs makes it difficult to comprehensively study their role in a disease group. The advent of high throughput sequencing allows the simultaneous identification of millions of transcripts, thereby providing a sensitivity that is several orders of magnitude higher than conventional methods. We hypothesized that high throughput sequencing would be an effective tool to comprehensively identify microRNAs in normal and malignant B cells …-
dc.languageengen_HK
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://www.hematology.org/meetings-
dc.relation.ispartofBlood-
dc.rightsThis research was originally published in The Hematologist: ASH News and Reports. Jacobs, CL (et al). A comprehensive identification of the microrna transcriptome and its application in B cell malignancies. The Hematologist: ASH News and Reports. © the American Society of Hematology.-
dc.titleA comprehensive identification of the microrna transcriptome and its application in B cell malignanciesen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChoi, WWL: wlchoi@pathology.hku.hken_HK
dc.identifier.emailSrivastava, G: gopesh@pathology.hku.hken_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros170937en_HK
dc.identifier.volume114-
dc.identifier.issue22-
dc.publisher.placeUnited States-

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