File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: The effects of mal-placement of intervertebral disc allograft transplant on the kinematics of the spine

TitleThe effects of mal-placement of intervertebral disc allograft transplant on the kinematics of the spine
Authors
Issue Date2010
PublisherLippincott, Williams & Wilkins.
Citation
Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS 2010), Auckland, New Zealand, 13-17 April 2010. In Spine: Affiliate Society Meeting Abstracts, 2010 suppl. (October 2010), Special Poster Presentations: no. SP22 How to Cite?
AbstractINTRODUCTION: In a recent clinical trial of intervertebral disc (IVD) allograft transplantation by Ruan et al. (2007), remodelling of the transplanted allograft with reasonable preservation of segmental motion was observed. It is hypothesized that remodelling of a mal-positioned IVD allograft can restore the function and stability of the grafted functional spinal unit. METHODS: 18male goats (6-12 months, 25-30kg) were randomly assigned into 3groups: non-operated control group (n=6), centrally-placed allograft treatment group (n=6) and mal-positioned allograft treatment group (n=6). Transplantation of cryopreserved IVD allografts was performed in the lumbar region (L4-L5). In the centrally-placed treatment group, the IVD allografts were placed centred and flush with the vertebral margin. In the mal-positioned group, the allografts were placed anteriorly by 25% of the anterior-posterior length of the allograft. Lateral and flexion/extension radiographs were taken at 4, 12 and 24weeks post-operatively. Measurement of disc height index (% DHI), range of motion (ROM) and centre of rotation (COR) were made using an image analysis program developed in MATLAB. The results were compared to the nonoperated control group using student t-test with P<0.05 being considered as significant. RESULTS: The % DHI of both groups showed an initial decrease at 4 wks (80%) but stabilised at 12 wks (79%) and 24 wks (80%). No significant differences in the ROM was observed, both the centrally placed and the mal-positioned allograft were able to preserve segmental motion. No significant differences were found in the COR among the groups at different time points with the quality of the motion also preserved. CONCLUSION: Mal-positioned allograft transplantation was compatible with good functional outcome. In contrast to artificial disc replacements, precise positioning of allograft during transplantation is not essential for functional success.
Persistent Identifierhttp://hdl.handle.net/10722/126613
ISSN
2015 Impact Factor: 2.439
2015 SCImago Journal Rankings: 1.459

 

DC FieldValueLanguage
dc.contributor.authorLam, SKLen_HK
dc.contributor.authorXiao, Jen_HK
dc.contributor.authorRuan, Den_HK
dc.contributor.authorDing, Yen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-10-31T12:38:32Z-
dc.date.available2010-10-31T12:38:32Z-
dc.date.issued2010en_HK
dc.identifier.citationAnnual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS 2010), Auckland, New Zealand, 13-17 April 2010. In Spine: Affiliate Society Meeting Abstracts, 2010 suppl. (October 2010), Special Poster Presentations: no. SP22en_HK
dc.identifier.issn0362-2436-
dc.identifier.urihttp://hdl.handle.net/10722/126613-
dc.description.abstractINTRODUCTION: In a recent clinical trial of intervertebral disc (IVD) allograft transplantation by Ruan et al. (2007), remodelling of the transplanted allograft with reasonable preservation of segmental motion was observed. It is hypothesized that remodelling of a mal-positioned IVD allograft can restore the function and stability of the grafted functional spinal unit. METHODS: 18male goats (6-12 months, 25-30kg) were randomly assigned into 3groups: non-operated control group (n=6), centrally-placed allograft treatment group (n=6) and mal-positioned allograft treatment group (n=6). Transplantation of cryopreserved IVD allografts was performed in the lumbar region (L4-L5). In the centrally-placed treatment group, the IVD allografts were placed centred and flush with the vertebral margin. In the mal-positioned group, the allografts were placed anteriorly by 25% of the anterior-posterior length of the allograft. Lateral and flexion/extension radiographs were taken at 4, 12 and 24weeks post-operatively. Measurement of disc height index (% DHI), range of motion (ROM) and centre of rotation (COR) were made using an image analysis program developed in MATLAB. The results were compared to the nonoperated control group using student t-test with P<0.05 being considered as significant. RESULTS: The % DHI of both groups showed an initial decrease at 4 wks (80%) but stabilised at 12 wks (79%) and 24 wks (80%). No significant differences in the ROM was observed, both the centrally placed and the mal-positioned allograft were able to preserve segmental motion. No significant differences were found in the COR among the groups at different time points with the quality of the motion also preserved. CONCLUSION: Mal-positioned allograft transplantation was compatible with good functional outcome. In contrast to artificial disc replacements, precise positioning of allograft during transplantation is not essential for functional success.-
dc.languageengen_HK
dc.publisherLippincott, Williams & Wilkins.-
dc.relation.ispartofAnnual Meeting of the International Society for the Study of the Lumbar Spine-
dc.titleThe effects of mal-placement of intervertebral disc allograft transplant on the kinematics of the spineen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0362-2436&volume=2010&spage=&epage=&date=2010&atitle=The+effects+of+mal-placement+of+intervertebral+disc+allograft+transplant+on+the+kinematics+of+the+spine-
dc.identifier.emailLam, SKL: skllam@gmail.comen_HK
dc.identifier.emailXiao, J: orthopaedxj@163.comen_HK
dc.identifier.emailLu, WW: wwlu@hkusua.hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros180322en_HK
dc.identifier.volumeOctober 2010-
dc.identifier.issuesuppl.-
dc.description.otherAnnual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS 2010), Auckland, New Zealand, 13-17 April 2010. In Spine: Affiliate Society Meeting Abstracts, 2010 suppl. (October 2010), Special Poster Presentations: no. SP22-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats