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Conference Paper: In vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells

TitleIn vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cells
Authors
KeywordsAdipogenesis
Bone marrow stromal cells
Osteoblastogenesis
Osteoporosis
Strontium
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthres
Citation
The 56th Annual Meeting of the Orthopaedic Research Society (ORS 2010), New Orleans, LA., 6-9 March 2010. In Journal of Orthopaedic Research , 2010, v. 28 n. 9, p. 1208-1214 How to Cite?
AbstractIn vitro studies have demonstrated that strontium (Sr) could increase osteogenic differentiation of bone marrow stromal cells (BMSCs). We investigated the in vivo effect of Sr on BMSCs. Thirty-six female rats were randomly divided into the following groups: sham operated and treated with either vehicle (Sham + Veh) or Sr compound (Sham + Sr) and ovariectomized and treated with either vehicle (OVX + Veh) or Sr compound(OVX + Sr). Vehicle and Sr were orally administrated daily starting immediately after the surgery and continuing for 12 weeks. The anabolic effect of Sr on trabecular bone was determined at the structural and tissue level by microCT and histomorphometry, respectively. Colony formation assays demonstrated that BMSCs exhibited higher osteogenic colony but lower adipogenic colony in Sr-treated versus Veh-treated OVX rats. Them RNA level of osteogenic genes was higher, while them RNA level of adipogenic genes was lower in BMSCs from Sr-treated versus Veh-treated Sham and OVX rats. The effect of Sr on rat BMSCs was reproducible in human BMSCs. Taken together, this study suggests that the anabolic effect of Sr on normal or osteoporotic bones is associated with increased osteoblastic differentiation of BMSCs. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/126604
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.464
ISI Accession Number ID
Funding AgencyGrant Number
Innovation and Technology Fund (ITF)GHP/009/06
Funding Information:

This study was supported by Innovation and Technology Fund (ITF) (Project Ref. No. GHP/009/06).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorPeng, Sen_HK
dc.contributor.authorLiu, XSen_HK
dc.contributor.authorWang, Ten_HK
dc.contributor.authorLi, Zen_HK
dc.contributor.authorZhou, Gen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorGuo, XEen_HK
dc.contributor.authorLu, WWen_HK
dc.date.accessioned2010-10-31T12:38:02Z-
dc.date.available2010-10-31T12:38:02Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 56th Annual Meeting of the Orthopaedic Research Society (ORS 2010), New Orleans, LA., 6-9 March 2010. In Journal of Orthopaedic Research , 2010, v. 28 n. 9, p. 1208-1214en_HK
dc.identifier.issn0736-0266en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126604-
dc.description.abstractIn vitro studies have demonstrated that strontium (Sr) could increase osteogenic differentiation of bone marrow stromal cells (BMSCs). We investigated the in vivo effect of Sr on BMSCs. Thirty-six female rats were randomly divided into the following groups: sham operated and treated with either vehicle (Sham + Veh) or Sr compound (Sham + Sr) and ovariectomized and treated with either vehicle (OVX + Veh) or Sr compound(OVX + Sr). Vehicle and Sr were orally administrated daily starting immediately after the surgery and continuing for 12 weeks. The anabolic effect of Sr on trabecular bone was determined at the structural and tissue level by microCT and histomorphometry, respectively. Colony formation assays demonstrated that BMSCs exhibited higher osteogenic colony but lower adipogenic colony in Sr-treated versus Veh-treated OVX rats. Them RNA level of osteogenic genes was higher, while them RNA level of adipogenic genes was lower in BMSCs from Sr-treated versus Veh-treated Sham and OVX rats. The effect of Sr on rat BMSCs was reproducible in human BMSCs. Taken together, this study suggests that the anabolic effect of Sr on normal or osteoporotic bones is associated with increased osteoblastic differentiation of BMSCs. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.elsevier.com/locate/orthresen_HK
dc.relation.ispartofJournal of Orthopaedic Researchen_HK
dc.rightsJournal of Orthopaedic Research . Copyright © John Wiley & Sons, Inc.-
dc.subjectAdipogenesisen_HK
dc.subjectBone marrow stromal cellsen_HK
dc.subjectOsteoblastogenesisen_HK
dc.subjectOsteoporosisen_HK
dc.subjectStrontiumen_HK
dc.subject.meshAnabolic Agents - pharmacology-
dc.subject.meshBone Marrow Cells - cytology - drug effects-
dc.subject.meshOsteoblasts - cytology - drug effects-
dc.subject.meshOsteoporosis - drug therapy - pathology-
dc.subject.meshStrontium - pharmacology-
dc.titleIn vivo anabolic effect of strontium on trabecular bone was associated with increased osteoblastogenesis of bone marrow stromal cellsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0736-0266&volume=28&issue=9&spage=1208&epage=1214&date=2010&atitle=In+vivo+anabolic+effect+of+strontium+on+trabecular+bone+was+associated+with+increased+osteoblastogenesis+of+bone+marrow+stromal+cells-
dc.identifier.emailZhou, G:wormoscz@gmail.comen_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.authorityZhou, G=rp00527en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jor.21127en_HK
dc.identifier.pmid20196084-
dc.identifier.scopuseid_2-s2.0-77955914535en_HK
dc.identifier.hkuros180297en_HK
dc.identifier.hkuros196984-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955914535&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1208en_HK
dc.identifier.epage1214en_HK
dc.identifier.isiWOS:000280897100014-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectOptimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications-
dc.identifier.scopusauthoridPeng, S=13402746900en_HK
dc.identifier.scopusauthoridLiu, XS=36463860300en_HK
dc.identifier.scopusauthoridWang, T=7405564863en_HK
dc.identifier.scopusauthoridLi, Z=35784563200en_HK
dc.identifier.scopusauthoridZhou, G=23394245100en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridGuo, XE=35237105200en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.customcontrol.immutablesml 160516 amend-

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