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Conference Paper: The kinematics of the mal-placement of the intervertebral disc allograft transplant on the segmental mobility

TitleThe kinematics of the mal-placement of the intervertebral disc allograft transplant on the segmental mobility
Authors
Issue Date2009
Citation
The 6th SICOT/SIROT Annual International Conference, combined meeting with the Royal College of Orthopaedic Surgeons of Thailand (RCOST), Pattaya, Thailand, 29 October-1 November 2009. How to Cite?
Abstract
In a recent clinical trial of the Intervertebral disc (IVD) allograft transplantation, Ruan et al. (2007) observed remodelling of the transplanted allograft with reasonable preservation of segmental motion. We hypothesized that remodelling of a mal-positioned allograft implant can restore the function and stability of the grafted functional spinal unit (FSU). 18 male goats (age 6-12 months, weight 25-30 kg) were used in this study. The goats were randomly assigned into a control group (n=5), a centrally placed allograft group (n=5) and a mal-positioned allograft group (in=5). IVD were obtained from sacrificed goats (n=3) and were cryopreserved in liquid nitrogen. Transplantation of a size matching fresh-frozen IVD allograft was performed in the lumbar region (L4-L5) after disc excision. In the centrally placed allograft group, the IVD allografts were placed centered and flush with the vertebral margin. In the al-positioned allograft group, the allografts were placed anteriorly by 25% of the anterior-posterior length of the allograft. Post-operational lateral, flexion-extension x-rays were taken at 4 and 12 weeks for analysis. No significant differences in the range of motion were found among the groups at different time points. The disc height of the grafted segment showed an initial decrease at 4 wks (80%) but this decrease was stabilised at 12 wks (79%). Both the centrally placed and the mal-positioned allograft were able to preserve segmental motion. Mal-positioned allograft transplantation is compatible with good functional outcome through remodelling. In contrast to artificial disc replacement, precise positioning of allograft is not essential for functional success.
DescriptionPoster Presentations: Session: Degenerative diseases / Varia - Spine. Abstract no. 21695 - http://www.sicot.org/resources/File/Pattaya/abstract%20cdrom_posters.pdf
Persistent Identifierhttp://hdl.handle.net/10722/126563

 

DC FieldValueLanguage
dc.contributor.authorLam, SKLen_HK
dc.contributor.authorXiao, Jen_HK
dc.contributor.authorRuan, Den_HK
dc.contributor.authorDing, Yen_HK
dc.contributor.authorLu, Wen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-10-31T12:35:46Z-
dc.date.available2010-10-31T12:35:46Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 6th SICOT/SIROT Annual International Conference, combined meeting with the Royal College of Orthopaedic Surgeons of Thailand (RCOST), Pattaya, Thailand, 29 October-1 November 2009.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126563-
dc.descriptionPoster Presentations: Session: Degenerative diseases / Varia - Spine. Abstract no. 21695 - http://www.sicot.org/resources/File/Pattaya/abstract%20cdrom_posters.pdf-
dc.description.abstractIn a recent clinical trial of the Intervertebral disc (IVD) allograft transplantation, Ruan et al. (2007) observed remodelling of the transplanted allograft with reasonable preservation of segmental motion. We hypothesized that remodelling of a mal-positioned allograft implant can restore the function and stability of the grafted functional spinal unit (FSU). 18 male goats (age 6-12 months, weight 25-30 kg) were used in this study. The goats were randomly assigned into a control group (n=5), a centrally placed allograft group (n=5) and a mal-positioned allograft group (in=5). IVD were obtained from sacrificed goats (n=3) and were cryopreserved in liquid nitrogen. Transplantation of a size matching fresh-frozen IVD allograft was performed in the lumbar region (L4-L5) after disc excision. In the centrally placed allograft group, the IVD allografts were placed centered and flush with the vertebral margin. In the al-positioned allograft group, the allografts were placed anteriorly by 25% of the anterior-posterior length of the allograft. Post-operational lateral, flexion-extension x-rays were taken at 4 and 12 weeks for analysis. No significant differences in the range of motion were found among the groups at different time points. The disc height of the grafted segment showed an initial decrease at 4 wks (80%) but this decrease was stabilised at 12 wks (79%). Both the centrally placed and the mal-positioned allograft were able to preserve segmental motion. Mal-positioned allograft transplantation is compatible with good functional outcome through remodelling. In contrast to artificial disc replacement, precise positioning of allograft is not essential for functional success.-
dc.languageengen_HK
dc.relation.ispartofCombined SICOT/RCOST Annual Meeting-
dc.titleThe kinematics of the mal-placement of the intervertebral disc allograft transplant on the segmental mobilityen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLam, SKL: skllam@gmail.comen_HK
dc.identifier.emailLu, W: wwlu@hkusua.hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_HK
dc.identifier.authorityLu, W=rp00411en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.hkuros180235en_HK
dc.description.otherThe 6th SICOT/SIROT Annual International Conference, combined meeting with the Royal College of Orthopaedic Surgeons of Thailand (RCOST), Pattaya, Thailand, 29 October-1 November 2009.-

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