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Conference Paper: Precise diagnosis of cervical spondylotic myelopathy based on quantitative fiber tractography

TitlePrecise diagnosis of cervical spondylotic myelopathy based on quantitative fiber tractography
Authors
KeywordsMedical sciences
Surgery medical sciences
Psychiatry and neurology
Issue Date2010
PublisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586
Citation
The 26th Annual Meeting of the European Section of the Cervical Spine Research Society (CSRS-ES 2010), Corfu Island, Greece, 26-29 May 2010. In European Spine Journal, 2010, v. 19 n. 6, p. 1054 How to Cite?
AbstractINTRODUCTION: The insidious onset and variety of clinical symptoms and signs of cervical spondylotic myelopathy (CSM) pose a big challenges to clinician for early diagnosis and precise prognostication. The gross morphological and signal changes in T2-weighted magnetic resonance images (MRI) did not necessarily correlate with the severity of chronic compressive injuries of cervical spinal cord. In the present study, we aimed to employ a relatively novel diffusion MRI imaging and fiber tractography techniques to quantify the damages of nerve fibers in spinal cord in CSM patients. METHODS: Total 14 volunteers were recruited in this study with informed consent, including 5 adult healthy subjects (group A, 25 ± 2 years), 5 elderly healthy subjects (group B, 53 ± 3 years) and 4 CSM patients (group C, 53 ± 8 years). Diffusion MR Imaging MR imaging of cervical spinal cord were performed with a 3T Philips MR system (Philips Medical System, Netherlands). T1 and T2-weighted images were obtained and diffusion MRI images were also taken using pulsed gradient, spin-echo-echo-planar imaging (SE-EPI) sequence(data acquisition parameters: TR/TS = 5000/60 ms; 13 slices (7 mm slice thickness, 2.2 mm gap); field of view (FOV) = 80 (RL) 9 36 (AP) mm; matrix size = 128 9 128; non-collinear diffusion encoding directions = 16, b = 600 s/mm2; reconstruction resolution = 0.63 9 0.64 9 7.0 mm3; acquisition time = 8 min). Fiber trachtography was done via TrackVis. The density of nerve fibers (unit/mm2) ventral, lateral and dorsal column of white matter in the cord, was calculated, respectively. RESULTS: It was revealed in T2-weighted image of four CSM patients that the spinal cords were compressed by degenerated disc from ventrally. Yet it was found that the nerve fiber density was significantly lower in dorsal column of spinal cord in these four patients as compared with adult and elderly healthy subjects (group A: 0.432 ± 0.033; B: 0.418 ± 0.023; C: 0.276 ± 0.028; p﹤0.05). There were no significant differences in either ventral (group A: 0.315 ± 0.037; B: 0.368 ± 0.026; C: 0.359 ± 0.020) or lateral columns among groups (group A: 0.368 ± 0.032; B: 0.380 ± 0.031; C: 0.364 ± 0.012). CONCLUSION: The discontinuity of nerve fibers were present in dorsal column of spinal cord with ventral compression in CSM patients. It suggested the underlying mechanism of CSM might not result from the effect of direct compression.
DescriptionSession 3 - Free Communication papers
Persistent Identifierhttp://hdl.handle.net/10722/126561
ISSN
2015 Impact Factor: 2.132
2015 SCImago Journal Rankings: 0.972

 

DC FieldValueLanguage
dc.contributor.authorCui, Jen_HK
dc.contributor.authorWen, Cen_HK
dc.contributor.authorHu, Yen_HK
dc.contributor.authorLuk, KDK-
dc.date.accessioned2010-10-31T12:35:40Z-
dc.date.available2010-10-31T12:35:40Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 26th Annual Meeting of the European Section of the Cervical Spine Research Society (CSRS-ES 2010), Corfu Island, Greece, 26-29 May 2010. In European Spine Journal, 2010, v. 19 n. 6, p. 1054en_HK
dc.identifier.issn0940-6719-
dc.identifier.urihttp://hdl.handle.net/10722/126561-
dc.descriptionSession 3 - Free Communication papers-
dc.description.abstractINTRODUCTION: The insidious onset and variety of clinical symptoms and signs of cervical spondylotic myelopathy (CSM) pose a big challenges to clinician for early diagnosis and precise prognostication. The gross morphological and signal changes in T2-weighted magnetic resonance images (MRI) did not necessarily correlate with the severity of chronic compressive injuries of cervical spinal cord. In the present study, we aimed to employ a relatively novel diffusion MRI imaging and fiber tractography techniques to quantify the damages of nerve fibers in spinal cord in CSM patients. METHODS: Total 14 volunteers were recruited in this study with informed consent, including 5 adult healthy subjects (group A, 25 ± 2 years), 5 elderly healthy subjects (group B, 53 ± 3 years) and 4 CSM patients (group C, 53 ± 8 years). Diffusion MR Imaging MR imaging of cervical spinal cord were performed with a 3T Philips MR system (Philips Medical System, Netherlands). T1 and T2-weighted images were obtained and diffusion MRI images were also taken using pulsed gradient, spin-echo-echo-planar imaging (SE-EPI) sequence(data acquisition parameters: TR/TS = 5000/60 ms; 13 slices (7 mm slice thickness, 2.2 mm gap); field of view (FOV) = 80 (RL) 9 36 (AP) mm; matrix size = 128 9 128; non-collinear diffusion encoding directions = 16, b = 600 s/mm2; reconstruction resolution = 0.63 9 0.64 9 7.0 mm3; acquisition time = 8 min). Fiber trachtography was done via TrackVis. The density of nerve fibers (unit/mm2) ventral, lateral and dorsal column of white matter in the cord, was calculated, respectively. RESULTS: It was revealed in T2-weighted image of four CSM patients that the spinal cords were compressed by degenerated disc from ventrally. Yet it was found that the nerve fiber density was significantly lower in dorsal column of spinal cord in these four patients as compared with adult and elderly healthy subjects (group A: 0.432 ± 0.033; B: 0.418 ± 0.023; C: 0.276 ± 0.028; p﹤0.05). There were no significant differences in either ventral (group A: 0.315 ± 0.037; B: 0.368 ± 0.026; C: 0.359 ± 0.020) or lateral columns among groups (group A: 0.368 ± 0.032; B: 0.380 ± 0.031; C: 0.364 ± 0.012). CONCLUSION: The discontinuity of nerve fibers were present in dorsal column of spinal cord with ventral compression in CSM patients. It suggested the underlying mechanism of CSM might not result from the effect of direct compression.-
dc.languageengen_HK
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/586-
dc.relation.ispartofEuropean Spine Journal-
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectMedical sciences-
dc.subjectSurgery medical sciences-
dc.subjectPsychiatry and neurology-
dc.titlePrecise diagnosis of cervical spondylotic myelopathy based on quantitative fiber tractographyen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWen, C: paulwen@hku.hken_HK
dc.identifier.emailHu, Y: yhud@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hk-
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.doi10.1007/s00586-010-1436-4-
dc.identifier.hkuros174687en_HK
dc.identifier.hkuros188853-
dc.identifier.volume19-
dc.identifier.issue6-
dc.identifier.spage1054-
dc.identifier.epage1054-
dc.publisher.placeGermany-
dc.description.otherThe 26th Annual Meeting of the European Section of the Cervical Spine Research Society (CSRS-ES 2010), Corfu Island, Greece, 26-29 May 2010. In European Spine Journal, 2010, v. 19 n. 6, p. 1054-

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