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Conference Paper: Post-operative monitoring of nickel ion level in scoliotic patients operated with novel nickel-titanium superelastic spinal implant

TitlePost-operative monitoring of nickel ion level in scoliotic patients operated with novel nickel-titanium superelastic spinal implant
Authors
Issue Date2010
PublisherSpringer
Citation
International Conference on Shape Memory and Superelastic Technologies (SMST), Pacific Grove, CA., 16-20 May 2010. In SMST-2010: Global Solutions for Future Applications, 2011, p. 22-23 How to Cite?
AbstractNickel-titanium (NiTi) shape memory alloys have been used as surgical implants in orthopaedic procedures. However, nickel ion release remains a concern. Therefore, an advanced surface technology using plasma immersion ion implantation (PIII) has been developed to address this issue. This paper describes serum nickel ion level monitoring of patients with scoliosis operated upon using nitrogen plasma implanted NiTi spinal rods compared with standard titanium alloy rods in a randomized human clinical trial. NiTi spinal rods with 50.8% Ni were treated by nitrogen PIII at 40kV with 100Hz. Seventeen patients with spinal scoliosis were surgically treated by either Ti alloy rods or nitrogen plasma implanted NiTi rods. The mean age at operation was 16.6 years. The mean number of treated spinal segments was 9. Blood samples were collected as baseline before surgery and up to 1 year post-surgery. Nickel levels were assayed by inductively coupled plasma mass spectrometry. Twelve patients (7M and 5F, 6=NiTi and 6=Ti) were followed up for 6 months, and five patients (2M and 3F, 2=NiTi and 3=Ti) had completed 1-year follow-up. In all cases, at Day 1 after surgery, patients who had NiTi rods implanted had a 2.5 times increase in the Ni level, compared with before surgery. However, all were within recommended safe limits. The Ni levels returned to baseline in all subjects between 7 days to 1 month post-surgery. No clinical signs and symptoms of Ni allergy or toxicity was observed. SUMMARY: Nickel-titanium (NiTi) shape memory alloys have been used as surgical implants in orthopaedic procedures. However, nickel ion release remains a concern. Therefore, an advanced surface technology using plasma immersion ion implantation (PIII) has been developed to address this issue. This paper describes serum nickel ion level monitoring of patients with scoliosis operated upon using nitrogen plasma implanted NiTi spinal rods compared with standard titanium alloy rods in a randomized human clinical trial.
Persistent Identifierhttp://hdl.handle.net/10722/126495
ISBN

 

DC FieldValueLanguage
dc.contributor.authorYeung, KWKen_HK
dc.contributor.authorLam, Wen_HK
dc.contributor.authorNatarajan, Den_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorWu, SLen_HK
dc.contributor.authorT, Huen_HK
dc.contributor.authorChu, PKen_HK
dc.contributor.authorChung, CY-
dc.date.accessioned2010-10-31T12:32:02Z-
dc.date.available2010-10-31T12:32:02Z-
dc.date.issued2010en_HK
dc.identifier.citationInternational Conference on Shape Memory and Superelastic Technologies (SMST), Pacific Grove, CA., 16-20 May 2010. In SMST-2010: Global Solutions for Future Applications, 2011, p. 22-23en_HK
dc.identifier.isbn978-1-4614-0197-1-
dc.identifier.urihttp://hdl.handle.net/10722/126495-
dc.description.abstractNickel-titanium (NiTi) shape memory alloys have been used as surgical implants in orthopaedic procedures. However, nickel ion release remains a concern. Therefore, an advanced surface technology using plasma immersion ion implantation (PIII) has been developed to address this issue. This paper describes serum nickel ion level monitoring of patients with scoliosis operated upon using nitrogen plasma implanted NiTi spinal rods compared with standard titanium alloy rods in a randomized human clinical trial. NiTi spinal rods with 50.8% Ni were treated by nitrogen PIII at 40kV with 100Hz. Seventeen patients with spinal scoliosis were surgically treated by either Ti alloy rods or nitrogen plasma implanted NiTi rods. The mean age at operation was 16.6 years. The mean number of treated spinal segments was 9. Blood samples were collected as baseline before surgery and up to 1 year post-surgery. Nickel levels were assayed by inductively coupled plasma mass spectrometry. Twelve patients (7M and 5F, 6=NiTi and 6=Ti) were followed up for 6 months, and five patients (2M and 3F, 2=NiTi and 3=Ti) had completed 1-year follow-up. In all cases, at Day 1 after surgery, patients who had NiTi rods implanted had a 2.5 times increase in the Ni level, compared with before surgery. However, all were within recommended safe limits. The Ni levels returned to baseline in all subjects between 7 days to 1 month post-surgery. No clinical signs and symptoms of Ni allergy or toxicity was observed. SUMMARY: Nickel-titanium (NiTi) shape memory alloys have been used as surgical implants in orthopaedic procedures. However, nickel ion release remains a concern. Therefore, an advanced surface technology using plasma immersion ion implantation (PIII) has been developed to address this issue. This paper describes serum nickel ion level monitoring of patients with scoliosis operated upon using nitrogen plasma implanted NiTi spinal rods compared with standard titanium alloy rods in a randomized human clinical trial.-
dc.languageengen_HK
dc.publisherSpringer-
dc.relation.ispartofSMST-2010: Global Solutions for Future Applications - Proceedings of the International Conference on Shape Memory and Superelastic Technology-
dc.titlePost-operative monitoring of nickel ion level in scoliotic patients operated with novel nickel-titanium superelastic spinal implanten_HK
dc.typeConference_Paperen_HK
dc.identifier.emailYeung, KWK: wkkyeung@hkucc.hku.hken_HK
dc.identifier.emailLam, W: jwnlam@hku.hken_HK
dc.identifier.emailNatarajan, D: hkdeepa@gmail.comen_HK
dc.identifier.emailLu, WW: wwlu@hkusua.hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.hkuros172965en_HK
dc.identifier.spage22en_HK
dc.identifier.epage23en_HK
dc.description.otherInternational Conference on Shape Memory and Superelastic Technologies (SMST), Pacific Grove, CA., 16-20 May 2010. In SMST-2010: Global Solutions for Future Applications, 2011, p. 22-23-

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