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Conference Paper: Association of candidate susceptible loci with chronic hepatitisB virus infection in a Chinese population

TitleAssociation of candidate susceptible loci with chronic hepatitisB virus infection in a Chinese population
Authors
Issue Date2010
PublisherBlackwell Publishing.
Citation
The 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 20), Vienna, Austria, 10-13 April 2010. How to Cite?
AbstractOBJECTIVES: A number of genetic loci have been proposed to be associated with persistent hepatitis B virus (HBV) infection. In this study, we aimed to evaluate the association and interaction of susceptible genes with HBV persistence in Chinese population. METHODS: Seventeen polymorphisms in 9 candidate genes were studied in 361 Chinese chronic hepatitis B patients (CHP group) and 304 spontaneously recovered individuals (SRI). Distribution frequencies of polymorphisms associated with disease were analyzed in healthy Chinese and Caucasian populations. Gene-gene interactions were tested by the multifactor dimensionality reduction (MDR) method. RESULTS: The TNF -308 G/G genotype and G allele, IL-10RB codon 47 A allele, and MCP-1 -2518 G/G genotype and G allele were more frequent in patients than controls (P < 0.01, after multiple corrections Pc < 0.05), while TNF -308 A/G genotype and IL-10 -592 A/A genotype were significantly higher in the SRI group than in the CHP group (Pc < 0.05). The distribution frequency of risk allele MCP-1 -2518 G and CTLA4 6230 G were much higher in Chinese than Caucasian groups (P < 0.001). An interaction between CCR5 -2459, TNFA -863, IL-10RB codon 47 and MCP-1 -2518 was detected by MDR (P = 0.001). CONCLUSION: Our results suggest that genetic determinants may affect the outcome of HBV infection in both independent and synergic manners.
DescriptionAbstract no. P1140
Persistent Identifierhttp://hdl.handle.net/10722/126468

 

DC FieldValueLanguage
dc.contributor.authorChen, Den_HK
dc.contributor.authorZheng, Ben_HK
dc.date.accessioned2010-10-31T12:30:24Z-
dc.date.available2010-10-31T12:30:24Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 20), Vienna, Austria, 10-13 April 2010.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126468-
dc.descriptionAbstract no. P1140-
dc.description.abstractOBJECTIVES: A number of genetic loci have been proposed to be associated with persistent hepatitis B virus (HBV) infection. In this study, we aimed to evaluate the association and interaction of susceptible genes with HBV persistence in Chinese population. METHODS: Seventeen polymorphisms in 9 candidate genes were studied in 361 Chinese chronic hepatitis B patients (CHP group) and 304 spontaneously recovered individuals (SRI). Distribution frequencies of polymorphisms associated with disease were analyzed in healthy Chinese and Caucasian populations. Gene-gene interactions were tested by the multifactor dimensionality reduction (MDR) method. RESULTS: The TNF -308 G/G genotype and G allele, IL-10RB codon 47 A allele, and MCP-1 -2518 G/G genotype and G allele were more frequent in patients than controls (P < 0.01, after multiple corrections Pc < 0.05), while TNF -308 A/G genotype and IL-10 -592 A/A genotype were significantly higher in the SRI group than in the CHP group (Pc < 0.05). The distribution frequency of risk allele MCP-1 -2518 G and CTLA4 6230 G were much higher in Chinese than Caucasian groups (P < 0.001). An interaction between CCR5 -2459, TNFA -863, IL-10RB codon 47 and MCP-1 -2518 was detected by MDR (P = 0.001). CONCLUSION: Our results suggest that genetic determinants may affect the outcome of HBV infection in both independent and synergic manners.-
dc.languageengen_HK
dc.publisherBlackwell Publishing.-
dc.relation.ispartofEuropean Congress of Clinical Microbiology and Infectious Diseases-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleAssociation of candidate susceptible loci with chronic hepatitisB virus infection in a Chinese populationen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChen, D: chendq@hku.hken_HK
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hk-
dc.identifier.authorityZheng, B=rp00353en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros175113en_HK
dc.description.otherThe 20th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 20), Vienna, Austria, 10-13 April 2010.-

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