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Conference Paper: Comparison of factors associated with total sRAGE and esRAGE in patients with type 2 diabetes

TitleComparison of factors associated with total sRAGE and esRAGE in patients with type 2 diabetes
Authors
KeywordsMedical sciences
Endocrinology
Issue Date2010
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
The 70th Scientific Sessions of the American Diabetes Association (ADA), Orlando, FL., 25-29 June 2010. In Diabetes, 2010, v. 59 suppl., abstract no. 1108-P How to Cite?
AbstractCirculating soluble receptor for advanced glycation endproducts (total sRAGE) likely comprises both a secreted isoform lacking a transmembrane domain (esRAGE) and cleavage of RAGE from the cell surface. Which of these sources of sRAGE is more relevant to vascular disease prediction is unclear. We examined whether the determinants of esRAGE and total sRAGE levels differ and whether they have different relationships with coronary heart disease in the type 2 Diabetes patients in Collaborative Atorvastatin Diabetes Study (CARDS). We used a nested case control design sampling incident cases of CVD with available plasma (n=198) in the CARDS trial and randomly selecting three controls per case stratified by treatment. The median follow up was 3.9 years. Serum sRAGE was measured using the R&D Systems Quantikine Immunoassay (specific for the extracellular domain of human RAGE). The assay coefficient of variation was 4.4%. esRAGE was measured using the B-Bridge ELISA CV 6%. Analysis was by Cox regression with adjustment for treatment allocation and relevant covariates. Total and esRAGE were strongly correlated (Spearman's rho =0.88) with a median ratio of total to esRAGE levels of 4.2 (interquartile range 3.7 to 4.8). Higher esRAGE was associated with lower BMI (p<0.001), lower eGFR (p=0.009), higher adiponectin (p<0.001) and white ethnicity (p<0.001). These relationships were similar to those for total sRAGE but these factors explained no more than 10% of the variance in either. esRAGE was an independent predictor of coronary heart disease events (HR=1.5 for a doubling of the esRAGE level, 95% CI: 1.1,2.0 p=0.009 adjusted for age, sex, eGFR, ethnicity, BMI, lipids and treatment allocation). This relationship was slightly weaker than the association of total sRAGE with CHD (p=0.001, difference in log likelihood=-2) and was not independent of total-esRAGE. In conclusion esRAGE is not more informative of vascular risk than total sRAGE and shares similar associations with other risk factors.
DescriptionThis journal supplement with title: Abstract Book 70th Scientific Sessions
Category: Epidemiology - abstract no. 1108-P
Persistent Identifierhttp://hdl.handle.net/10722/126450
ISSN
2015 Impact Factor: 8.784
2015 SCImago Journal Rankings: 5.185

 

DC FieldValueLanguage
dc.contributor.authorColhoun, HMen_HK
dc.contributor.authorDurrington, PNen_HK
dc.contributor.authorFuller, JHen_HK
dc.contributor.authorHitman, GAen_HK
dc.contributor.authorNeil, AWen_HK
dc.contributor.authorLivingstone, SJen_HK
dc.contributor.authorCharlton-Menys, Ven_HK
dc.contributor.authorBao, WHen_HK
dc.contributor.authorDeMicco, DAen_HK
dc.contributor.authorPreston, GMen_HK
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorBetteridge, DJen_HK
dc.date.accessioned2010-10-31T12:29:17Z-
dc.date.available2010-10-31T12:29:17Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 70th Scientific Sessions of the American Diabetes Association (ADA), Orlando, FL., 25-29 June 2010. In Diabetes, 2010, v. 59 suppl., abstract no. 1108-Pen_HK
dc.identifier.issn0012-1797-
dc.identifier.urihttp://hdl.handle.net/10722/126450-
dc.descriptionThis journal supplement with title: Abstract Book 70th Scientific Sessions-
dc.descriptionCategory: Epidemiology - abstract no. 1108-P-
dc.description.abstractCirculating soluble receptor for advanced glycation endproducts (total sRAGE) likely comprises both a secreted isoform lacking a transmembrane domain (esRAGE) and cleavage of RAGE from the cell surface. Which of these sources of sRAGE is more relevant to vascular disease prediction is unclear. We examined whether the determinants of esRAGE and total sRAGE levels differ and whether they have different relationships with coronary heart disease in the type 2 Diabetes patients in Collaborative Atorvastatin Diabetes Study (CARDS). We used a nested case control design sampling incident cases of CVD with available plasma (n=198) in the CARDS trial and randomly selecting three controls per case stratified by treatment. The median follow up was 3.9 years. Serum sRAGE was measured using the R&D Systems Quantikine Immunoassay (specific for the extracellular domain of human RAGE). The assay coefficient of variation was 4.4%. esRAGE was measured using the B-Bridge ELISA CV 6%. Analysis was by Cox regression with adjustment for treatment allocation and relevant covariates. Total and esRAGE were strongly correlated (Spearman's rho =0.88) with a median ratio of total to esRAGE levels of 4.2 (interquartile range 3.7 to 4.8). Higher esRAGE was associated with lower BMI (p<0.001), lower eGFR (p=0.009), higher adiponectin (p<0.001) and white ethnicity (p<0.001). These relationships were similar to those for total sRAGE but these factors explained no more than 10% of the variance in either. esRAGE was an independent predictor of coronary heart disease events (HR=1.5 for a doubling of the esRAGE level, 95% CI: 1.1,2.0 p=0.009 adjusted for age, sex, eGFR, ethnicity, BMI, lipids and treatment allocation). This relationship was slightly weaker than the association of total sRAGE with CHD (p=0.001, difference in log likelihood=-2) and was not independent of total-esRAGE. In conclusion esRAGE is not more informative of vascular risk than total sRAGE and shares similar associations with other risk factors.-
dc.languageengen_HK
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/-
dc.relation.ispartofDiabetes-
dc.rightsThis is an author-created, uncopyedited electronic version of an article accepted for publication in TITLE [Journal URL] The American Diabetes Association (ADA), publisher of TITLE, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available online at [URL]-
dc.subjectMedical sciences-
dc.subjectEndocrinology-
dc.titleComparison of factors associated with total sRAGE and esRAGE in patients with type 2 diabetesen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailTan, KCB: kcbtan@hku.hken_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros174686en_HK
dc.identifier.volume59-
dc.identifier.issuesuppl.-
dc.publisher.placeUnited States-
dc.description.otherThe 70th Scientific Sessions of the American Diabetes Association (ADA), Orlando, FL., 25-29 June 2010. In Diabetes, 2010, v. 59 suppl., abstract no. 1108-P-

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